Browsing by Author "Dele-Ojo, B.F"
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Item Acute Rapid QTc Changes Following Chloroquine Overdose with No Suicidal Intent(The Biomedical Communications Consult, 2020) Ogunmodede, James Ayodele; Ogunmodede, A.J.; Dele-Ojo, B.F; Buhari, O.I.NWe report a 39 year-old male with unintentional chloroquine overdose without any suicidal intention. Marked QTc prolongation of 0.508sec was observed acutely though patient’s total ingested dose was lower than most fatal doses reported in literature. This range of QTc carries a predisposition to potentially fatal ventricular arrhythmias. Serial electrocardiograms (ECGs) demonstrated gradual return of QTc towards normal while patient was on observation without any indication for active intervention. We recommend that in the event of chloroquine overdose, close monitoring of the cardiovascular system should be done even in apparently stable individuals.Item Association between blood pressure dipping patterns and hypertension-mediated organ damage among Nigerians with newly diagnosed hypertension.(College of Health Sciences, Osun state University, Osogbo., 2021) Dele-Ojo, B.F; Ogunmodede, James Ayodele; Ojo, O.D; Kolo, P.M.; Katibi, I.A.; Omotoso, A.B.; Adeoye, M.A; Adesokan, Abstract Introduction: Abnormal blood pressure (BP) dipping patterns are associated with increased cardiovascular risk among Africans. This study determined the association between BP dipping patterns and hypertension-mediated organ damage among patients with newly-diagnosed hypertension. Methods: Ambulatory BP monitoring and echocardiography were carried out on 120 participants. Participants were categorized based on the ratio of night-time to day-time systolic BP into 4 patterns: Normal dipper (≥ 10% but < 20%), non-dippers (≥ 0% but < 10%), reverse dippers (<0%) and extreme dippers (≥ 20%). Result: Fifty-one (42.5%) were males, the mean age and body mass index were 44.2±9.8years and 27.1±4.4kg/m2 respectively. The non-dipping pattern was the most prevalent while the reverse dipping had the lowest mitral E/A ratio. Office systolic blood pressure was the only predictor of left ventricular hypertrophy (OR=1.050, 95% CI=1.004-1.098; p-value = 0.034). Conclusions: The non-dipping pattern was the most prevalent abnormal dipping pattern while the reverse dippers had the highest risk of hypertension-mediated organ damage. Office blood pressure was the only predictor of left ventricular hypertrophy. Hence, office BP measurement as well as ambulatory blood pressure measurements are potentially important tools in risk stratification in resource-poor settings of sub-Saharan Africa.Item Association between Blood Pressure Dipping Patterns and Left Ventricular Hypertrophy among Apparently Healthy Normotensive Nigerians.(College of Health Sciences, Ekiti state University, Ado-Ekiti., 2021) Dele-Ojo, B.F; Ogunmodede, James Ayodele; Ojo, O.Dackground Abnormal blood pressure dipping pattern has been associated left ventricular hypertrophy among Africans with systemic hypertension. However, more studies are required to show whether abnormal blood pressure (BP) dipping patterns are associated with left ventricular hypertrophy (LVH) in healthy normotensive patients. This study determined the association between BP dipping patterns and left ventricular hypertrophy among normotensive Nigerians. Methods This was a cross-sectional study in which 120 normotensive individuals with no co-morbidities had ambulatory blood pressure monitoring (ABPM) and echocardiography. We defined extreme dippers, normal dippers, non-dippers and reverse dippers as nocturnal systolic BP decline of (≥ 20%), (10% to 19%), (0 to 9%) and (<0%) respectively. Results Fifty-four (45%) were males, the mean age and body mass index were 37.0 ± 10.1years and 24.0 ±4.2 kg/m2 respectively. Sixty-nine (57.5%) were non-dippers and 71 (59.2%) had LVH. Reverse dippers had the highest left ventricular mass index, it was not statistically significant. Binary logistic regression showed age as the only predictor of left ventricular hypertrophy (OR=1.055, 95% CI=1.004-1.109; p-value = 0.033). Conclusions A high prevalence of non-dipping pattern and left ventricular hypertrophy was found among apparently healthy Nigerian normotensives. Increasing age was the only predictor of LVH in our study population. Hence, ABPM and echocardiography are recommended to accurately assess cardiovascular risk in apparently healthy Nigerian normotensives.Item Benefits, disadvantages and challenges of virtual conferencing in the covid-19 era: adjusting to the new normal.