Browsing by Author "Olawumi, H.O."
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Item Atypical chronic myeloid leukaemia in an adolescent nigerian: a case report and review of the literature(College of Medicine, Ambrose Alli University, 2017) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Adepoju, A.M.Abstract: Atypical chronic myeloid leukaemia (aCML) is a rare subtype of CML which is now regarded as a separate clinical entity and classified among the Myeloproliferative/myelodysplasic syndromes. It lacks the Philadelphia chromosome and BCR-ABL fusion gene found in the classical CML. We report a case of aCML which was diagnosed and managed at the Haematology Department of the University of Ilorin Teaching Hospital, Ilorin. Full blood count showed anaemia, leucocytosisand presence of various forms of myeloid cells with dysplastic features. Bone marrow aspiration done also showed myeloid hyperplasia with dysplastic changes in the myeloid cells. There was poor outcome in the patient. This case illustrates the importance of full haematological investigations of suspected CML cases so that the diagnosis of a CML will not be missed or passed for CML as this could influence choice of treatment and prognosis of patients. There is need for improved diagnostic facilities in tertiary health institutions in the country if we must achieve proper diagnosis and characterization of cases of aCML.Item Autologous blood donations and transfusions among patients undergoing elective orthopaedic, gynaecologic and elective caesarean section at a Tertiary Hospital in North Central Nigeria(Kenya Medical Association, 2018) Shittu, A.O.; Olawumi, H.O.; Adesina, K.T.; Babalola, O.M.; Ibraheem, G.H.; Babatunde, A.S.; Olatinwo, A.W.O.ABSTRACT Introduction: Allogeneic donor blood is becoming increasingly costly, scarce and associated with multiple risks; there is need for more conservative transfusion strategies, one of which may be adoption of Autologous Blood Donation and Transfusions (ABDT). Despite increased acceptance of ABDT by clinicians and patients in most developed world, awareness in this part of the world is still low. Materials and methods: this is a cross sectional survey of knowledge and acceptance of ABDT by patients scheduled for elective orthopaedic, gynaecologic and elective caesarean section surgeries using structured interviewer administered questionnaire on socio-demographics, clinical presentations, knowledge of blood donations and transfusions, and acceptance of ABDT. The study population comprised of 171 subjects. Results: Gynaecologic/obstetric patients were 120 (70.2%) while 51 (29.8%) of the subjects were Orthopaedic patients. Majority (43.95%) were within the age range 31-45 years, 38.6% were less than 31 years while 17.5% were older than 45 years. Females constituted the larger proportion (77.2%). Twenty one (12.3%) subjects had donated blood in the past, 45 (26.3%) had previous blood transfusions and 30 (17.5%) had knowledge of ABDT. Eight one (47.4%) of all subjects accepted ABDT for the scheduled surgeries while 123 (71.9%) subjects accepted to be voluntary blood donors after surgery. Pre-deposit is the commonest form of ABDT preferred by the subjects (66%), followed by Haemodilution (28%) and Cell salvage (6%). February 2018 EAST AFRICAN MEDICAL JOURNAL 1215 significant number of the subjects who accepted ABDT were ready to become voluntary blood donors after surgery (90.1%). Conclusion: Acceptance rate as high as 47.4% was recorded in this study despite low awareness. This is higher than what was reported by most authors’ locally but similar to the findings from Europe and Asia. Pre-deposit form was the commonest ABDT acceptable to these patients. Improving awareness on ABDT will boost voluntary blood donations and improve blood transfusion safety.Item Beta- Thalassaemia Trait Screening Using Capillary Electrophoresis Among Voluntary Blood Donor in North Central Nigeria(College of Health Sciences, University of Ilorin, Ilorin, Nigeria., 2021-01) Durotoye, I A.; Salaudeen, AG; Sanni, E.O; Babatunde, A.S; Adekunle, D.K; Akande, T.M; Olawumi, H.O.; Musa, O.IBeta-thalassaemia(â-thalassaemia) carriers exists in malaria endemic zones of sub-Sahara Africa including Nigeria. Studies on â-thalassaemia in Nigeria are few in the literature. The high variation