Antimicrobial activities of Bryophyllum pinnatum on some selected clinical isolates.
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Date
2017
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Published by Fountain University, Osogbo
Abstract
Ethanol, methanol and aqueous extracts of the leaves of Bryophyllum pinnatum obtained through cold
maceration, were screened for their antibacterial activities against selected multi-drug resistant
bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi
Staphylococcus aureus) using the agar well diffusion method. Broth dilution method was used to determine
the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the
extracts at concentrations ranging from 100mg/ml to 25mg/ml. The ethanol extract was the most
reactive while the aqueous extract showed lesser antibacterial activity. Ofloxacin was the most effective
antibiotic in the antibiotic susceptibility profiling of the test organisms. It was however evident that the
ethanol extract of Bryophyllum pinnatum has higher antibacterial efficacy on the test organisms than
Ofloxacin. Bacteriostatic and -cidal activities were exhibited by the plant extracts against the organisms
ranging from 25 – 100 × 103 μg/ml. Succinctly, Bryophyllum pinnatum possesses biologically active
constituents with explorable pharmacological potentials.
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Keywords
Antimicrobial, Bryophyllum pinnatum, Extraction solvents, minimum inhibitory concentration (MIC), minimum bactericidal concentration
Citation
Anibijuwon, I.I., Saliu, B.K., Abioye, J.A., and Gbala I.D. (2017) Antimicrobial activities of Bryophyllum pinnatum on some selected clinical isolates. Fountain Journal of Natural and Applied Sciences. 6(1): 1–8. http://wwwfountainjournals.com/index.php/FUJNAS/article/view/22