(College of Health Sciences, Osun state University, Osogbo., 2022) Ogunmodede, James Ayodele; Ogunmodede, A.J.; Dele-Ojo, B.F; Omotoso, A.B.; Agede, O.A.; Buhari, O.I.N; Omotoso, A.B.OObjective: The COVID-19 pandemic has had tremendous effect on the medical and scientific community. Measures instituted to curb the spread of the disease such as physical distancing and ban on large gatherings have significantly altered conferencing activities of medical professional associations. With no end in sight to the pandemic, it is certain that medical professional associations may have to make do with purely virtual or hybrid conferencing for some time to come. The objective of this paper is to highlight the benefits, disadvantages and challenges of virtual conferencing Methods: We searched Pubmed, Embase, Scopus, and AJOL databases from January 1, 2021 to December 31, 2021 for publications describing the benefits, disadvantages and challenges of virtual conferencing during the pandemic. This, together with authors' experience formed the resource base for this work. Conclusion: We propose ways the scientific community in Nigeria can maximize the virtual conferencing while the pandemic lasts. We also advocate increased discussion about how to improve the virtual conferencing culture and the development of guidelines for purely virtual or hybrid scientific conferences.Item Characteristics of patients with acute heart failure in North Central Nigeria.(College of Health Sciences, Osun state University, Osogbo., 2021) Ogunmodede, James Ayodele; Kolo, P.M.; Bojuwoye, M.O.; Dele-Ojo, B.F; Ogunmodede, A.J.; Kolo, P,M., Omotoso, A.B.O.Objectives: Heart failure (HF) is an important cause of hospital admission in Nigeria. HF is increasingly prevalent because the population is aging and HF epidemiology is changing. We aimed at profiling the socio-demographic, clinical and echocardiographic (Echo) characteristics of patients admitted for acute HF. This is one of the largest cohorts of HF patients profiled in Nigeria so far. Methods: Cross sectional design. Socio-demographic, clinical and Echo data were collected from 455 patients admitted for AHF at University of Ilorin Teaching Hospital, North central, Nigeria. Results: Mean age of patients was 58.9± 15.7years, (men were older than women, P= 0.006). 265(58.2%) were males, most patients were aged >60 years, 4.8% had pre-existing Type2 Diabetes mellitus. 53.2% of patients presented in New York Heart Association StagesIII and IV. Median duration of admission was 11days (IQR, 6-17), intrahospital mortality- 11.6%. Hypertension was the commonest aetiological factor (62.4%), followed by dilated cardiomyopathy 17.6%, rheumatic heart disease (6.6%), Peripartum cardiomyopathy (5.3%), and others. Conclusion: AHF patients in our study are older than those in previous studies in Nigeria and sub-Saharan Africa. Hypertension is main driver of AHF, and patients largely present with clinically advanced disease necessitating stronger public health education about risk factors and early presentation.Item The Indirect victims of COVID-19: perception of non- COVID-19 patients about the effect of closure of the medical outpatient services on their health.(West African College Of Physicians, 2022) Ogunmodede, James Ayodele; Ogunmodede, A.J.; Dele-Ojo, B.F; Bello, A.H.; Bolarinwa, O.A.; Bojuwoye, M.O.; Yusuf, I.A.; Abiola, T.S; Olokoba, A.B.; Kolo, P.M.BACKGROUND: In order to reduce COVID-19 transmission and protect healthcare workers, the outpatient departments (OPDs) in many hospitals worldwide were closed down in the early days of the pandemic. Patients being managed for chronic medical illnesses who subsequently suffered reduced access to healthcare have been described as “the patients left behind”. AIM: The study aimed at assessing the impact of the closure of the Medical OPD in University of Ilorin Teaching Hospital (UITH) on the health and perceived well-being of patients with chronic medical illnesses. METHODS: A cross-sectional study of 180 patients with chronic medical illnesses attending the MOPD in UITH. RESULTS: Mean age of participants was 50.2±18.2years, 92 (51.1%) were male, median duration of attending MOPD was 21 months (IQR 12-36). 92 patients (51.1%) perceived a negative affectation of their well-being by the closure of MOPD. Being >50 years was associated with a perception of negative affectation of well-being (P=0.042). 140 patients (77.8%) had clinic appointments that fell within the period under review. 