in the prevalence of â-thalassaemia in Nigeria as reported in previous studies raises concern. Newer screening techniques such as capillary electrophoresis is now being used in clinical laboratories. This study screened for â-Thalassaemia carriers among voluntary blood donors using capillary electrophoresis. A descriptive cross-sectional study was conducted among 100 voluntary blood donors among students of Kwara State Polytechnic, Ilorin, Nigeria with age range of 18-34years. The participants consist of 55 males (55%) and 45 females (45%). Capillary electrophoresis using the Minicap system was used for determining the Haemoglobin A2 and F quantification in alkaline buffer (PH 9.4). Data analysis was done using SPSS and p-value<0.05 was taken as the level of significance The mean age of the participants was 22.23 ± 3.3 SD years(mean age of males 23±3.3 and females 20±2.8) The mean HbA2 among the participants was 3.49± 0.9SD (Range 0.8-5.30%). The mean HbF was 1.43± 0.57SD (Range 0.80-2.50%). Three (3/100) of the subjects had both elevated HbA2 > 3.9% and HbF >1%, giving a prevalence of 3% for â thalassaemia >1%, giving a prevalence of 3% for â thalassaemia carriers among blood donors in this study. The prevalence of â thalassaemia carrier was 3% in our study and found among female folks. Data from this study will be useful in raising awareness and genetic counseling especially among female blood donors.Item Changing pattern of haematological malignancies in Ilorin, Nigeria: A 10 year retrospective review of 181 cases(Ambrose Alli University, 2016) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Akinwumi, O.O.Abstract The global burden of cancer has been reported to be on the increase and haematological malignancies (HM) are not exceptions to this observed trend. The aim of this study was to carry out a retrospective analysis of all cases of HM seen at the University of Ilorin Teaching Hospital, Ilorin and document the current pattern of HM and compare with previous reports from Nigeria and elsewhere. Materials used for the study were obtained from the Records Cancer Registry of the University of Ilorin Teaching Hospital. A total of 181 cases of HM were diagnosed and managed within the study period constituting 8.1% of all cancer cases and 0.2% of all hospital admissions. The ages of patients with HM ranged from 7 months to 80 years. There were 116 (64.1%) males and 65 (35.9%) females. The various HM recorded in the study were: ALL 17(9.4%), AML 23(12.7%), CLL 33(18.2%), CML 46(25.4%), NHL 33(18.2%), HL 7(3.9%), BL 2(1.1%) and MM 20(11.0%). CML was the commonest HM observed in this study. NHL was the commonest lymphoma encountered constituting 82.5% of all the lymphoma cases. This study demonstrated that haematological malignancies are common in this environment. Availability of improved diagnostic facilities, improved blood transfusion services, early presentation and better referral system from other health facilities to our centre may have contributed to the improved mean survival of patients with HM observed in this study.Item Comparative Analysis of Baseline and One Year Post HAART Haematological Parameters in HIV Infected Patients in Ilorin, Nigeria(Sikkim Manipal University, 2017) Olawumi, H.O.; Babatunde, A.S.; Adepoju, A.M.; Omokanye, K.O.; Jayeola, A.A.; Ogunfemi, M.K.; Oladosu-Olayiwola, O.R.Abstract:Haematological abnormalities are common manifestations of HIV infection. The aim of this study was to determine the effect of HAART on haematological parameters of HIV infected patients.This was a longitudinal prospective study conducted at the HAART clinic of University of Ilorin Teaching Hospital, Ilorin. Eighty newly diagnosed HIV positive patients between 21-75 years who were planned to commence HAART (lamivudine, zidovudine and nevirapine) were recruited into this study. Baseline and one year post- HAART full blood count were carried out by Sysmex KX21 according to manufacturer’s instructions.Twenty nine percent of the patients had anaemia, 13% had neutropaenia and 0.02% had thrombocytopaenia at presentation. There was a significant increase in mean hemoglobin concentration of the patients from 10.79±1.89g/dl at baseline to 11.52±1.27g/dl at one year post HAART initiation. (P value=0.003) There was a statistically significant difference in mean