Comparative study of antidiarrheal potential and genotoxicity in mice exposed to corn, sorghum and millet steep liqours

Simple item page
dc.contributor.authorFaoziyat A. Sulaiman
dc.contributor.authorOluyinka A. Iyiola
dc.contributor.authorMuinat O. Kazeem
dc.contributor.authorAbdulfattah A. Sulaiman
dc.contributor.authorAmina M. Ahmed El Imam
dc.contributor.authorAdisa M. Jimoh
dc.contributor.authorOlaoluwa J. Ademola
dc.contributor.authorAdekunle S. Babalola
dc.contributor.authorElizabeth O. Sunday-Nwaso
dc.date.accessioned2026-04-29T15:41:13Z
dc.date.available2026-04-29T15:41:13Z
dc.date.issued2016
dc.description.abstractIn this study, the antidiarrheal, cytotoxic and genotoxic properties of sorghum, millet and corn steep liquors as well as mistletoe extract in wistar rats were investigated. Comparative analysis of antidiarrheal potentials of sorghum, millet and steep liqours with standard drug (loperamide) and oral rehydration solution (ORS) in a castor oil-induced diarrheal model was carried out. Blood was examined for serum biochemical parameters and genotoxic effects were investigated using micronucleus test. In the antidiarrheal test, the test agents showed action which was significant (P<0.05). Mistletoe extract exerted maximum inhibition (55.56 %) against defecation, whereas 44.44 % and 59.26 % inhibitions were obtained for ORS and loperamide respectively. The genotoxicity studies of these steep liquors and mistletoe extract revealed damage to the genetic material and alteration of the activities of some marker enzymes, which is indicative of tissue damage. Although sorghum, millet and corn steep liquors, as well as mistletoe
dc.identifier.citationSulaiman, A. F., Iyiola, O. A., Kazeem, M. O., Abdulfattah, S. A., Ahmed El-Imam, A. M., Jimoh, A. M., Ademola, O. J., Babalola , S.A. and Sunday-Nwaso, E.O. (2016). Comparative study of antidiarrheal potential and genotoxicity in mice exposed to corn, sorghum and millet steep liquors. Biokemistri: 28(4) : 160-169,
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/17802
dc.publisherNigerian Society for Experimental Biology
dc.subjectAntidiarrheal
dc.subjectmicronucleus
dc.subjectcytotoxicity
dc.subjectmistletoe
dc.subjectcereals
dc.titleComparative study of antidiarrheal potential and genotoxicity in mice exposed to corn, sorghum and millet steep liqours
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2016DiarrheaManagementwithsteepliquors.pdf
Size:
695.07 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections