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Browsing by Author "Babatunde, A.S"

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Beta- Thalassaemia Trait Screening Using Capillary Electrophoresis Among Voluntary Blood Donor in North Central Nigeria
(College of Health Sciences, University of Ilorin, Ilorin, Nigeria., 2021-01) Durotoye, I A.; Salaudeen, AG; Sanni, E.O; Babatunde, A.S; Adekunle, D.K; Akande, T.M; Olawumi, H.O.; Musa, O.I
Beta-thalassaemia(â-thalassaemia) carriers exists in malaria endemic zones of sub-Sahara Africa including Nigeria. Studies on â-thalassaemia in Nigeria are few in the literature. The high variation in the prevalence of â-thalassaemia in Nigeria as reported in previous studies raises concern. Newer screening techniques such as capillary electrophoresis is now being used in clinical laboratories. This study screened for â-Thalassaemia carriers among voluntary blood donors using capillary electrophoresis. A descriptive cross-sectional study was conducted among 100 voluntary blood donors among students of Kwara State Polytechnic, Ilorin, Nigeria with age range of 18-34years. The participants consist of 55 males (55%) and 45 females (45%). Capillary electrophoresis using the Minicap system was used for determining the Haemoglobin A2 and F quantification in alkaline buffer (PH 9.4). Data analysis was done using SPSS and p-value<0.05 was taken as the level of significance The mean age of the participants was 22.23 ± 3.3 SD years(mean age of males 23±3.3 and females 20±2.8) The mean HbA2 among the participants was 3.49± 0.9SD (Range 0.8-5.30%). The mean HbF was 1.43± 0.57SD (Range 0.80-2.50%). Three (3/100) of the subjects had both elevated HbA2 > 3.9% and HbF >1%, giving a prevalence of 3% for â thalassaemia >1%, giving a prevalence of 3% for â thalassaemia carriers among blood donors in this study. The prevalence of â thalassaemia carrier was 3% in our study and found among female folks. Data from this study will be useful in raising awareness and genetic counseling especially among female blood donors.
Clinico-Laboratory Features of Multiple Myeloma in Selected Patients at University of Ilorin Teaching Hospital, North Central Nigeria
(Library and Publications Committee, University of Ilorin, Nigeria, 2020-03) Babatunde, A.S; Omokanye, K.O; Ogunfemi, M.K; Owoeye, O.A; Sanni, E.O; Durotoye, I A.; Shittu, A.O.
Multiple myeloma is an haematological disorder characterized by clonal proliferation of bone marrow plasma cells with production of increased amounts of monoclonal immunoglobulins which are detectable in blood and/or urine. The aim of the study was to describe the clinical and laboratory characteristics as well as treatment outcome in multiple myeloma patients diagnosed and managed at the Haematology Department of the University of Ilorin Teaching Hospital (U.I.T.H), Ilorin, North Central Nigeria, between 1 st January 2008 and 31 st December 2018. The study materials included bone marrow registers from the department and case folders of all multiple myeloma patients diagnosed within the study period. Relevant data including socio-demographic characteristics of patients, clinical features at presentation and laboratory tests results were extracted, documented and analyzed. Diagnosis was made in all patients based on the presence of major and/or minor criteria as described by the International Myeloma Working Group guidelines. Fifty eight (58) patients were diagnosed with multiple myeloma comprising of 31 males and 27 females (M:F ratio = 1.15:1). The median age of patients was 62.6 years (range = 39 – 85 years), and the most common presenting features included back pains (86.2%), bone pains (69%), inability to walk (67.2%) and anaemia (67.2%). High erythrocyte sedimentation rate > 30mm/Hr was seen in all patients (100%), Immunoglobulin G (Ig G) was the commonest monoclonal immunoglobulin demonstrated on serum protein electrophoresis (82.8%), and “punched out” osteolytic bone lesion on X-rays was demonstrated in 79.3% of cases. In resource- limited settings such as ours, the diagnosis and monitoring of patients with multiple myeloma still rely on the clinical and laboratory features of the disease to a large extent, hence the need for haemato-oncologists and physicians to be conversant with these features.