baseline haemoglobin concentration of patients in WHO clinical stages 1, 2 and 3(11.67±1.39g/dl, 10.47±2.09g/dl, 10.00±1.86g/dl respectively; P=0.012). HIV patients were more likely to present with anaemia followed by neutropaenia and rarely thrombocytopaenia. Severity of anaemia increased with disease progression. HAART led to improvement in haematological abnormalities with significant increase in haemoglobin concentration. Haemoglobin concentration may therefore be used to monitor response to HAART in HIV infected patients.Item Current Trend of Transfusion Transmissible Infections among Voluntary Blood Donors in North Central Nigeria(College of Health Sciences, University of Ilorin, 2021-07) Durotoye, I.A.; Salaudeen, A.G.; Sanni, E.O.; Durowade, K.A.; Babatunde, A.S.; Olawumi, H.O.; Akande, T.M.; Musa, I.O.Blood transfusion is an integral part of modem medicine which had saved many lives which would have been lost as a result of lack of blood. Although blood is needed for survival, it can also be a medium for the transmission of harmful infectious diseases. This study evaluated current trend of transfusion transmissible infections among voluntary blood donors in Nigeria. This was a descriptive community-based study involving 600 prospective voluntary blood donors among staff and students of 5 tertiary institutions in Kwara and Kogi States. Hepatitis B surface antigen and Hepatitis C antibodies were screened for using Hepatitis B Virus Surface Antigen Bio-Inteco ELISA KIT, and Anti-HCV Bio-Inteco ELISA KIT, respectively. Screening for HIV was done with Enzyme immunoassay method using Human Immunodeficiency Virus (HIV) 1+2 Antigen Antibody ELISA KIT, product of Bio-Inteco HIV Diagnostics, UK. Testing for Syphilis was carried out using Rapid Plasma Reagin (RRR) test. Statistical analysis was done with IBM SPSS version 20. Level of significance was set at p< 0.05 The mean age of the subjects was 21.98 ± 5.17 years. Two thirds of the prospective blood donors were within the second decade of life and more than half were males. The prevalence of Hepatitis B among subjects were 4.7%, Hepatitis C,0.2%, HIV 1% and Syphilis 0%. The prevalence of hepatitis B and HIV were relatively high compared to Hepatitis C and Syphilis among voluntary blood donors, although lower than the prevalence among general population in Nigeria. In order to improve on blood transfusion safety, there is a need to increase public awareness on vaccination for hepatitis B virus, Quality control of screening methods and rational use of Blood.Item Determination of Normal and Variant Hemoglobin using Capillary Electrophoresis among Voluntary Blood Donors in North Central Nigeria: Implications on Blood Transfusion Services(Faculty of Medicine and Health Sciences, Omdurman Islamic University, Sudan, 2021-03-31) Durotoye, I A.; Salaudeen, AG; Sanni, E.O; Babatunde, A.S; Durowade, A.K; Olawumi, H.O.; Akande, T.M; Musa, O.IBackground: Voluntary non-remunerated blood donation is a strategy adopted by World Health Organization aimed at ensuring safety and adequacy of blood supply. Sub-Saharan Africa has a high prevalence of hemoglobin disorders and therefore needs to adopt stringent measures in donor selection to ensure safety for the recipient of blood transfusion. This study aimed to analyze normal and variant hemoglobin among voluntary blood donors. Methods: In this descriptive cross-sectional study, 100 prospective blood donors including 55 (55%) males and 45 (45%) females, aged 18–34 years were recruited. Capillary electrophoresis using the Minicap system was used for determining the hemoglobin variants in alkaline buffer (PH 9.4). Data analysis was done using SPSS version 20 and p-value < 0.05 was considered as the level of significance Results: The mean age of the participants was 22.23 ± 3.3 SD years. The proportion of participants with genotype AA was 67 (67%), those with AS were 17 (22 %), while those with AC were 11 (11 %). While Hb A ≥ 90% was noted in 67 (67%) blood donors, Hb S was seen in 22 (22%) and Hb A2 > 3.5% in 57 (57%). Hb F > 2% was observed in 3% of the studied participants Conclusion: Variant hemoglobin is common among blood donors and this should be taken into consideration whenever blood is being crossmatched for recipients of blood transfusion. Data from this study will be useful