Phytochemical Analyses, Antimicrobial Activities and Possible Antimicrobial Mechanism of Adansonia Digitata: An Animal Model
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Date
2022-07-01
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Alexandria Journal of Veterinary Sciences
Abstract
The advent of antibiotics recorded a huge amount of success against disease-
causing microbes. However, development of resistance to reference antibiotics
leading to increased mortality have caused critical concern in the management of
infectious diseases. Continuous search for alternative therapies has shown good
candidates in medicinal plants, although without thorough examination of
possible mechanism of action. This study assessed the phytochemical
constituents, antimicrobial activities, and possible antimicrobial mechanism of
Adansonia digitata, against Shigella flexneri, Escerichia Coli and Salmonella
enteritis. Phytochemical analyses showed that Adansonia digitata is rich
phytosterols, flavonoids, phenolics and carotenoids. Assessments of
antimicrobial activities of A. digitata revealed its effectiveness against S. flexneri,
E. coli and S. enteritis. The mechanism of antimicrobial activities of A. digitata
may involve inhibition of Gram+ and Gram- transpeptidase and dihydrofolate
reductase. The antimicrobial activities may be ascribed to the presence of
phytochemicals in A. digitata.
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Citation
Antimicrobial, vegetables, resistance, .microbes, mechanism