Determination of Normal and Variant Hemoglobin using Capillary Electrophoresis among Voluntary Blood Donors in North Central Nigeria: Implications on Blood Transfusion Services
(Faculty of Medicine and Health Sciences, Omdurman Islamic University, Sudan, 2021-03-31) Durotoye, I A.; Salaudeen, AG; Sanni, E.O; Babatunde, A.S; Durowade, A.K; Olawumi, H.O.; Akande, T.M; Musa, O.I
Background: Voluntary non-remunerated blood donation is a strategy adopted by World Health Organization aimed at ensuring safety and adequacy of blood supply. Sub-Saharan Africa has a high prevalence of hemoglobin disorders and therefore needs to adopt stringent measures in donor selection to ensure safety for the recipient of blood transfusion. This study aimed to analyze normal and variant hemoglobin among voluntary blood donors. Methods: In this descriptive cross-sectional study, 100 prospective blood donors including 55 (55%) males and 45 (45%) females, aged 18–34 years were recruited. Capillary electrophoresis using the Minicap system was used for determining the hemoglobin variants in alkaline buffer (PH 9.4). Data analysis was done using SPSS version 20 and p-value < 0.05 was considered as the level of significance Results: The mean age of the participants was 22.23 ± 3.3 SD years. The proportion of participants with genotype AA was 67 (67%), those with AS were 17 (22 %), while those with AC were 11 (11 %). While Hb A ≥ 90% was noted in 67 (67%) blood donors, Hb S was seen in 22 (22%) and Hb A2 > 3.5% in 57 (57%). Hb F > 2% was observed in 3% of the studied participants Conclusion: Variant hemoglobin is common among blood donors and this should be taken into consideration whenever blood is being crossmatched for recipients of blood transfusion. Data from this study will be useful in raising awareness and genetic counseling.
Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria
(Makerere University School of Medicine. College of Health Sciences, Kampala, Uganda, 2018-09-03) Oladosu-olayiwola, OR; Olawumi, H.O.; Babatunde, A.S; Ijaiya, M; Durotoye, I A.; Biliaminu, A.S; Ibraheem, R.M.
Background: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study com- pares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results: The mean age of the respondents was 29.9±5.2 years. The median(25 th -75 th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000-1560.000ng/ml), 0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respec- tively which were significantly higher than the corresponding values in the controls of 520 (24.000-1030.000ng/ml), 0.05 (0.040-0.090ng/ml and 2.650 (2.125-3.400ng/ml) respectively, p<0.05 each. Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.
Haemostatic Parameters During Pregnancy In Ilorin, Nigeria
(College of Health Sciences (A WHO Collaborating Centre for Research and Manpower Development), University of Ilorin, 2012-07) Durotoye, I A.; Babatunde, A.S; Olawumi, H.O.; Olatunji, P.O; Adewuyi, J.O
The objective of this study was to document the effect of pregnancy on some haemostatic parameters (Prothrombin time [PT], activated partial thromboplastin time [APTT], fibrinogen concentration, euglobin clot lysis time [ELT], and platelet count) in different trimesters of pregnancy. One hundred and eighty women with non-complicated pregnancy within the age range of 17-40 years (mean± SD 27.1±3.9years) were recruited for the study and sixty non-pregnant, normotensive apparently healthy age-matched women were used as control. All haemostatic parameters evaluated were determined using standard techniques. Significant differences were observed between the haemostatic parameters studied and controls except for platelet count. Prothrombin time was significantly shorter (p<0.001) and fibrinogen significantly higher (p<0.001) as pregnancy advanced but, other parameters were not influenced by the gestational age. There was a significant difference between the fibrinogen level in older subject compared with subject of younger age group with a mean of 5.5g/l and 4.0g/l (p<0.05) respectively. There was no significant relationship in the haemostatic parameters with parity and educational level of all the subjects. In conclusion, the results of haemostatic screening tests in this study suggest some degree of activation in pregnant women.