in raising awareness and genetic counseling.Item Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria(Makerere University School of Medicine. College of Health Sciences, Kampala, Uganda, 2018-09-03) Oladosu-olayiwola, OR; Olawumi, H.O.; Babatunde, A.S; Ijaiya, M; Durotoye, I A.; Biliaminu, A.S; Ibraheem, R.M.Background: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study com- pares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results: The mean age of the respondents was 29.9±5.2 years. The median(25 th -75 th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000-1560.000ng/ml), 0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respec- tively which were significantly higher than the corresponding values in the controls of 520 (24.000-1030.000ng/ml), 0.05 (0.040-0.090ng/ml and 2.650 (2.125-3.400ng/ml) respectively, p<0.05 each. Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.Item Haematological Parameters of Normal Pregnant Women During Antenatal Clinic Booking in Ilorin, North Central Nigeria(Ambrose Alli University, 2017) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Adesina, K.T.; Sani, M.A.; Nyamgee, AAlterations in the values of some haematological parameters like packed cell volume and haemoglobin concentration during pregnancy have been reported to significantly influence pregnancy outcome. The aim of this study was to determine the values of haematological parameters in apparently healthy pregnant women during the antenatal clinic booking visit at the University of Ilorin Teaching Hospital, Ilorin, North central Nigeria. A total of 298 apparently healthy pregnant women who presented for antenatal care booking and satisfied the inclusion criteria were included in the study. There were 64 (21.5%) women in first trimester, 146 (49.0%) women in second trimester and 88 (29.5%) in third trimester; and were aged between 22 and 42 years. Packed cell volume, haemoglobin concentration, Red cell count, mean haemoglobin concentration, mean corpuscular volume, mean corpuscular haemoglobin concentration, Total white blood cell count and differentials, Platelet count and erythrocyte sedimentation rate were carried out in the subjects. The overall mean values and SD of the pregnant women for the haematological parameters were as follows: PCV (32.76±2.18%), Hb (10.82±0.77g/dl), RBC (3.87±2.32 x1012/L), MCH (28.08±2.06 pg), MCV (85.16±5.82 fl), MCHC (33.01±1.05 g/dl), TWBC (7.35±2.62 x109/L), Platelet count (192.15±62.80 x109/L) and ESR (34.07±16.85 mm/hr). There were statistically significant differences in the mean values of PCV, MCH and MCV with increasing gestational age (p<0.05). Conclusion: The present study provides a baseline data on the haematological values in pregnancy in the North central zone of the country on which further large scale studies in future may be based. This study will also be of immense benefit in the monitoring of pregnant women to determine those at risk for timely intervention thereby improving pregnancy outcome.Item Haemostatic Parameters During Pregnancy In Ilorin, Nigeria(College of Health Sciences (A WHO Collaborating Centre for Research and Manpower Development), University of Ilorin, 2012-07) Durotoye, I A.; Babatunde, A.S; Olawumi, H.O.; Olatunji, P.O; Adewuyi, J.OThe objective of this study was to document the effect of pregnancy on some haemostatic parameters (Prothrombin time [PT], activated partial thromboplastin time [APTT], fibrinogen concentration, euglobin clot lysis time [ELT], and platelet count) in different trimesters of pregnancy. One hundred and eighty women with non-complicated pregnancy within the age range of 17-40 years (mean± SD 27.1±3.9years) were recruited for the study and sixty non-pregnant, normotensive apparently healthy age-matched women were used as control. All haemostatic parameters evaluated were determined using standard techniques. Significant differences were observed between the haemostatic parameters studied and controls except for platelet count. Prothrombin time was significantly shorter (p<0.001) and fibrinogen significantly higher (p<0.001) as pregnancy advanced but, other parameters were not influenced by the gestational age. There was a significant difference between the fibrinogen level in older subject compared with subject of younger age group with a mean of 