Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats

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dc.contributor.authorOmotoso G.O.
dc.contributor.authorKadir R.E.
dc.contributor.authorLewu S.F.
dc.contributor.authorGbadamosi I.T.
dc.contributor.authorAkinlolu A.A.
dc.contributor.authorAdunmo G.O.
dc.contributor.authorKolo R.M.
dc.contributor.authorLawal M.O.
dc.contributor.authorAmeen M.O.
dc.date.accessioned2025-05-02T11:33:29Z
dc.date.available2025-05-02T11:33:29Z
dc.date.issued2018
dc.description.abstractObjectives: Cuprizone is a neurotoxicant used in modeling demyelinating disorders. This study explored the effects of Moringa oleifera (MO) on oxidative, histomorphological and behavioural changes in cuprizone-damaged cerebellum. Methods: Twenty adult female Wistar rats were grouped into 4, each group having five animals. Group A received 1 ml of normal saline (Control); group B received 0.4% cuprizone; group C received 15.6 mg/kgBW Moringa oleifera leaf extract; group D received 0.4% cuprizone and 15.6 mg/kgBW Moringa oleifera, orally for 5 weeks. The animals were assessed for exploratory and locomotor activities, while the cerebellum was processed for histology and assayed for nitric oxide (NO), catalase (CAT) and superoxide dismutase (SOD) activities. Results: Cuprizone treatment caused weight reduction, disruption of Purkinje cell layer, cellular degeneration, reduction in NO, CAT and SOD activities. However, these changes were ameliorated when co-administered with MO. Conclusion: The anti-oxidative property of Moringa oleifera is responsible for its ameliorative effect in cuprizone neurotoxicity.
dc.identifier.citationOmotoso G.O., Kadir R.E., Lewu S.F., Gbadamosi I.T., Akinlolu A.A., Adunmo G.O., Kolo R.M., Lawal M.O. & Ameen M.O. (2018): Moringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats. Research Journal of Health Sciences. 6(1):13-25. Published by College of Health Sciences, Osun State University. Available online at: https://www.ajol.info/index.php/rejhs/issue/view/16912
dc.identifier.issn2467-8252
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15887
dc.language.isoen
dc.publisherCollege of Health Sciences, Osun State University
dc.relation.ispartofseriesVol 6, Issue 1; 13-25
dc.subjectdemyelination
dc.subjectcuprizone
dc.subjectcerebellar damage
dc.subjectMoringa oleifera
dc.subjectoxidative enzymes
dc.titleMoringa oleifera ameliorates cuprizone-induced cerebellar damage in adult female rats
dc.typeArticle

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