Stability constant of some Anti-Tuberculosis metal drug complexes
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Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
University of Ilorin
Abstract
The formation of Isonicotinic Acid Hydrazide and Pyrazine-2-carboxamide complexes were prepared and
analyzed by determining the stoichiometry and stability constant (Spectrophotometric method). The ionic
strength used was maintained constant at 0.1 M KNO3. The stability constants were calculated to be log 61.21 -
254 in Isonicotinic Acid Hydrazide while in Pyrazine-2-carboxamide 55.5 - 274.29. The order of stability
constant of the metal to ligand reaction follows this trend: Ni(II) > Cu(II) > Co(II) > Fe(II) > Mn(II) > Zn(II).
The order of the stability constant is in agreement with the trend of Electronegativity.
Description
Keywords
Isonicotinic Acid Hydrazide, Pyrazine-2-carboxamide, Complexes, Ionic strength, Stability constant