Mixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studies

No Thumbnail Available

Date

2019

Journal Title

Journal ISSN

Volume Title

Publisher

Library and Publications Committee, University of Ilorin, Ilorin, Nigeria.

Abstract

Some transition metal complexes of mixed artemether, ascorbic acid and lumefantrine have been synthesized and characterized using UV/Vis, FTIR, Atomic Absorption Spectroscopy (AAS) and Gas chromatography-Mass Spectroscopy (GC-MS). The results revealed that the artemether and ascorbic acid are chelating ligands and coordinates through the oxygen of the carbonyl groups while lumefantrine coordinates through the hydroxyl group in a monodentate fashion. The metal complexes were investigated for biological activity using five bacterial species - Staphylococcus aureus, Escherichia coli, Bacillus aureus and Pseudomonas aeruginosa. It was observed that the synthesized complexes were more effective towards the five bacteria species than the free drugs.

Description

Keywords

Artemether, lumefantrine, ascorbic acid, metal complexes, biological activity.

Citation

Babamale, H.F., Obaleye, J.A., Lawal, A., Rajee, A.O., Bamigboye, M.O., Lawal, M. & Sa’ad, H.O. (2019) Mixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studies. Centrepoint Journal (Science Edition). 25(2): 21-32.

Collections