The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria
(Hindawi Publishing Corporation, 2015) Sani, M.A.; Adewuyi, J.O.; Babatunde, A.S; Olawumi, H.O; Shittu, R.O.
Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in theworld. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic systemic organ damage. Recent studies have suggested that individuals with SCA especially from developing countries are more likely to be iron deficient rather than have iron overload. The study aims to determine the iron status of SCA patients in Ilorin, Nigeria. Methods. A cross-sectional study of 45 SCA patients in steady state and 45 non- SCA controls was undertaken. FBC, blood film, sFC, sTfR, and sTfR/log sFC index were done on all subjects. Results. The mean patients’ serum ferritin (589.33 ± 427.61 ng/mL) was significantly higher than the mean serum ferritin of the controls (184.53 ± 119.74 ng/mL).Themean serum transferrin receptor of the patients (4.24 ± 0.17 𝜇g/mL) was higher than that of the controls (3.96 ± 0.17 𝜇g/mL) (𝑝 = 0.290). The mean serum transferrin receptor (sTfR)/log serum ferritin index of the patients (1.65 ± 0.27 𝜇g/mL) was significantly lower than that of the control (1.82 ± 0.18 𝜇g/mL) (𝑝 = 0.031). Conclusion. Iron deficiency is uncommon in SCA patients and periodic monitoring of the haematological, biochemical, and clinical features for iron status in SCA patients is advised.
Knowledge And Perception Of Sickle Cell Disease Among Senior Secondary School Students In Ilorin Metropolis
(College of Health Sciences (A WHO Collaborating Centre for Research and Manpower Development), University of Ilorin, Nigeria., 2013-06) Durotoye, I A.; Salaudeen, AG; Babatunde, A.S; Bosah, E.C
Sickle cell disease (SCD) remains a major public health issueand inadequate knowledge of SCD and lack of centres for genetic counseling in this country probably contributed to the high prevalence. The aim of this study was to assess the level of knowledge and perception of Senior Secondary School students in Ilorin Metropolis toward SCD and to determine the proportion of the students that know their haemoglobin genotype. Descriptive cross-sectional study was undertaken among students. Multistage sampling technique was used to select 500 respondents from 10 senior secondary schools and a semi-structured, self- administered questionnaire was used as a research tool. Analysis was done using SPSS version 20 software package. The mean age of the respondents was there were more females (54.4%) than males (45.6%). About 79.5% of the respondents have heard about SCD, but only 26.6% of them have good knowledge of SCD and haemoglobin genotype. The attitude of students toward a sickler was poor as many (51.0%) will not accept sickler as a friend and majority (90.3%) will not be willing to marry SCD patient. Only 52.0% of the respondents knew their haemoglobin genotype before the study. Female students had better knowledge score (p-value = There is need for continuous awareness programmes on SCD especially among male students and concerted policy should be put in place by government that genotype testing be a compulsory part of pre-secondary school entrance requirements.
Normal CD4 Count Range among Healthy Nigerian Population in Ilorin
(2014) Afolabi, J.K.; Fadeyi, A; Desalu, O O.; Durotoye, I. A; Fawibe, A. E.; Adeboye, M.A.N; Olawumi, H.O; Babatunde, A.S; Ernest, S.K; Aderibigbe, S.A; Saadu, R; Salami, A.K; Aboyeji, A.P
Background: For the establishment and monitoring of the immune status, CD4 count is critical. Objectives: To determine the CD4 count range of apparently healthy Nigerians resident in Ilorin and compare with the national value. Methods: An automated blood analyzer was used to determine the full blood count and CD4 count. The percentage of CD4 count was derived by using other variables. Results: Of the 1205 participants, the reference CD4 count (percentage of CD4) range for adult was 400 to 1288 cells/mm3 (19%-48%) and for children was 582 to 3652 cells/mm3 (17%-50%). CD4 count and percentage of CD4 were significantly (P ¼ .001) higher in females than in males, and the CD4 count declined significantly with increasing age (r ¼ .174, P .0001). The percentage of CD4 count shows less variation with age (r ¼ .051, P ¼ .076). Adult residents of Ilorin had significantly lower absolute mean CD4 count (808 + 260) than that of the national reference values of 847.0 + 307.0 cells/mm3 (P ¼ .001). Conclusion: We therefore advocate the use of CD4 count range derived in this study is lower than that of the national reference values.
