Mixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studies

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dc.contributor.authorBabamale, Halimah Funmilayo
dc.contributor.authorRajee, Abdullahi Ola
dc.contributor.authorObaleye, Joshua Ayoola
dc.contributor.authorLawal, Amudat
dc.contributor.authorBamigboye, Mercy Obaleye
dc.contributor.authorLawal, Misitura
dc.contributor.authorSa'ad, H.O.
dc.date.accessioned2023-05-09T17:26:14Z
dc.date.available2023-05-09T17:26:14Z
dc.date.issued2019
dc.description.abstractSome transition metal complexes of mixed artemether, ascorbic acid and lumefantrine have been synthesized and characterized using UV/Vis, FTIR, Atomic Absorption Spectroscopy (AAS) and Gas chromatography-Mass Spectroscopy (GC-MS). The results revealed that the artemether and ascorbic acid are chelating ligands and coordinates through the oxygen of the carbonyl groups while lumefantrine coordinates through the hydroxyl group in a monodentate fashion. The metal complexes were investigated for biological activity using five bacterial species - Staphylococcus aureus, Escherichia coli, Bacillus aureus and Pseudomonas aeruginosa. It was observed that the synthesized complexes were more effective towards the five bacteria species than the free drugs.en_US
dc.identifier.citationBabamale, H.F., Obaleye, J.A., Lawal, A., Rajee, A.O., Bamigboye, M.O., Lawal, M. & Sa’ad, H.O. (2019) Mixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studies. Centrepoint Journal (Science Edition). 25(2): 21-32.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/9949
dc.language.isoenen_US
dc.publisherLibrary and Publications Committee, University of Ilorin, Ilorin, Nigeria.en_US
dc.relation.ispartofseries22(2);21-32
dc.subjectArtemether, lumefantrine, ascorbic acid, metal complexes, biological activity.en_US
dc.titleMixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studiesen_US
dc.typeArticleen_US

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