Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria
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Date
2018-09-03
Journal Title
Journal ISSN
Volume Title
Publisher
Makerere University School of Medicine. College of Health Sciences, Kampala, Uganda
Abstract
Background: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation
with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study com-
pares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women.
Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and
eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1,
D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method
on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level
of significance was a p-value <0.05.
Results: The mean age of the respondents was 29.9±5.2 years. The median(25 th -75 th percentile) values of D-dimer, tPA,
and PAI-1 of subjects were 730 (305.000-1560.000ng/ml), 0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respec-
tively which were significantly higher than the corresponding values in the controls of 520 (24.000-1030.000ng/ml), 0.05
(0.040-0.090ng/ml and 2.650 (2.125-3.400ng/ml) respectively, p<0.05 each.
Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty
state in pre-eclampsia thus, measuring their levels can help in the management of the condition.
Description
Keywords
Fibrinolysis, pregnancy ,pre-eclampsia.
Citation
Oladosu-Olayiwola O., Olawumi. H., Babatunde. A., Ijiaya M., Durotoye I., Biliaminu S., Ibraheem R