Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth.
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Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis.
Abstract
Gongronema latifolium Benth (Asclepiadaceae) is an edible-green-leafy vegetable with known medicinal value. A chemical investigation of the 80% methanolic extract of the leaves led to the isolation of a new pregnane glycoside: iloneoside (3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→14)-β-D-oleandropyranosyl]-11,12-di-O-tigloyl-17β-marsdenin), together with four known constituents. Their chemical structures were determined by spectroscopic analysis. The isolates were tested for their in vitro growth inhibitory activity against human leukemia HL-60 cells. Iloneoside was the most active and gave apoptotic response. Molecular docking analysis demonstrated that iloneoside could be accommodated within hot spots of anti-apoptotic protein Bcl-2. These results suggest G. latifolium as a reliable source of potent anticancer compounds.
Description
Keywords
Benth, antileukemic activity, iloneoside, pregnane glycoside, tigloyl group
Citation
Gyebi, G.A., Adebayo, J.O., Olorundare, O.E., Pardede, A., Ninomiya, M., Afolabi, O. S., Babatunde, A.S., & Koketsu, M. (2018) Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth. Natural Product Research, 32:24, 2882-2886.