67(69.3%) of the 97 patients who had medical complaints during the period could not reach a doctor and this was associated with a perception of negative affectation of their wellbeing. The commonest action they took was to do nothing (28.3%), three (4.5%) resorted to herbal concoctions. 19 (29.9%) felt their complaints were urgent. CONCLUSION: Our study identifies that patients with chronic medical illness are potential victims of COVID-19 related disruption of healthcare services. Healthcare managers in Nigeria must develop alternatives such as telemedicine that sustain face-to-face medical interaction during eventualities.Item Knowledge and Prevalence of Heart Disease Risk Factors Among Staff of a Tertiary Institution in Nigeria.(SAGE, 2021) Dele-Ojo, B.F; Raimi, T.H; Fadare, J.O.; Ajayi, E.A.; Ajayi, D.D.; Ogunmodede, James AyodeleBackground: Cardiovascular disease is the most common cause of mortality worldwide. Hence, awareness of cardiovascular risk factors is an essential step towards effective reduction of the disease burden. This study determined the knowledge and prevalence of cardiovascular risk factors among Staff of Ekiti State University. Ado-Ekiti, Nigeria. Methods: A cross-sectional study which comprised of 223 members of staff. Results: There were 103 males (46.2%). Low knowledge of heart disease risk factors was found in 68.6% of the respondents. The prevalence of hypertension, diabetes mellitus, overweight, obesity, physical inactivity was 35.4%, 12.1%, 31.8%, 23.3%, and 83% respectively. Family history of hypertension was a predictor of a high level of knowledge. Conclusion: A low level of knowledge and increasing prevalence of cardiovascular risk factors existed among staff of Ekiti State University, Nigeria. Hence, there should be a step-up of awareness campaigns and promotion of healthy lifestyle among this category of people.Item Public knowledge of heart attack symptoms and prevalence of self-reported cardiovascular risk factors in Ilorin, Nigeria.(Nigerian Cardiac Society, 2015) Kolo, P.M.`; Sanya, E.O.; Bello, H.S.; Gbadamosi, M.S.; Dele-Ojo, B.F; Katibi, I.A.; Omotoso, A.B.; OGUNMODEDE, James AyodeleBackground and objectives: Despite reduction in door‑to‑balloon time in the management of acute myocardial infarction (AMI), prehospital delay by the patients has remained a major concern as benefits derivable from reperfusion treatments are time dependent. This study aimed at evaluating knowledge and perception of warning signs of heart attack among civil servants in Ilorin, Nigeria. Materials and Methods: A pretested structured questionnaire was designed to obtain relevant information on knowledge and perception of heart attack symptoms; and action to be taken if one experiences the condition. Results: Questionnaires from 601 subjects consisting of 312 (51.9%) males and 289 (48.1%) females were analyzed. Although, 78% of the respondents have heard about heart attack, only 44.4% could discriminate a heart attack symptom from other conditions. Higher proportion of women (50.2%) than men (39.1%) could identify a core symptom of heart attack (P < 0.05). Similarly, higher percentage of participants 40 years and older (48.3%) were more knowledgeable than those younger than 40 years (42.9%), but the difference was not statistically significant (P > 0.05). Higher percentage of women reported prior cardiovascular disease/risk factors than men. Conclusion: We concluded that participants have low knowledge of heart attack symptoms with women being more knowledgeable than their male counterparts. There is the need for community education on heart attack warning signs and the need for early hospital presentation by affected individuals.Item Rehospitalization rate and predictors of rehospitalization in heart failure patients in north central Nigeria(College of Health Sciences, University of Ilorin, Nigeria, 2022) Ogunmodede, James Ayodele; Kolo, P.M.; Dele-Ojo, B.F; Yusuf, I.A.; Salau, I.L.; Katibi, I.A.; Omotoso, A.B.INTRODUCTION Heart failure (HF) is a major cause of morbidity and mortality worldwide. It imposes considerable strain on patients through the burden of recurrent rehospitalizations.. OBJECTIVES The objective of the study was to determine the rehospitalization rate of heart failure patients managed over a 3-year period in our Centre, identify factors predictive of rehospitalization and determine the survival curve for 6-month among our patients. METHODS A retrospective cohort study of patients with HF managed in our Hospital between 2014 and 2017. RESULTS 148 patients who had complete data were studied. 25.7% of patients were rehospitalized at least once during the study period. 