SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MIXED ASCORBIC ACID - NICOTINAMIDE METAL COMPLEXES

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dc.contributor.authorLawal, Amudalat
dc.contributor.authorAmolegbe, S A
dc.contributor.authorRajee, Abdullahi O
dc.contributor.authorBabamale, Halimah Funmilayo
dc.contributor.authorYunus-Issa, M T
dc.date.accessioned2023-08-24T10:26:02Z
dc.date.available2023-08-24T10:26:02Z
dc.date.issued2015
dc.description.abstractThe present study aimed at synthesizing copper(II) and zinc(II) complexes of mixed ascorbic acid and nicotinamide and physiochemically characterize by solubility test, melting point, conductivity test, infrared, electronic and proton nuclear magnetic resonance techniques. The result of the physiochemical studies indicated 1:1 stoichiometry and were supported by the spectroscopic data. The antimicrobial activities of the mixed complexes were carried out against Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Penicillum, spp Aspergillus flavus and Aspergillus niger. The result of the infrared data showed that ascorbic acid coordinates through the oxygen of the carbonyl group and that of enolic C-2 hydroxyl group, while nicotinamide coordinates through the nitrogen atom of the pyridine ring. The result of the antimicrobial studies showed that the mixed complexes have higher inhibitory activity than the original ligands against the tested bacteria and fungi species.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/11676
dc.language.isoenen_US
dc.publisherBayero University Kanoen_US
dc.subjectAscorbic aciden_US
dc.subjectNicotinamideen_US
dc.subjectSynthesisen_US
dc.subjectAntimicrobialen_US
dc.subjectComplexesen_US
dc.titleSYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MIXED ASCORBIC ACID - NICOTINAMIDE METAL COMPLEXESen_US
dc.typeArticleen_US

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