PAI-1 and tPA as markers of severity among pre-eclamptics in a tertiary institution in north central Nigeria
(College of Medicine, University of Ibadan, Nigeria., 2016) Oladosu-Olayiwola, OR; Olawumi, H.O.; Babatunde, A.S; Ijaiya, M; Durotoye, I A.; Biliaminu, AS; Ibraheem, RM; Ogunfemi, MK
Objectives: Endothelial dysfunction contributes to the pathogenesis of pre-eclampsia as well as increased production of some factors such as tissue plasminogen activator (tPA) and plasminogen activator inhibitor type-1 (PAI-1). These factors are said to be biomarkers of pre-eclampsia but their role in assessing the severity of pre-eclampsia is under- reported. Methodology: A cross-sectional study involving 85 subjects with pre-eclampsia. They were classified clinically as having mild or severe pre-eclampsia using ACOG classification. Blood and urine samples were collected for determining tPA, PAI-1, D-dimer and proteinuria in the two groups. Clinical and laboratory values were compared using the IBM ® SPSS 20.0 (2011) soft ware packages. Results: The mean age of the respondents was 29.9±5.2 years. Forty-five (52.9%) of the subjects had severe pre-eclampsia while 40(47.1%) had mild pre-eclampsia. The median values of tPA and PAI-1 of subjects with severe pre-eclampsia were significantly higher than the corresponding values in subjects with mild pre-eclampsia (each p=0.001). There was a positive correlation between each of the tPA and PAI-1 levels with the degree of severity of pre-eclampsia (p=0.001 each). Conclusion: Fibrinolytic proteins like tPA and PAI- 1 are useful in assessing the severity of pre- eclampsia.
Pattern of Childhood Malignancies in Ilorin, Nigeria: Challenges and Strategies for Management in a Tertiary Health Institution
(Official Journal of IbnSina Medical Colleg, 2015-07-03) Babatunde, A.S; Gobir, A.A.; Adebayo, MAN; Adebayo-Oloko, A.; Durotoye, I A.
Objective: The study was carried out to document the pattern of childhood malignant tumors which were diagnosed at the University of Ilorin Teaching Hospital, Ilorin, and compare with previous reports from other parts of Nigeria and elsewhere and also highlight the challenges and strategies for effective management of these diseases in our environment. Methods: A ten year retrospective analysis of all cancers diagnosed in children below the age of 18 years at the study centre between January 2000 and December 2009 was carried out. Case folders of all children diagnosed with malignant tumors within the study period were retrieved from the Cancer Registry Department of the Hospital and were analyzed with respect to age, gender, morphological or histological type of malignancy, extent of disease, treatment modality, and survival outcome. Results: Ninety nine (99) children were diagnosed with various malignancies during the study period. Sixty seven (67; 67.7%) were boys and 32 (32.3%) were girls giving a male to female ratio of 2:1. There were 22 cases (22.2%) recorded in children aged below 4 years and 72 cases (72.7%) were diagnosed in children between 4 -14 years. Lymphomas were the most prevalent malignancies encountered accounting for 54 cases (54.5%), Burkitt’s lymphoma constituted 43 (79.6%) of all lymphoma cases. The distribution of the five foremost malignancies recorded were as follows: Burkitt’s lymphoma (43 cases), Nephroblastoma (10 cases), Retinoblastoma (8 cases), Non Hodgkin’s lymphoma (7 cases) and Acute leukaemias (5 cases). Other malignancies included Osteogenic sarcoma (5), Hodgkin’s lymphoma (4), and 2 cases each of primary liver cell carcinoma, neuroblastoma, rhabdomyosarcoma and nasopharyngeal tumor. Conclusion: The distribution of the various childhood malignant tumors recorded in this study is similar to the pattern reported in previous studies from Nigeria and other countries. However, there appears to be a lower prevalence of leukemia recorded in this study compared to the earlier findings. The challenges which were identified in the diagnosis, management and overall outcome of our patients included limited number of diagnostic tools, late presentation in the hospital, high patient default rate, poverty, and shortage of chemotherapeutic drugs.
