Browsing by Author "Babamale, Halimah Funmilayo"

Now showing 1 - 10 of 10
  • Item
    Artemether-Lumefantrine Mixed Ligand Complexes: Synthesis and in vitro AntiplasmodialActivity Studies
    (Al-Hikmah University, 2018-12-05) Rajee, Abdullahi O; Babamale, Halimah Funmilayo; Lawal, Misitura; Ayinla, S O; Lawal, Amudalat; Obaleye, Joshua A
    Malaria is one of the main causes of mortality and morbidity in the world, endangering billions and affecting millions of people each year. Resistance to common antimalarial drugs has proven to be a challenging problem in malaria control. In an attempt to develop efficacious compounds against sensitive and multidrug resistant falciparum malaria, four new complexes of mixed ligands (artemether and lumefantrine) were synthesized using template method. Their antiplasmodial activity potential was evaluated and compared with chloroquine and the parent ligands. The compounds were active against the tested parasite strains. The presence of the metal ions significantly improved the antiplasmodial action against the drug-resistant parasite strains when compared to chloroquine. Additionally, their biological activity was assessed using several in vitro assays. Biological and physical properties were correlated to the antimalarial activity.
  • Item
    Chelation, Characterization and Antimicrobial Screening of Some Mixed Antituberculosis–Vitamin Metal Drug Complexes
    (Al-Hikmah University, 2017-05-04) Bamigboye, Mercy O; Obaleye, Joshua A; Lawal, Amudat; Babamale, Halimah Funmilayo; Ajibola, A. A; Adimula, Vincent O; Lawal, Mistura
    In this study, mixed Zn(II), Cu(II), Co(II) complexes of Isoniazid and vitamin C were synthesized and characterized by melting point, conductivity measurement, Fourier Transform Infra-red (FT-IR), Atomic Absorption Spectroscopy and elemental analyses. The bonding nature of the mixed parent ligands and the structure of the complexes were based on analytical and spectroscopic techniques. The complexes were proposed to have the formula [M1L1L2(Cl2)], [M2L1L2(SO4)], [M3L1L2(Cl2)] where M1 = Zn(II), M2 = Cu(II), M3= Co (II) L1= Isoniazid and L2 = Vitamin C. The infra-red data relate to the results of the most informative and indicative region. The result of spectra data confirmed that the two ligands were bidentate in their mode of coordination with the metal ions. The complexes are in octahedral geometry and the molar conductance was found to be non-electrolytic in nature. Antimicrobial test was carried out against four bacterial species namely Bacillus subtilus, Staphylococuss aureus, Escherichia coli and Pseudomonas aeroginosa. All the complexes showed higher antibacterial activity at the same concentration against the microorganisms used compared to the ligands.
  • Item
    Development and Evaluation of Land Use Planning Framework Based on Major Accident Hazard Facility
    (2019) Qaeem, M; Rashid, Z.A; Babamale, Halimah Funmilayo; Busari, Yusuf Olanrewaju; Alizada, Amir M
    The identification of more hazard facilities with respect to land use planning (LUP) to solve the adverse consequences that threatens nature and human life. There is an urgent need for better understanding of the current regulations and frameworks of major hazard facility (MHF) siting in order to adapt a strategic approach for LUP and preventing major accident hazards. This research aims to develop a checklist/framework to study LUP- MHF and validate its effectiveness with practical use in LPG’s site planning. The results of applying this checklist in five LPG siting facilities in Malaysia which stored more than 50 tons in their premises and comparison with various standard of consequence-based method (CBM) applied from several countries show that most of the receptor below 100 m will be exposed to high lethality. However, degree of lethality is reduced when the distance of the receptor is increased. Based on results, French method is more stringent compared to Italy and Malaysia. According to findings from library – based research and practical use of developed checklist/framework in MHF-LUP, the Malaysia method is similar to UK standards that should be revised because there is increasing of 6.67% of the people around the LPG vicinity that could be mentioned as unsafe. The research suggested that to impose additional criteria in between 4 - 12.5 kW/m2 as practiced currently in Malaysia. The iterative cycles of evaluation and assessing the consequences of a number of scenarios, which then serve as a reference for the determination of protection zones around the installation is also suggested to avoid Domino-Effect
