Browsing by Author "Olayaki, L.A.,"

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    Correlation between testosterone and prostate specific antigen in male baldness in (Government Specialist Hospital, Sobi) Ilorin West, Local Government Area, Kwara State, Nigeria
    (Faculty of Basic Medical Sciences, Lagos State University College of Medicine, 2017) Ojulari, L.S.,; Ayinde, T.O.,; Sanni, M.,; Olayaki, L.A.,; Quadri, K.,; Egbeche, E.; Dangana, E.O.
    Background: Male pattern hair loss (MPHL) is influenced by increased androgenic activities in the body, prostatic diseases has been linked with high androgenic activities, especially Dihydrotestosterone (DHT) that influences the growth of hair on the body and prostatic cells. This study aimed to check the relationship between androgenic activity with respect to prostatic specific antigen (PSA) expression in bald and non-bald men. Methods: Seventy (70) subjects participated in this study at the Kwara State Specialist Hospital, Ilorin. These subjects were divided into two equal groups of 35 subjects each. Group A- served as control subject; men with no apparent baldness while group B- comprised of men with apparent baldness. A questionnaire was given to each subject to ensure participation was voluntary. Blood sample was collected from each subject to be used for hormonal assay to check for PSAand TTconcentrations using appropriate kits. Results: Plasma testosterone significantly increased in men with apparent baldness (P≤0.001) compared to control subjects. PSA also increased insignificantly in men with apparent baldness which might be indicative of probable occurrence of prostate carcinoma or hyperplasia in men with apparent baldness. Conclusion: This study revealed that prostate carcinoma might occur in male with apparent baldness due to progressive increase in PSA along with increased androgenic activity
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    Effect of Chronic Administration of Medroxylprogesterone (Depo-Provera) Contraceptive on Renal Function in Female Wistar Rats.
    (Association of Specialist Medical Doctors in Academics, 2022) Ayinde, T.O.,; Ojulari, LS.,; Faramade, A.A.,; Amali, M.O.,; Olayaki, L.A.,; Ajao, M.S
    Background: Medroxyprogesterone (Depo-Provera) is an injectable contraceptive used in preventing ovulation, and thus pregnancy. Progesterone used in oral contraceptives has been implicated in some renal diseases. Thus, Depo-Provera which is a form of progesterone that is associated with some adverse effects must be cautiously used. The study was carried out to investigate the effect of chronic administration of Depo-Provera on renal functions in female Wistar rats. Methodology: Twenty-four female Wistar rats were randomly grouped into four groups of 6 rats each with group I as control. Group II was administered 2.14mg/kg (low dose), group III was administered 4.28mg/kg (moderate dose), and group IV was administered 8.56mg/kg (high dose) of Depo-Provera once. Weekly urine analysis was done throughout the three months of the study, following which the rats were euthanized, and blood samples collected for serum electrolytes, urea and creatinine. Result: The moderate and high dose groups showed significant (p<0.05) decrease in calcium, and significant (p<0.05) increase in potassium, urea and creatinine levels. There was also significant (p<0.05) decrease in sodium of high dose, and significant (p<0.05) increase in creatinine of low dose groups; however, there was no significant (p>0.05) change in serum phosphate and chloride levels globally. The urinalysis results summarily showed protein was positive (+) with a pH of 5.5 in low dose group, while the moderate and high dose groups were positive for bilirubin (2+), and protein (3+) with a pH of 4.0. Conclusion: Depo-Provera should be cautiously used to avoid renal dysfunction due to accumulation of urea and creatinine, and loss of bone mineral density which can predispose to osteoporosis. Keywords: Creatinine, Medroxyprogesterone, Renal functions, Serum electrolytes
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    Effect of jatropha curcas seed aqueous extract on quality of semen and reproductive hormones in male Wistar rats
    (Society of Basic and Applied Physiology, 2022) Ayinde, T.O.,; Abubakar, H.O.,; Ojulari, L.S.,; Balogun, M.E.,; Liadi, M.T.,; Olayaki, L.A.,; Belewu, M.A.,; Afodun, A.M
    Background: Jatropha curcas is gaining popularity in recent times due to its medicinal value but with less regards to its adverse health effect especially as it concerns male infertility. The current study was aimed at investigating the effect of Jatropha curcas seed extract on quality of semen and reproductive hormones in male Wistar rats. Methodology: Twenty-four male Wistar rats were randomly divided into four groups of six rats each. Group I served as control and was given 0.9% normal saline, while groups II, III and IV were administered 100, 200 and 400mg/kg of the extracts respectively for 60 days. The rats were then euthanised and blood samples collected via cardiac puncture for testosterone, LH and FSH assay; and semen collected for seminal fluid analysis. Results: There was significant (p<0.05) decrease in sperm count, significant (p<0.05) increase in total sperm abnormality, and significant (p<0.05) increase in sperm motility only at high dose when compared with the control. There was also significant (p<0.05) reduction in testosterone and FSH, while LH showed significant (p<0.05) increase. Conclusion: Jatropha curcas seed extract severed sperm quality with affectation of male reproductive hormones. Thus, male desirous of having babies should exercise caution in its patronage.
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    Hepatoprotective Effect of Tryptophan in Carbontetrachloride-Induced Hepatotoxicity in Male Wistar Rats.
    (Society of Basic and Applied Physiology, 2021) Ayinde, T.O.,; Olayaki, L.A.,; Ojulari, L.S.,; Oluwasola, A.,; Abdulraheem, H.A.,; Lawal, A.Z.,; Alli-Oluwafuyi, A.
    In the present study, tryptophan was evaluated for its hepatoprotective effects against carbontetrachloride-induced hepatocellular injury in rats. Hepatotoxicity was induced in male SpragueDawley rats by intraperitoneal injection of CCl4 (4ml/kg) in olive oil (1:1). Tryptophan at doses of 100mg/kg and 200mg/kg was administered orally for 28 days. The hepatoprotective effect of tryptophan was evaluated by the assay of biochemical parameters viz.: alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), alkaline phosphatase (ALP), total protein, albumin and lipid peroxidation. Tryptophan produced a dose-dependent significant increase (p<0.001) in serum ALP (41% & 60%), a dose-dependent decrease (p<0.001) in serum Malondialdehyde (61% & 65%), and a significant increase (p<0.001) in levels of serum protein and serum albumin, in CCl4induced hepatotoxic rats, following administration of 100 mg/kg bwand 200 mg/kg bw, respectively. The toxic effect of CCl4 in tryptophan treated groups was controlled significantly by restoration of the levels of enzymes, total protein and albumin as compared to the CCl4 treated groups. The results suggest that tryptophan is able to significantly alleviate the hepatotoxicity induced by CCl4 and may be attributed to the antioxidant property of tryptophan.