16.2% were rehospitalised by 6 months. Only age was found to be predictive of 6-month rehospitalization OR 1.03, (CI 1.004-1.056), p=0.024 suggesting that every one year increase in age is predictive of a three percent increase in likelihood of rehospitalisation. The Kaplan-Meier survival curve for 6-month rehospitalization among rehospitalized patients is shown below. CONCLUSION The rehospitalization rates among our patients are slightly higher among other reported rates in our environment. In the resource-constrained setting we practice issues of treatment affordability and availability of novel medications and treatment strategies are important considerations to reduce rehospitalization in HFpatients.Item Relationship Between CD4 Count, Neutrophil-To-Lymphocyte Ratio, Platelet-To-Lymphocyte Ratio and Left Ventricular Systolic Function in HIV/AIDS Patients(Kenyan Medical Association., 2023) OGUNMODEDE, James Ayodele; Agede, O.A.; Dele-Ojo, B.F; Adeoye, O.G.; Ogunmodede, A.J.; Omotoso, A.B.OBackground: Inflammation is a cardinal feature of Human Immunodeficiency Virus (HIV) infection and accounts for most of its clinical manifestations. Cardiovascular involvement is common in HIV. Haematologic inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are elevated in some cardiovascular diseases in the non-HIV population. CD4 count correlates with left ventricular size. The relationship between haematologic inflammatory markers NLR and PLR and left ventricular (LV) systolic function and their prognostic value is not well studied in HIV patients. Objective: To determine the relationship between CD4 count, NLR and PLR and LV ejection fraction (EF) and their diagnostic value as surrogates for the occurrence of LV systolic dysfunction (LVSD) Design: Cross-sectional Setting: The Cardiology unit of the University of Ilorin Teaching Hospital (UITH), Ilorin, Nigeria Participants: 150 HIV positive patients Outcome measures: The relationship between CD4 count, NLR and PLR and LV ejection fraction (EF) and their diagnostic value for the occurrence of LV systolic dysfunction (LVSD) esults: The mean age was 37.14+8.6 years, 86 (64%) female, median duration of illness 6(0.94-24) months. NLR and PLR had a negative correlation with LV EF, the CD4 count had positive correlation. On multivariate analysis only PLR was predictive of EF. A cut-off PLR of 169.5 was only weakly discriminatory of LVSD with sensitivity of 81.3% and specificity of 72.9%, AUC 0.794. Conclusion: CD4 count, and inflammatory markers correlate with LVEF in HIV patients. Only PLR was predictive, its value as a diagnostic surrogate for LVSD needs further investigation.Item Smartphone Ownership and the Willingness to receive Mobile Health Services among Patients with Hypertension in Nigeria.(West African College Of Physicians, 2023) Dele-Ojo, B.F; Ojo, O.D; Omopariola, O.A.; Oseni, T.I.A; Ogunmodede, James Ayodele; Busari, O., Amu, E.O., Adefioye, A.BACKGROUND: There are traditional barriers to accessing quality hypertension care in sub-Saharan Africa. Mobile phone technology is increasingly being used to overcome these barriers. This study assessed smartphone ownership and the willingness to receive mobile health services among patients with hypertension in Nigeria. METHODS: Four hundred and twenty-seven (427) patients with hypertension were recruited from two tertiary health institutions in Ekiti State, Nigeria. Questionnaires were fed into the Open Data Kit form, which was used to take data on mobile phone ownership, the willingness to receive and the preferred type of mobile phone-based hypertension health care services. RESULTS: Males were 37.2%. Mean age was 60.6 ± 15.3 years. Of the participants, 48.7% owned smartphones, 21.1% had regular internet subscription on their phones, 94.8% were willing to receive and pay mobile health services. Phone calls (48.0%) and text messages (31.6%) were the most preferred modes of receiving hypertension-related health education. Age category of 45-64 years was the only predictor of willingness to receive mobile health services. CONCLUSION: All our participants owned mobile phones, with 48.7% being smartphones and almost all the participants were willing to receive and pay for mobile health services for prevention, treatment and information on hypertension. Middle age was the only predictor of willingness to receive mobile health, and the most preferred choices were through phone calls and text messages. The above information will guide in the design of favourable mHealth interventions that will be ideal for our study population