Growth inhibitory properties and antimicrobial evaluation of Aloe schweinfurthii (Baker) leaf rind extract

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dc.contributor.authorSalawu, K.M.
dc.contributor.authorOyerinde, A.A.
dc.contributor.authorAliyu, A.
dc.contributor.authorObajemihi O. I
dc.date.accessioned2024-05-13T08:30:34Z
dc.date.available2024-05-13T08:30:34Z
dc.date.issued2020
dc.description.abstractCancer and infectious diseases combined are leading cause of death and public health concern. In developing countries, about 80% of the populace depends on medicinal plants for their general health care needs including treatment of infectious diseases and cancer. Aloe schweinfurthii (Aloaceae) is a small medicinal herb that is commonly used for the treatment of cancerous and infectious diseases in South-West Nigeria. The focus of this study was to evaluate the growth inhibitory and antimicrobial activities of the herb. The rind of the herb was collected, air dried, pulverized and extracted into distilled methanol by cold maceration. The dried extract obtained was subjected to growth inhibitory and antimicrobial assays. The extract displayed concentration dependent growth inhibitory activity with IC50 of 484.7±2.16 and 1188±2.32µg/mL compared to cyclophosphamide with IC50 of 174.3±0.19 and 834.5±0.84 µg/mL in Sorghum bicolor radical and Allium cepa root growth inhibitory assays, respectively. The extract displayed concentration dependent antibacterial and antifungal effects with the highest activity against C. freundi (18 mm zone of inhibition) at 50 mg/mL. The extract of Aloe schweinfurthii leaf rind displayed marked growth inhibitory and antimicrobial bioactivities. The extract maybe considered as a viable candidate for discovery of chemotherapeutic agent (s).
dc.identifier.citationSalawu, K.M., Oyerinde, A.A., Aliyu, A. & Obajemihi O. I. (2020). Growth inhibitory properties and antimicrobial evaluation of Aloe schweinfurthii (Baker) leaf rind extract J. Pharmacy & Bioresources 17(2), 174-179. https://www.ajol.info/index.php/jpb/article/view/205680
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/14099
dc.publisherAfrican Journals Online
dc.subjectGrowth inhibition
dc.subjectAntimicrobial
dc.subjectAloe schweinfurthii
dc.subjectChemotherapeutic Agent
dc.titleGrowth inhibitory properties and antimicrobial evaluation of Aloe schweinfurthii (Baker) leaf rind extract
dc.title.alternativeKayode Muritala SALAWU
dc.title.alternativeAbdulsalam Ayodeji OYERINDE
dc.title.alternativeAbdulmalik ALIYU
dc.title.alternativeObafemi Ibitayo OBAJEMIHI

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