  • Item
    The First tetrafluorinated azobenzene-imidazolium ionic conjugates as potential thermotropic liquid crystalline drugs: Self-assembly properties and cytotoxic effects
    (Elsevier, 2022-01-21) Babamale, Halimah Funmilayo; Khor, Boon-Keat; Chear, Nelson Jeng-yeou; Haque, Rosenani A; Yam, WanSinn
    A new series of tetrafluorinated azobenzene-imidazolium ionic liquid crystals (ILCs) of varying alkyl chain length (n = 10–18 in even parity) in the imidazolium cationic head group was prepared and characterized using FTIR and NMR spectroscopy, and elemental microanalysis. Their thermal and phase properties were investigated using differential scanning calorimetry (DSC) and polarized optical microscope (POM). Their phase properties and morphology were influenced by fluorination and alkyl chain length. Long alkyl chains were necessary to induce liquid crystalline behaviour in these salts. All homologues were mesogenic, exhibiting stable smectic A phase with broad temperature range. Cytotoxic effects of these ILCs against human cervical cancer (HeLa) cells and normal fibroblasts was evaluated using the MTT assay. Cytotoxicity of these ILCs was dependent on the alkyl chain length in the imidazolium cationic head. All the salts were less toxic towards normal fibroblasts and exhibited 7–27-fold enhancement in cytotoxicity against HeLa cells (24hr IC50 ranged between 0.61 μM -2.84 μM) as compared to the standard therapeutic drug, Etoposide (IC50 = 25.67 μM). Long homologues (n = 16, 18) were selective towards cancer cells with selectivity index ≥ 3. These thermotropic ILCs could be doped with room-temperature mesomorphous polymers for the formulation of safe and selective anticancer drugs
  • Item
    Mixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studies
    (Library and Publications Committee, University of Ilorin, Ilorin, Nigeria., 2019) Babamale, Halimah Funmilayo; Rajee, Abdullahi Ola; Obaleye, Joshua Ayoola; Lawal, Amudat; Bamigboye, Mercy Obaleye; Lawal, Misitura; Sa'ad, H.O.
    Some transition metal complexes of mixed artemether, ascorbic acid and lumefantrine have been synthesized and characterized using UV/Vis, FTIR, Atomic Absorption Spectroscopy (AAS) and Gas chromatography-Mass Spectroscopy (GC-MS). The results revealed that the artemether and ascorbic acid are chelating ligands and coordinates through the oxygen of the carbonyl groups while lumefantrine coordinates through the hydroxyl group in a monodentate fashion. The metal complexes were investigated for biological activity using five bacterial species - Staphylococcus aureus, Escherichia coli, Bacillus aureus and Pseudomonas aeruginosa. It was observed that the synthesized complexes were more effective towards the five bacteria species than the free drugs.
  • Item
    Mixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studies
    (Faculty of Physical Sciences, University of Ilorin, 2019) Babamale, Halimah Funmilayo; Obaleye, Joshua A; Lawal, Amudalat; Rajee, Abdullahi O; Bamigboye, Mercy O; Lawal, Misitura; Sa'ad, H. O
    Some transition metal complexes of mixed artemether, ascorbic acid and lumefantrine have been synthesized and characterized using UV/Vis, FTIR, Atomic Absorption Spectroscopy (AAS) and Gas chromatography-Mass Spectroscopy (GCMS). The results revealed that the artemether and ascorbic acid are chelating ligands and coordinates through the oxygen of the carbonyl groups while lumefantrine coordinates through the hydroxyl group in a monodentate fashion. The metal complexes were investigated for biological activity using five bacterial species - Staphylococcus aureus, Escherichia coli, Bacillus aureus and Pseudomonas aeruginosa. It was observed that the synthesized complexes were more effective towards the five bacteria species than the free drugs.
