Correlation between testosterone and prostate specific antigen in male baldness in (Government Specialist Hospital, Sobi) Ilorin West, Local Government Area, Kwara State, Nigeria
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Date
2017
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Journal ISSN
Volume Title
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Faculty of Basic Medical Sciences, Lagos State University College of Medicine
Abstract
Background: Male pattern hair loss (MPHL) is influenced by increased androgenic activities in the body,
prostatic diseases has been linked with high androgenic activities, especially Dihydrotestosterone (DHT)
that influences the growth of hair on the body and prostatic cells. This study aimed to check the relationship
between androgenic activity with respect to prostatic specific antigen (PSA) expression in bald and non-bald
men.
Methods: Seventy (70) subjects participated in this study at the Kwara State Specialist Hospital, Ilorin.
These subjects were divided into two equal groups of 35 subjects each. Group A- served as control subject;
men with no apparent baldness while group B- comprised of men with apparent baldness. A questionnaire
was given to each subject to ensure participation was voluntary. Blood sample was collected from each
subject to be used for hormonal assay to check for PSAand TTconcentrations using appropriate kits.
Results: Plasma testosterone significantly increased in men with apparent baldness (P≤0.001) compared to
control subjects. PSA also increased insignificantly in men with apparent baldness which might be
indicative of probable occurrence of prostate carcinoma or hyperplasia in men with apparent baldness.
Conclusion: This study revealed that prostate carcinoma might occur in male with apparent baldness due to
progressive increase in PSA along with increased androgenic activity
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Keywords
Citation
Dihydrotestoster one, Male Pattern Baldness, Prostatic Specific Antigen.