Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth.

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dc.contributor.authorGyebi, G.A.,
dc.contributor.authorAdebayo, J.O.,
dc.contributor.authorOlorundare, O.E.,
dc.contributor.authorPardede, A.,
dc.contributor.authorNinomiya, M.,
dc.contributor.authorAfolabi, O. S.,
dc.contributor.authorBabatunde, A.S.,
dc.contributor.authorKoketsu, M.
dc.date.accessioned2021-06-04T09:03:22Z
dc.date.available2021-06-04T09:03:22Z
dc.date.issued2018
dc.description.abstractGongronema latifolium Benth (Asclepiadaceae) is an edible-green-leafy vegetable with known medicinal value. A chemical investigation of the 80% methanolic extract of the leaves led to the isolation of a new pregnane glycoside: iloneoside (3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→14)-β-D-oleandropyranosyl]-11,12-di-O-tigloyl-17β-marsdenin), together with four known constituents. Their chemical structures were determined by spectroscopic analysis. The isolates were tested for their in vitro growth inhibitory activity against human leukemia HL-60 cells. Iloneoside was the most active and gave apoptotic response. Molecular docking analysis demonstrated that iloneoside could be accommodated within hot spots of anti-apoptotic protein Bcl-2. These results suggest G. latifolium as a reliable source of potent anticancer compounds.en_US
dc.identifier.citationGyebi, G.A., Adebayo, J.O., Olorundare, O.E., Pardede, A., Ninomiya, M., Afolabi, O. S., Babatunde, A.S., & Koketsu, M. (2018) Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth. Natural Product Research, 32:24, 2882-2886.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5907
dc.language.isoenen_US
dc.publisherTaylor & Francis.en_US
dc.subjectBenthen_US
dc.subjectantileukemic activityen_US
dc.subjectiloneosideen_US
dc.subjectpregnane glycosideen_US
dc.subjecttigloyl groupen_US
dc.titleIloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth.en_US
dc.typeArticleen_US

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