Artemether-Lumefantrine Mixed Ligand Complexes: Synthesis and in vitro AntiplasmodialActivity Studies
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Date
2018-12-05
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Publisher
Al-Hikmah University
Abstract
Malaria is one of the main causes of mortality and morbidity in the world, endangering billions and affecting millions of
people each year. Resistance to common antimalarial drugs has proven to be a challenging problem in malaria control. In
an attempt to develop efficacious compounds against sensitive and multidrug resistant falciparum malaria, four new
complexes of mixed ligands (artemether and lumefantrine) were synthesized using template method. Their
antiplasmodial activity potential was evaluated and compared with chloroquine and the parent ligands. The compounds
were active against the tested parasite strains. The presence of the metal ions significantly improved the antiplasmodial
action against the drug-resistant parasite strains when compared to chloroquine. Additionally, their biological activity
was assessed using several in vitro assays. Biological and physical properties were correlated to the antimalarial activity.
Description
Keywords
Malaria, Metal Complexes, Antiplasmodial, Biological activity