  • Item
    NANOCELLULOSE AS A STABILIZING AGENT IN THE SYNTHESIS OF SILVER NANOPARTICLES UNDER TRACE LEVEL TRISODIUM CITRATE
    (Faculty of Pure and Applied Sciences, LAUTECH, Ogbomoso, 2022) Babamale, Halimah Funmilayo; Saliu, Oluwaseyi D; Rajee, Abdullah O; Kuranga, Ibrahim Ayinla; Faluyi, Ayodele S
    Silver nanoparticles (AgNPs) synthesized in dilute solutions of silver metal precursor and reducing agents are less toxic and safe for diverse applications.In this research, AgNPs which were successfully synthesized at trace level of trisodium citrate and stabilized with cellulose nanoparticles were characterized withFTIR spectroscopy,UV-Vis, x-raydiffraction (XRD) and scanning electron microscopy (SEM).The AgNPs synthesized in the presence of nanocellulose had better surface plasmon resonance and showed lesser aggregation according to the UV and SEM results.
  • Item
    NANOCELLULOSE AS A STABILIZING AGENT IN THE SYNTHESIS OF SILVER NANOPARTICLES UNDER TRACE LEVEL TRISODIUM CITRATE
    (Faculty of Pure and Applied Science, Ladoke Akintola University of Technology. Ogbomoso, Oyo State. Nigeria., 2022) Babamale, Halimah Funmilayo; SALIU, OLUWASEYI DAMILARE; RAJEE, ABDULLAH OLA; KURANGA, IBRAHIM AYINLA; FALUYI, AYODELE SAMUEL
    Silver nanoparticles (AgNPs) synthesized in dilute solutions of silver metal precursor and reducing agents are less toxic and safe for diverse applications.In this research, AgNPs which were successfully synthesized at trace level of trisodium citrate and stabilized with cellulose nanoparticles were characterized withFTIR spectroscopy,UV-Vis, x-raydiffraction (XRD) and scanning electron microscopy (SEM).The AgNPs synthesized in the presence of nanocellulose had better surface plasmon resonance and showed lesser aggregation according to the UV and SEM results.
  • Item
    Stability constant of some Anti-Tuberculosis metal drug complexes
    (University of Ilorin, 2017) Bamigboye, Mercy O; Eke, U B; Obaleye, Joshua A; Babamale, Halimah Funmilayo
    The formation of Isonicotinic Acid Hydrazide and Pyrazine-2-carboxamide complexes were prepared and analyzed by determining the stoichiometry and stability constant (Spectrophotometric method). The ionic strength used was maintained constant at 0.1 M KNO3. The stability constants were calculated to be log 61.21 - 254 in Isonicotinic Acid Hydrazide while in Pyrazine-2-carboxamide 55.5 - 274.29. The order of stability constant of the metal to ligand reaction follows this trend: Ni(II) > Cu(II) > Co(II) > Fe(II) > Mn(II) > Zn(II). The order of the stability constant is in agreement with the trend of Electronegativity.
  • Item
    SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MIXED ASCORBIC ACID - NICOTINAMIDE METAL COMPLEXES
    (Bayero University Kano, 2015) Lawal, Amudalat; Amolegbe, S A; Rajee, Abdullahi O; Babamale, Halimah Funmilayo; Yunus-Issa, M T
    The present study aimed at synthesizing copper(II) and zinc(II) complexes of mixed ascorbic acid and nicotinamide and physiochemically characterize by solubility test, melting point, conductivity test, infrared, electronic and proton nuclear magnetic resonance techniques. The result of the physiochemical studies indicated 1:1 stoichiometry and were supported by the spectroscopic data. The antimicrobial activities of the mixed complexes were carried out against Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Penicillum, spp Aspergillus flavus and Aspergillus niger. The result of the infrared data showed that ascorbic acid coordinates through the oxygen of the carbonyl group and that of enolic C-2 hydroxyl group, while nicotinamide coordinates through the nitrogen atom of the pyridine ring. The result of the antimicrobial studies showed that the mixed complexes have higher inhibitory activity than the original ligands against the tested bacteria and fungi species.