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SYNTHESIS, CHARACTERIZATION, X-RAY CRYSTALLOGRAPHIC ANALYSIS AND BIOLOGICAL ACTIVITY OF SOME 3D BLOCK METAL IONS- QUINOLINYL IMIDAZOLE COMPLEXES
(University of Ilorin, 2025) BUSARI Hassan Kehinde
The increasing prevalence of antimicrobial resistance and chronic inflammatory diseases poses a substantial concern in contemporary medicine. Numerous existing medications exhibit restricted efficacy; hence it becomes imperative to discover new drugs to combat this problem. This research aimed at synthesizing, characterizing, and evaluating antimicrobial and anti-inflammatory activities of mixed ligand metal complexes of quinoline carboxylic acids and imidazole derivatives. Transition metals, when reacted with drugs can improve the efficacy of the emerging drug. The objectives of this study were to: (i) synthesize mixed ligand metal complexes of quinoline carboxylic acids with selected imidazole ligands; (ii) characterize the complexes using standard analytical and spectroscopic techniques; (iii) determine the antimicrobial activity of the metal complexes; and (iv) investigate the anti-inflammatory activity of the complexes. The complexes were synthesized by mixing selected metal salt solution with solution of the ligand(s) and stirred at 40 oC or 50 oC to yield the corresponding compounds. The compounds were structurally characterized using Elemental analysis (CHN), Fourier Transform Infrared (FTIR) spectroscopy, Ultra-Violet visible (UV-Vis) spectroscopy, Thermogravimetric analysis (TGA) and Single crystal X-ray diffraction technique (SCXRD). The in-vitro antimicrobial efficacies of the metal complexes against four bacterial and three fungal isolates were evaluated using broth dilution method and p-iodonitrotetrazolium (INT) assays. The in-vitro anti-inflammatory activities were evaluated using protein denaturation assay. The findings of the study were that: i.seventeen (17) complexes were synthesized and formulated as: [Zn(q2c)2(mim)2] (1); [Cu(q2c)2(mim)2] (2); [Cu(q2c)2(mim)] (3); [Co(q2c)2(mim)2] (4); [Ni(q2c)2(mim)2] (5); [Zn(q2c)2(mim)] (6); [Zn(q2c)2(bim)2] (7); [Cu(q2c)2(bim)2] (8); [Co(q2c)2(bim)2] (9); [Ni(q2c)2(bim)2] (10); [Cu(q2c)2(pim)2] (11); [Zn(q2c)2(pim)2] (12); [Co(q2c)2(pim)2] (13); [Ni(q2c)2(pim)2] (14); [Cu(q4c)4(bim)2] (15); [Zn(q4c)4(bim)2] (16); [Cu(q4c)4(mim)2] (17). Compound 4, 6, and 7 were obtained as single crystals; ii.the spectroscopic and X-ray crystallographic techniques revealed that the coordination modes of the metal ions to the ligands were either monodentate or bidentate with different geometries. SCXRD study revealed complex 4 to have crystallized in the system, space group , while 6 and 7 crystallized in the monoclinic system, space group P21/n. The SCXRD also confirmed square pyramidal structure for 4 and octahedral geometry for 6 and 7; iii.the synthesized compounds exhibited remarkable in vitro antimicrobial activity. All the microorganisms tested were susceptible to the synthesised compounds with S. pyogens the most susceptible with MIC value of 7.9-15.7 µg/mL; and iv.the result of the anti-inflammatory activity showed that compounds 2, 5, 10, 15 and 16 have higher activity than the standard drug, diclofenac, as obtained from their IC50 values. The study concluded that the complexes exhibited antimicrobial and anti-inflammatory activities compared to the ligands. The study, therefore, recommended that compounds 2, 5, 10, 15 and 16 can serve as good anti-inflammatory agents.compounds 2, 5, 10, 15 and 16 can serve as good anti-inflammatory agents.
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Globalising Education: Strategies, Challenges, and Sustainability
(Centre for Internationalisation and Strategic Partnership (CISP), University of Ilorin, Nigeria, 2026-07) OLADIPO Francisca Onaolapo; ARULOGUN Tayo; AIMAS-LOVE Lily
This study addressed global disparities in AI education through curriculum internationalisation. Analysing AI educational frameworks across 12 countries on six continents, we identified key barriers: algorithmic colonialism, culturally homogeneous training data, English-language dominance, and context-insensitive pedagogies. The study proposed the Culturally Responsive AI Education (CRAE) framework featuring three dimensions: pluralistic epistemological foundations integrating diverse knowledge traditions, localised dataset development, reflecting regional priorities, and multilingual programming environments, reducing linguistic barriers. Our 30-month mixed-methods study examined curriculum documents from 38 institutions, conducted 54 faculty interviews, and analysed instructional materials, using comparative methods. Implementation across universities in Nigeria, Brazil, India, and Germany showed enhanced student engagement and technical mastery through connecting AI concepts to locally meaningful problems. Results indicated that the CRAE framework facilitates genuine knowledge exchange between Western and Global South institutions and has the potential to reshape the global AI development landscape to address diverse regional priorities. This research contributed to advancing educational practices that can help democratise AI innovation while preparing students to work effectively across cultural boundaries in an increasingly interconnected technological landscape. By fundamentally reconsidering how AI is taught and applied across diverse cultural contexts, this study contributed to a more equitable distribution of AI benefits globally. Keywords: Internationalization, Curriculum, Artificial Intelligence Education, Cross-cultural Education.
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Assessing the Use of Multimedia Technology in Enhancing Learning Outcomes for Students with Special Educational Needs
(Centre for Internationalisation and Strategic Partnership (CISP), University of Ilorin, Nigeria, 2026-07) ABEGUNDE, Ifeoluwa Tunrayo,; FALOPE Blessing Gbemishola; IBRAHIM Adebowale Ibukun
Abstract This study focused on the incorporation of multimedia in special needs education, with Kwara State’s School of Special Needs in view. The objectives of the study were to examine the extent of the incorporation, perceived benefits and challenges of the use of multimedia technology in special needs education. Piaget's theory of cognitive development underlined the research work. Semi-structured interview questions were administered to the participants of this study, using a snowball sampling approach, and their responses were analysed thematically. The results showed a high level of multimedia incorporation in special needs education in the case study of this research. However, there are several impediments to its adoption. The study recommended that training and re-training for educators must be prioritised; infrastructure must be improved; and policies should be reviewed to enable a guided use of mobile learning devices and locally multimedia contents. Keywords: Multimedia, Education, Special needs, Piaget’s theory of cognitive development.
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LEVERAGING THE EXPERTISE OF CHEMISTS IN ENVIRONMENTAL MANAGEMENT: A FOCUS ON ANALYTICAL, ENVIRONMENTAL, AND MATERIAL FIELDS
(The Library and Publications Committee, University of Ilorin, Ilorin, Nigeria, 2025-11-06) PROFESSOR HUSSEIN KEHINDE OKORO
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CARE, COMPASSION AND CAPABILITY: THE TRIFECTA OF NURSING EXCELLENCE
(The Library and Publications Committee, University of Ilorin, Ilorin, Nigeria, 2026-04-09) PROFESSOR SIMEON KAYODE OLUBIYI