Thirty days oral Aframomum melegueta extract elicited analgesic effect but influenced cytochrome p4501BI, cardiac troponin T, testicular alfa-fetoprotein and other biomarkers in rats
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Date
2021-03
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Elsevier BV
Abstract
Ethnopharmacological relevance: Pain is the commonest symptom of a disease and the percentage of persons
manifesting one form of pain is growing globally. Aframomum melegueta (AM) is commonly used by traditional
doctors as medication for many ailments such as body pains and rheumatism because it possesses antiinflammatory, anti-allergenic, antiviral, anti-ageing and anti-tumour phytochemical agents.
Aim of the study: Traditionally a botanical remedy in the management of pain was assessed. A common tropical
plant Aframomum melegueta (AM) was evaluated for the amelioration of pain. For further pharmacologic understanding sensitive marker were used to assess the effect of the extract on the organ as a multifaceted approach
to the evaluation of safety and analgesic efficacy.
Materials and method: Sensitive biomarkers such as troponin–T (CTnT), cardiac troponin-I (CTnI), interleukinbeta (IL-β), interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-α) were evaluated using the enzyme-linked
immunosorbent assay (ELISA) method and electrocardiographic parameters were also evaluated. The dynamics of concentrations of the various subfamilies of cytochrome were also assessed using ELISA in the evaluation of thirty-day oral AM, while histopathological changes of organs were also observed.
Results: Thirty-day oral AM doses 40 mg/kg and 80 mg/kg showed analgesic potential but influenced IL-6 level,
IL-1β, TNF-α and P-LCR. Electrocardiographic parameters showed the extract had arrhythmogenic effects the
other cardiac parameters influenced was CTnT. The testicular alfa-fetoprotein and prostate specific antigen were
also influenced. There were also some histopathological changes.
Conclusions: The extract showed analgesic, anti-oxidant and anti-inflammatory potential with possible adverse
effects consistent with testicular and prostate cancers, cardiovascular complication, hepatic congestion and
cholestasis.
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Citation
K.T. Biobaku et al. Journal of Ethnopharmacology 267 (2021) 113493