The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria
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Date
2015
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Publisher
Hindawi Publishing Corporation
Abstract
Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in theworld. It is characterized by anaemia, periodic
attacks of thrombotic pain, and chronic systemic organ damage. Recent studies have suggested that individuals with SCA especially
from developing countries are more likely to be iron deficient rather than have iron overload. The study aims to determine the
iron status of SCA patients in Ilorin, Nigeria. Methods. A cross-sectional study of 45 SCA patients in steady state and 45 non-
SCA controls was undertaken. FBC, blood film, sFC, sTfR, and sTfR/log sFC index were done on all subjects. Results. The mean
patients’ serum ferritin (589.33 ± 427.61 ng/mL) was significantly higher than the mean serum ferritin of the controls (184.53 ±
119.74 ng/mL).Themean serum transferrin receptor of the patients (4.24 ± 0.17 𝜇g/mL) was higher than that of the controls (3.96 ±
0.17 𝜇g/mL) (𝑝 = 0.290). The mean serum transferrin receptor (sTfR)/log serum ferritin index of the patients (1.65 ± 0.27 𝜇g/mL)
was significantly lower than that of the control (1.82 ± 0.18 𝜇g/mL) (𝑝 = 0.031). Conclusion. Iron deficiency is uncommon in SCA
patients and periodic monitoring of the haematological, biochemical, and clinical features for iron status in SCA patients is advised.
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Keywords
Sickle Cell Anaemia, Patients, North Central Nigeria, Ilorin
Citation
Sani, M.A., Adewuyi, J.O., Babatunde, A.S., Olawumi, H.O., & Shittu, R.O. (2015). The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria. Advances in Hematology. 2015, Article ID 386451, 5 pages