Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats
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Date
2018
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Publisher
College of Health Sciences, Osun State University
Abstract
Objectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored
the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in
cuprizone-damaged cerebellum.
Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A
received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6
mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa
oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the
cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide
dismutase (SOD) activities.
Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular
degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when
co-administered with MO.
Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in
cuprizone neurotoxicity.
Description
Keywords
demyelination, cuprizone, cerebellar damage, Moringa oleifera, oxidative enzymes
Citation
Omotoso G.O., Kadir R.E., Lewu S.F., Gbadamosi I.T., Akinlolu A.A., Adunmo G.O., Kolo R.M., Lawal M.O. & Ameen M.O. (2018): Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats. Research Journal of Health Sciences. 6(1):13-25. Published by College of Health Sciences, Osun State University. Available online at: https://www.ajol.info/index.php/rejhs/issue/view/16912