Comparative study of antidiarrheal potential and genotoxicity in mice exposed to corn, sorghum and millet steep liqours
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Nigerian Society for Experimental Biology
Abstract
In this study, the antidiarrheal, cytotoxic and genotoxic properties of sorghum, millet and corn
steep liquors as well as mistletoe extract in wistar rats were investigated. Comparative analysis of antidiarrheal
potentials of sorghum, millet and steep liqours with standard drug (loperamide) and oral rehydration solution
(ORS) in a castor oil-induced diarrheal model was carried out. Blood was examined for serum biochemical
parameters and genotoxic effects were investigated using micronucleus test. In the antidiarrheal test, the test
agents showed action which was significant (P<0.05). Mistletoe extract exerted maximum inhibition (55.56 %)
against defecation, whereas 44.44 % and 59.26 % inhibitions were obtained for ORS and loperamide respectively.
The genotoxicity studies of these steep liquors and mistletoe extract revealed damage to the genetic material and
alteration of the activities of some marker enzymes, which is indicative of tissue damage. Although sorghum,
millet and corn steep liquors, as well as mistletoe
Description
Keywords
Antidiarrheal, micronucleus, cytotoxicity, mistletoe, cereals
Citation
Sulaiman, A. F., Iyiola, O. A., Kazeem, M. O., Abdulfattah, S. A., Ahmed El-Imam, A. M., Jimoh, A. M., Ademola, O. J., Babalola , S.A. and Sunday-Nwaso, E.O. (2016). Comparative study of antidiarrheal potential and genotoxicity in mice exposed to corn, sorghum and millet steep liquors. Biokemistri: 28(4) : 160-169,