Thirty days oral Aframomum melegueta extract elicited analgesic effect but influenced cytochrome p4501BI, cardiac troponin T, testicular alfa-fetoprotein and other biomarkers in rats

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dc.contributor.authorK. Talha Biobaku
dc.contributor.authorO. Mistura Azeez
dc.contributor.authorS. Adetayo Amid
dc.contributor.authorT. Nnaemeka Asogwa
dc.contributor.authorA. Abubakar Abdullahi
dc.contributor.authorO. Lukman Raji
dc.contributor.authorJ. Atata Abdulhamid
dc.date.accessioned2024-05-01T17:27:44Z
dc.date.available2024-05-01T17:27:44Z
dc.date.issued2021-03
dc.description.abstractEthnopharmacological relevance: Pain is the commonest symptom of a disease and the percentage of persons manifesting one form of pain is growing globally. Aframomum melegueta (AM) is commonly used by traditional doctors as medication for many ailments such as body pains and rheumatism because it possesses antiinflammatory, anti-allergenic, antiviral, anti-ageing and anti-tumour phytochemical agents. Aim of the study: Traditionally a botanical remedy in the management of pain was assessed. A common tropical plant Aframomum melegueta (AM) was evaluated for the amelioration of pain. For further pharmacologic understanding sensitive marker were used to assess the effect of the extract on the organ as a multifaceted approach to the evaluation of safety and analgesic efficacy. Materials and method: Sensitive biomarkers such as troponin–T (CTnT), cardiac troponin-I (CTnI), interleukinbeta (IL-β), interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-α) were evaluated using the enzyme-linked immunosorbent assay (ELISA) method and electrocardiographic parameters were also evaluated. The dynamics of concentrations of the various subfamilies of cytochrome were also assessed using ELISA in the evaluation of thirty-day oral AM, while histopathological changes of organs were also observed. Results: Thirty-day oral AM doses 40 mg/kg and 80 mg/kg showed analgesic potential but influenced IL-6 level, IL-1β, TNF-α and P-LCR. Electrocardiographic parameters showed the extract had arrhythmogenic effects the other cardiac parameters influenced was CTnT. The testicular alfa-fetoprotein and prostate specific antigen were also influenced. There were also some histopathological changes. Conclusions: The extract showed analgesic, anti-oxidant and anti-inflammatory potential with possible adverse effects consistent with testicular and prostate cancers, cardiovascular complication, hepatic congestion and cholestasis.
dc.identifier.citationK.T. Biobaku et al. Journal of Ethnopharmacology 267 (2021) 113493
dc.identifier.doi10.1016/j.jep.2020.113493
dc.identifier.issn0378-8741
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/13158
dc.language.isoen
dc.publisherElsevier BV
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofseries267; 113493
dc.titleThirty days oral Aframomum melegueta extract elicited analgesic effect but influenced cytochrome p4501BI, cardiac troponin T, testicular alfa-fetoprotein and other biomarkers in rats
dc.typejournal-article
oaire.citation.volume267

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