5.5g/l and 4.0g/l (p<0.05) respectively. There was no significant relationship in the haemostatic parameters with parity and educational level of all the subjects. In conclusion, the results of haemostatic screening tests in this study suggest some degree of activation in pregnant women.Item Open Heart Surgery in Ilorin: Case Report and Experience with the First Two Cases(College of Health Sciences, University of Ilorin, Nigeria, 2017) Adeoye, P.O.; Abdulkadir, M.B.; Kolo, P.M.; Ige, O.A.; Afolabi, J.K.; Ogunmodede, James Ayodele; Olawumi, H.O.; Adeboye, M.A.N.; Adedoyin, O.T.Open heart surgery is uncommonly done in Nigeria and restricted to few centres despite the burden of congenital heart disease. We present our first experience with open heart surgery at the University of Ilorin Teaching Hospital. A 15 years old female adolescent presented with a 2 years history of easy fatigability, dyspnoea on exertion and chest pain. Echocardiography revealed a large ostium secundum atrial septal defect. She had patch closure of the atrial septal defect. The second case was a 7 years old female child with stunted growth. Echocardiography confirmed an ostium secundum atrial septal defect and severe pulmonary valvular stenosis. She had patch closure of the atrial septal defect and pulmonary valvulotomy. Both patients are being followed up and doing well. The hospital has achieved a major milestone by performing its first open heart surgeries. A coordinated team approach yields good results in the development of capacity and facilities for performing open heart surgery in Nigeria.Item Otologic and Audiologic Evaluation among HIV Patients in Ilorin, Nigeria.(Nigerian Quarterly Journal of Hospital Medicine. Published by University of Lagos. Medical Society, Lagos, Nigeria., 2013) Alabi, B.S.; Salami, A.K.; Afolabi, O.A.; Aremu, S.K.; Olawumi, H.O.; Odeigha, L.O.; Akande, H.J.BACKGROUND: HIV infection is the highest cause of death worldwide and presenting eventually with ENT regions. OBJECTIVE: This study is to determine the prevalence of hearing loss and hearing patterns among adults Nigerians with HIV and causal relationships between CD4+ counts with the degree of hearing impairments. METHODS: This prospective study was carried out among all consecutive HIV positive patients attending the clinic at the University of Ilorin teaching hospital (U.I.T.H.), Ilorin, Nigeria between January and July, 2008. They all had audiological assessments with a pure tone audiometer within the frequency range 250 to 8,000 Hz to determine their hearing thresholds together with their CD+ counts estimations. RESULTS: 89 were evaluated in the age range of 18 to 56 years (Mean 36.4 years, SD of 8.82) and the modal age group was 21-39 years (59.6%), 40-56 years (38.2%).There were 51 males (57.3%) and 38 females (42.7%) with a male/female ratio of 1.3:1.0. Otological symptoms included tinnitus (15.7%), vertigo (15.7%), otalgia (14.6%) and hard of hearing (10%). Examinations showed bilateral serous Otitis media (glue ear) in 58 patients (65.1%) with no affectation of the facial nerves. PTA showed mixed, conductive and SNHL in 32 patients (36%), 20 patients (22.5%), 9 patients (10.1%) respectively and only 15(16.9%) had normal hearing thresholds. The CD4+ counts ranged between 12 to 616. CD4 counts with hearing loss mostly < 300mm3. CONCLUSION: The prevalence of hearing loss is 87% among HIV infected patients, mostly mixed HLwith causal relationships between reduced CD4+ counts of less than 300/mm3 with severity of hearing loss. The hearing loss can interfere with the communication and specific knowledge vital to the development of best practices towards ensuring the inclusion of hearing impaired in HIV/AIDS prevention and treatment programmes.Item PAI-1 and tPA as markers of severity among pre-eclamptics in a tertiary institution in north central Nigeria(College of Medicine, University of Ibadan, Nigeria., 2016) Oladosu-Olayiwola, OR; Olawumi, H.O.; Babatunde, A.S; Ijaiya, M; Durotoye, I A.; Biliaminu, AS; Ibraheem, RM; Ogunfemi, MKObjectives: Endothelial dysfunction contributes to the pathogenesis of pre-eclampsia as well as increased production of some factors such as tissue plasminogen activator (tPA) and plasminogen activator inhibitor type-1 (PAI-1). These factors are said to be biomarkers of