PAI-1 and tPA as markers of severity among pre-eclamptics in a tertiary institution in north central Nigeria
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
College of Medicine, University of Ibadan, Nigeria.
Abstract
Objectives: Endothelial dysfunction contributes to
the pathogenesis of pre-eclampsia as well as
increased production of some factors such as tissue
plasminogen activator (tPA) and plasminogen
activator inhibitor type-1 (PAI-1). These factors are
said to be biomarkers of pre-eclampsia but their role
in assessing the severity of pre-eclampsia is under-
reported.
Methodology: A cross-sectional study involving 85
subjects with pre-eclampsia. They were classified
clinically as having mild or severe pre-eclampsia
using ACOG classification. Blood and urine samples
were collected for determining tPA, PAI-1, D-dimer
and proteinuria in the two groups. Clinical and
laboratory values were compared using the
IBM ® SPSS 20.0 (2011) soft ware packages.
Results: The mean age of the respondents was
29.9±5.2 years. Forty-five (52.9%) of the subjects
had severe pre-eclampsia while 40(47.1%) had mild
pre-eclampsia. The median values of tPA and PAI-1
of subjects with severe pre-eclampsia were
significantly higher than the corresponding values
in subjects with mild pre-eclampsia (each p=0.001).
There was a positive correlation between each of
the tPA and PAI-1 levels with the degree of severity
of pre-eclampsia (p=0.001 each).
Conclusion: Fibrinolytic proteins like tPA and PAI-
1 are useful in assessing the severity of pre-
eclampsia.
Description
Keywords
Severe pre-eclampsia; fibrinolytic proteins, D-dimer, PAI-1,tPA.
Citation
Oladosu O. R., Olawumi H.O., Babatunde A.S., Ijiaya M., Durotoye I. A., Biliaminu A.S., Ibraheem M, Ogunfemi M.K.