Browsing by Author "Oyerinde, A.A."
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Item Antiproliferative and Antimicrobial Activities of Citrus limon (L.) Burm. f. Stem Bark Extract(Nigerian Journal of Basic and Applied Science, 2021) Salawu, K.M.; Oyerinde, A.A.; Bello, R.H.Citrus limon is traditionally use for the treatment of several ailments including infectious diseases. This study was designed to evaluate antiproliferative and antimicrobial activities of Citrus limon stem bark extract. The plant material was collected, authenticated, air-dried and pulverized. Two hundred grams of powdered plant material was extracted into distilled methanol by cold maceration and the extract was concentration in a vacuo. The extract was subjected to in vitro phytochemical screening and bioassays including; antiproliferative assay (Sorghum bicolor radicle and Allium cepa root growth inhibitory assays) and antimicrobial susceptibility against Escherichia coli, Staphylococcus aureus, Citrobacter ferundii and Candida albicans. Phytochemical evaluation detected the presence of alkaloids, flavonoids and cardiac glycoside in the extract. The extract displayed concentration-dependent antiproliferative activity with an IC50 of 1.10±0.07 and 0.62±0.04 mg/mL compared to cyclophosphamide (IC50 of 0.17±0.02 and 0.83±0.08 mg/mL) for Sorghum bicolor radical growth and Allium cepa root growth inhibitory assays, respectively. The extract displayed antimicrobial activity with the highest activity against Escherichia coli and Citrobacter ferundii with activity indices of 0.68 and 0.59, respectively compared to gentamicin. Citrus limon stem bark extract displayed antiproliferative and antimicrobial activities.Item Growth inhibitory properties and antimicrobial evaluation of Aloe schweinfurthii (Baker) leaf rind extract(African Journals Online, 2020) Salawu, K.M.; Oyerinde, A.A.; Aliyu, A.; Obajemihi O. ICancer and infectious diseases combined are leading cause of death and public health concern. In developing countries, about 80% of the populace depends on medicinal plants for their general health care needs including treatment of infectious diseases and cancer. Aloe schweinfurthii (Aloaceae) is a small medicinal herb that is commonly used for the treatment of cancerous and infectious diseases in South-West Nigeria. The focus of this study was to evaluate the growth inhibitory and antimicrobial activities of the herb. The rind of the herb was collected, air dried, pulverized and extracted into distilled methanol by cold maceration. The dried extract obtained was subjected to growth inhibitory and antimicrobial assays. The extract displayed concentration dependent growth inhibitory activity with IC50 of 484.7±2.16 and 1188±2.32µg/mL compared to cyclophosphamide with IC50 of 174.3±0.19 and 834.5±0.84 µg/mL in Sorghum bicolor radical and Allium cepa root growth inhibitory assays, respectively. The extract displayed concentration dependent antibacterial and antifungal effects with the highest activity against C. freundi (18 mm zone of inhibition) at 50 mg/mL. The extract of Aloe schweinfurthii leaf rind displayed marked growth inhibitory and antimicrobial bioactivities. The extract maybe considered as a viable candidate for discovery of chemotherapeutic agent (s).Item Growth Inhibitory Properties and Antimicrobial Evaluation of Aloe schweinfurthii (Baker)(Journal of Pharmacy and Bioresources, 2020) Salawu, K.M.; Oyerinde, A.A.; Aliyu, A.; Obajemihi, O.I.Cancer and infectious diseases combined are leading cause of death and public health concern. In developing countries, about 80% of the populace depends on medicinal plants for their general health care needs including treatment of infectious diseases and cancer. Aloe schweinfurthii (Aloaceae) is a small medicinal herb that is commonly used for the treatment of cancerous and infectious diseases in South-West Nigeria. The focus of this study was to evaluate the growth inhibitory and antimicrobial activities of the herb. The rind of the herb was collected, air dried, pulverized and extracted into distilled methanol by cold maceration. The dried extract obtained was subjected to growth inhibitory and antimicrobial assays. The extract displayed concentration dependent growth inhibitory activity with IC50 of 484.7±2.16 and 1188±2.32µg/mL compared to cyclophosphamide with IC50 of 174.3±0.19 and 834.5±0.84 µg/mL in Sorghum bicolor radical and Allium cepa root growth inhibitory assays, respectively. The extract displayed concentration dependent antibacterial and antifungal effects with the highest activity against C. freundi (18 mm zone of inhibition) at 50 mg/mL. The extract of Aloe schweinfurthii leaf rind displayed marked growth inhibitory and antimicrobial bioactivities. The extract maybe considered as a viable candidate for discovery of chemotherapeutic agent (s).Item Phytochemical, Antioxidant, Cytotoxicity, Antiproliferative and Antimicrobial Studies of Securinega Virosa Aerial Parts Extract(Journal of Pharmaceutical and Allied Sciences, 2020) Salawu, K.M.; Oyerinde, A.A.; Ajaiyeoba, E.O.Cancer and infectious diseases are leading causes of death, globally. Securinega virosa is locally used for the manage ent of cancerous tumour and infectious diseases. This study was designed to investigate the phytochemical consituents of the plant’s aerial parts and determine the antioxidant, antiproliferative and cytotoxic properties of theextract using standard laboratory procedures. The plant was collected and the aerial parts was extracted with methanol. The extract was found to contain alkaloids, flavonoids, tannins, saponins and cardiac glycosides. It displayed potent antioxidant activity with an IC50 of 0.018±0.002 mg/mL compared to ascorbic acid (0.008±0.001 mg/mL) and was nontoxic to brine shrimp. The extract displayed potent antiproliferative activity with an IC50 value of 1.50±0.037 mg/mL compared to the value for cyclophosphamide, 0.55±0.043 mg/mL in Allium cepa root growth inhibitory assay. The extract displayed potent activities (IC50 = 11.31±0.18 and 7.23±0.01 μg/mL) on RD and Hep-2C cancer cells, respectively, compared to cyclophosphamide (IC50 = 0.32±0.18 and 2.56±0.13 μg/mL). The extract also displayed some antibacterial and anti-fungi activities with up to 10 and 14 mm zones of inhibition against Escherichia coli, Citrobacter ferundii at 0.625 mg/disc, respectively. Securinega virosa extract displayed antioxidant, antiproliferative, cytotoxic and antimicrobial activities and the plant maybe considered a viable candidate for discovery of chemotherapeutic agent(s)