SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MIXED ASCORBIC ACID - NICOTINAMIDE METAL COMPLEXES
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Date
2015
Journal Title
Journal ISSN
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Publisher
Bayero University Kano
Abstract
The present study aimed at synthesizing copper(II) and zinc(II) complexes of mixed ascorbic acid
and nicotinamide and physiochemically characterize by solubility test, melting point, conductivity
test, infrared, electronic and proton nuclear magnetic resonance techniques. The result of the
physiochemical studies indicated 1:1 stoichiometry and were supported by the spectroscopic data.
The antimicrobial activities of the mixed complexes were carried out against Bacillus subtilis,
Escherichia coli, Staphylococcus aureus, Penicillum, spp Aspergillus flavus and Aspergillus niger.
The result of the infrared data showed that ascorbic acid coordinates through the oxygen of the
carbonyl group and that of enolic C-2 hydroxyl group, while nicotinamide coordinates through the
nitrogen atom of the pyridine ring. The result of the antimicrobial studies showed that the mixed
complexes have higher inhibitory activity than the
original ligands against the tested bacteria and fungi species.
Description
Keywords
Ascorbic acid, Nicotinamide, Synthesis, Antimicrobial, Complexes