Growth inhibitory properties and antimicrobial evaluation of Aloe schweinfurthii (Baker) leaf rind extract
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
African Journals Online
Abstract
Cancer and infectious diseases combined are leading cause of death and public health concern. In developing
countries, about 80% of the populace depends on medicinal plants for their general health care needs including
treatment of infectious diseases and cancer. Aloe schweinfurthii (Aloaceae) is a small medicinal herb that is commonly
used for the treatment of cancerous and infectious diseases in South-West Nigeria. The focus of this study was to
evaluate the growth inhibitory and antimicrobial activities of the herb. The rind of the herb was collected, air dried,
pulverized and extracted into distilled methanol by cold maceration. The dried extract obtained was subjected to
growth inhibitory and antimicrobial assays. The extract displayed concentration dependent growth inhibitory activity
with IC50 of 484.7±2.16 and 1188±2.32µg/mL compared to cyclophosphamide with IC50 of 174.3±0.19 and
834.5±0.84 µg/mL in Sorghum bicolor radical and Allium cepa root growth inhibitory assays, respectively. The extract
displayed concentration dependent antibacterial and antifungal effects with the highest activity against C. freundi (18
mm zone of inhibition) at 50 mg/mL. The extract of Aloe schweinfurthii leaf rind displayed marked growth inhibitory
and antimicrobial bioactivities. The extract maybe considered as a viable candidate for discovery of chemotherapeutic
agent (s).
Description
Keywords
Growth inhibition, Antimicrobial, Aloe schweinfurthii, Chemotherapeutic Agent
Citation
Salawu, K.M., Oyerinde, A.A., Aliyu, A. & Obajemihi O. I. (2020). Growth inhibitory properties and antimicrobial evaluation of Aloe schweinfurthii (Baker) leaf rind extract J. Pharmacy & Bioresources 17(2), 174-179. https://www.ajol.info/index.php/jpb/article/view/205680