pre-eclampsia but their role in assessing the severity of pre-eclampsia is under- reported. Methodology: A cross-sectional study involving 85 subjects with pre-eclampsia. They were classified clinically as having mild or severe pre-eclampsia using ACOG classification. Blood and urine samples were collected for determining tPA, PAI-1, D-dimer and proteinuria in the two groups. Clinical and laboratory values were compared using the IBM ® SPSS 20.0 (2011) soft ware packages. Results: The mean age of the respondents was 29.9±5.2 years. Forty-five (52.9%) of the subjects had severe pre-eclampsia while 40(47.1%) had mild pre-eclampsia. The median values of tPA and PAI-1 of subjects with severe pre-eclampsia were significantly higher than the corresponding values in subjects with mild pre-eclampsia (each p=0.001). There was a positive correlation between each of the tPA and PAI-1 levels with the degree of severity of pre-eclampsia (p=0.001 each). Conclusion: Fibrinolytic proteins like tPA and PAI- 1 are useful in assessing the severity of pre- eclampsia.Item PAI-1 and tPA as markers of severity among pre-eclamptics in a tertiary institution in north central Nigeria(University of Ibadan, 2016) Oladosu - Olayiwola, O.R.; Olawumi, H.O.; Babatunde, A.S.; Ijaiya, M.; Durotoye, I.A.; Biliaminu, A.S.; Ibraheem, R.M.; Ogunfemi, M.K.Objectives: Endothelial dysfunction contributes to the pathogenesis of pre-eclampsia as well as increased production of some factors such as tissue plasminogen activator (tPA) and plasminogen activator inhibitor type1 (PAI-1). These factors are said to be biomarkers of pre-eclampsia but their role in assessing the severity of pre-eclampsia is under-reported. Methodology: A cross-sectional study involving 85 subjects with pre-eclampsia. They were classified clinically as having mild or severe pre-eclampsia using ACOG classification. Blood and urine samples were collected for determining tPA, PAI-1, D-dimer and proteinuria in the two groups. Clinical and laboratory values were compared using the IBM®SPSS 20.0 (2011) soft ware packages. Results: The mean age of the respondents was 29.9±5.2 years. Forty-five (52.9%) of the subjects had severe pre-eclampsia while 40(47.1%) had mild pre-eclampsia. The median values of tPA and PAI-1 of subjects with severe pre-eclampsia were significantly higher than the corresponding values in subjects with mild preeclampsia (each p=0.001). There was a positive correlation between each of the tPA and PAI-1 levels with the degree of severity of pre-eclampsia (p=0.001 each). Conclusion: Fibrinolytic proteins like tPA and PAI-1 are useful in assessing the severity of pre-eclampsia.Item Pattern of Haematological Changes in Patients with Chronic Kidney Disease Attending Nephrology Clinic in a Tertiary Hospital in North Central Nigeria(Amber Publication Ltd, 2020) Sanni, E.O.; Olawumi, H.O.; Durotoye, I.A.; Babatunde, A.S.; Shittu, A.O.; Biliaminu, S.A.; Omokanye, K.O.; Ogunfemi, M.K.; Akinwumi, O.O.; Oyedepo, D.; Dane, S.Introduction: The impact of the disease of the kidney is enormous in developing countries like Nigeria. With the increasing use of erythropoietin stimulating agents in anaemic patients with CKD, there is a need to evaluate the changes in haematological parameters in these patients. This study assessed the haematological changes in patients with known chronic kidney disease. Materials and methods: Our research was a cross-sectional study that assessed and compared the haematologic parameters of 113 patients who had established chronic kidney disease and 113 -healthy controls who were age–and sex-matched. The full blood count (FBC) was determined by SysmexKX21(Sysmex, Japan). The test of significance was set at a P- value of <0.05. Results and Discussion: The mean age of patients with CKD was 55.00 + 15.37 years, whilst that of controls was 52.73±13.59 years. (p-value 0.240) The values of the mean of the Hb and RBC among the patients were 9.69+ 2.25g/dl and 3.62 ± 0.92 x 1012/L respectively and were found to be significantly lower than that seen among controls (13.62 ± 1.45 and 4.94 ± 0.62 respectively) with a P-value<0.001. Significantly higher values of the mean WBC and platelet count were found in the patients when compared with the control participants (p-value<0.001). A significant proportion of our patients had