PATTERN OF NEUROLOGICAL COMPLICATIONS OF CHRONIC MYELOID LEUKAEMIA IN ILORIN, NIGERIA: A TEN YEAR REVIEW
(Faculty of Clinical Science, Ambrose Alli University, Ekpoma, Nigeria., 2018) Babatunde, A.S; Olawumi, H.O.; Durotoye, I A.; Shittu, E.O; Oyeleke, S.A
Aim and Objective: The study was carried out to document the pattern of neurological complications seen in patients with chronic myeloid leukemia who were managed at the University of Ilorin Teaching Hospital, Ilorin and compare with previous reports from other parts of Nigeria and elsewhere. Materials and Methods: A ten year retrospective analysis of all cases of CML managed at the study centre between January 2006 and December 2015 was carried out. Case folders of all patients diagnosed with CML during the study period, and the Malignancy registers of the Haematology department were retrieved and analyzed. Relevant information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. Results: Thirty six (36) patients were diagnosed with CML during the study period. There were 21 (58.3%) males and 15 (41.7%) females, giving a male: female ratio of 1.4:1.The mean age of the patients at diagnosis was 37.5 years (range, 11-75 years). Nine (25%) patients presented with various forms of neurological complications and the mean WBC count in them was 383.2 x 109/L (280.5 601.0 x 109/L). Auditory complications were the commonest neurological deficits found in 6(66.7%) of the 9 patients with neurological manifestations. Conclusion: The neurological complications recorded in this study were similar to those reported in previous studies from Nigeria and other countries. These complications need to be looked for at presentation and adequately characterized as their presence could significantly influence the prognosis of the disease and decisions on management modalities.
REFERENCE VALUES OF HAEMATOLOGICAL PARAMETERS OF HEALTHY ADULTS IN THE NORTH CENTRAL ZONE OF NIGERIA
(Kenya Medical Association, 2015-08) Olawumi, H.O.; Durotoye, I A.; Afolabi, J.K; Desalu, O.O; Aderibigbe, S.A; Babatunde, A.S; Ernest, S.K; Fawibe, A.E; Salami, A.K; Saadu, R; Adeboye, MAN; Aboyeji, A.P
Background: Haematological parameters differ from one population to another due to several factors. To determine the clinical implication of the blood parameters of an individual in the state of health or disease, we need to have the knowledge of the normal reference range for that locality. Objectives: To determine the reference values of haematological parameters of apparently healthy adults in Ilorin. Design: A descriptive cross sectional study. Setting: Ilorin, North Central zone of Nigeria Subjects: Nine hundred and ten (443 males and 467 females) randomly selected normal, HIV negative individuals aged 18-65 years Results: The red blood cell count, Haemoglobin concentration, PCV and MCHC were significantly higher among males than females while the platelet count, total WBC count and absolute neutrophil count were significantly higher in females than in males. There was however no significant gender difference in the values of MCV, MCH and absolute lymphocyte count. The normal reference values obtained in this study were notably different from those that are used currently in the hospital. Conclusion: The normal reference value obtained in this study was notable different from those that are currently used in the hospital. These findings will have clinical implications regarding the adjustment of our current reference values and definitely add value to the management of patients in this part of the country.

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