microcytic hypochromic anaemia (32%). Conclusion: Careful evaluation of the cause of anaemia and urgent interventions are needed in the managements of these patients.Item Pattern of neurological complications of chronic myeloid leukaemia in Ilorin, Nigeria: A ten year review(Faculty of Clinical Sciences, College of Medicine, Ambrose Alli University, 2018) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Sanni, E.O.; Oyeleke, S.A.Aim and Objective: The study was carried out to document the pattern of neurological complications seen in patients with chronic myeloid leukemia who were managed at the University of Ilorin Teaching Hospital, Ilorin and compare with previous reports from other parts of Nigeria and elsewhere. Materials and Methods: A ten year retrospective analysis of all cases of CML managed at the study centre between January 2006 and December 2015 was carried out. Case folders of all patients diagnosed with CML during the study period, and the Malignancy registers of the Haematology department were retrieved and analyzed. Relevant information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. Results: Thirty six (36) patients were diagnosed with CML during the study period. There were 21 (58.3%) males and 15 (41.7%) females, giving a male: female ratio of 1.4:1.The mean age of the patients at diagnosis was 37.5 years (range, 11-75 years). Nine (25%) patients presented with various forms of neurological complications and the mean WBC count in them was 383.2 x 109/L (280.5 601.0 x 109/L). Auditory complications were the commonest neurological deficits found in 6(66.7%) of the 9 patients with neurological manifestations. Conclusion: The neurological complications recorded in this study were similar to those reported in previous studies from Nigeria and other countries. These complications need to be looked for at presentation and adequately characterized as their presence could significantly influence the prognosis of the disease and decisions on management modalities.Item PATTERN OF NEUROLOGICAL COMPLICATIONS OF CHRONIC MYELOID LEUKAEMIA IN ILORIN, NIGERIA: A TEN YEAR REVIEW(Faculty of Clinical Science, Ambrose Alli University, Ekpoma, Nigeria., 2018) Babatunde, A.S; Olawumi, H.O.; Durotoye, I A.; Shittu, E.O; Oyeleke, S.AAim and Objective: The study was carried out to document the pattern of neurological complications seen in patients with chronic myeloid leukemia who were managed at the University of Ilorin Teaching Hospital, Ilorin and compare with previous reports from other parts of Nigeria and elsewhere. Materials and Methods: A ten year retrospective analysis of all cases of CML managed at the study centre between January 2006 and December 2015 was carried out. Case folders of all patients diagnosed with CML during the study period, and the Malignancy registers of the Haematology department were retrieved and analyzed. Relevant information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. Results: Thirty six (36) patients were diagnosed with CML during the study period. There were 21 (58.3%) males and 15 (41.7%) females, giving a male: female ratio of 1.4:1.The mean age of the patients at diagnosis was 37.5 years (range, 11-75 years). Nine (25%) patients presented with various forms of neurological complications and the mean WBC count in them was 383.2 x 109/L (280.5 601.0 x 109/L). Auditory complications were the commonest neurological deficits found in 6(66.7%) of the 9 patients with neurological manifestations. Conclusion: The neurological complications recorded in this study were similar to those reported in previous studies from Nigeria and other countries. These complications need to be looked for at presentation and adequately characterized as their presence could significantly influence the prognosis of the disease and decisions on management modalities.Item Prevalence and Trend of HBsAg, Anti-HCV and Anti-HIV among Blood Donors in a Tertiary Hospital in North Central Nigeria(Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok., 2017-01-01) Olawumi, H.O.; Shittu, A.O.; Durotoye, I A.A major risk of blood transfusion is the acquisition of one or more of the transfusion transmissible infections. This risk correlates with the prevalence of markers of these infections in the donor population. The aim of the study was therefore to determine the prevalence and trend of HBsAg, HIV and HCV among blood donors in Ilorin. The screening records of prospective, mainly family replacement donors from January 2011 to December 2015 were retrospectively evaluated. All screenings were done by ELISA method using kits manufactured by Inteco Diagnostics, England, United Kingdom according to manufacturer’s instructions.36889 prospective donors were screened over the five year period. Seroprevalence of HBsAg, HIV and HCV was 12.9%, 2.2% and 1.9% respectively. There was a gradual decline in the prevalence of HBsAg from13.5% in 2011 to 11.3% in 2015, HIV prevalence similarly declined from 3.2% in 2011 to 1.2% 2015, HCV prevalence fluctuated throughout the 5 year period. Although the prevalence of TTI among blood donors is generally on the decline, it is still substantially high especially that of HBV. This exposes transfused patients to a substantial risk. There is therefore the need to slow down on blood transfusion and adopt the practice of weighing the risks and benefits before decision to transfuse any patient.Item Prevalence of Anaemia among Pregnant Women at Antenatal Care Booking in Ilorin, North Central Nigeria(College of Health Sciences, University of Ilorin, 2017) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Adesina, K.T.; Sanni, M.A.Abstract: Anaemia is a global health problem which commonly affects women and children most especially in the developing countries. Anaemia in pregnancy is the most common haematological condition encountered among pregnant women in most developing countries including Nigeria. This prospective study was carried out to determine the red blood cell indices (PCV, Hb, RBC, MCH, MCV, MCHC) and the prevalence of anaemia among pregnant women attending the University of Ilorin Teaching Hospital, Ilorin. A total of 298 women who presented for booking at the antenatal clinic at different levels of pregnancy were enrolled in the study. There were 64 (21.5%) women in first trimester, 146 (49.0%) women in second trimester and 88 (29.5%) in third trimester The mean age of the women was 25.8±3.2 years, and their ages ranged between 18-42 years. One hundred and eighty pregnant women had haemoglobin concentration < 11.0g/dl giving a prevalence rate of anaemia of 60.4%. Mild anaemia was found in 105 (58.3%), moderate anaemia in 72 (40.0%) and anaemia in 3(1.7%) of the pregnant women. There was significant correlation between anaemia and gestational age, parity and level of education at booking. This study indicated presence of high prevalence of anaemia in pregnancy and there is need for appropriate interventional strategies to be put in place so as to reduce prevalence of anaemia and improve pregnancy outcome in our environmentItem Prevalence of antibody to hepatitis B core antigen among hepatitis B surface antigen-negative blood donors in Ilorin, Nigeria(Malawi Medical Association, Malawi, 2017-03) Ogunfemi, M.K; Olawumi, H.O.; Olokoba, A.B; Kagu, M.B; Biliaminu, K.A; Durowade, K.A; Durotoye, I A.; Shittu, A.O.Background Post-transfusion hepatitis occurs even with stringent donor selection criteria and screening for hepatitis B surface antigen (HBsAg). The objective of this study was to determine the prevalence of antibody to hepatitis B core antigen (anti-HBc) in HBsAg-negative blood donors. Methods This was a cross-sectional study in which 200 HBsAg-negative blood donors were recruited. Screening for viral markers was done using both a rapid test kit and enzyme-linked immunosorbent assay (ELISA) for anti-HBc IgM. Quantitative and qualitative analysis of anti-HBc IgM was done by “capture” enzyme immunoassay using DIA.PRO HBc IgM test kit. The other viral markers were investigated using one step cassette style HBV tests. SPSS (version 16) was used for data analysis. A P-value of 0.05 or less was considered significant. Results There were 190 male (95%) and 10 female (5%) blood donors, with a mean age of 31.7 ± 7.9 years. The prevalence of anti-HBc IgM was 4%. The other viral markers (HBeAg, anti-HBeAg, anti-HBs and total anti-HBc) had a prevalence of 1.5%, 23%, 2.5%, and 32.5%, respectively. Conclusions The prevalence of anti-HBc IgM in this study wsa high, and this supports the fact that screening blood donors for HBsAg alone is not sufficient to prevent transmission of HBV.