Effect of Chronic Administration of Medroxylprogesterone (Depo-Provera) Contraceptive on Renal Function in Female Wistar Rats.
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Date
2022
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Association of Specialist Medical Doctors in Academics
Abstract
Background: Medroxyprogesterone (Depo-Provera) is an injectable
contraceptive used in preventing ovulation, and thus pregnancy.
Progesterone used in oral contraceptives has been implicated in some
renal diseases. Thus, Depo-Provera which is a form of progesterone that
is associated with some adverse effects must be cautiously used. The
study was carried out to investigate the effect of chronic administration
of Depo-Provera on renal functions in female Wistar rats.
Methodology: Twenty-four female Wistar rats were randomly grouped
into four groups of 6 rats each with group I as control. Group II was
administered 2.14mg/kg (low dose), group III was administered
4.28mg/kg (moderate dose), and group IV was administered 8.56mg/kg
(high dose) of Depo-Provera once. Weekly urine analysis was done
throughout the three months of the study, following which the rats were
euthanized, and blood samples collected for serum electrolytes, urea and
creatinine.
Result: The moderate and high dose groups showed significant (p<0.05)
decrease in calcium, and significant (p<0.05) increase in potassium, urea
and creatinine levels. There was also significant (p<0.05) decrease in
sodium of high dose, and significant (p<0.05) increase in creatinine of
low dose groups; however, there was no significant (p>0.05) change in
serum phosphate and chloride levels globally. The urinalysis results
summarily showed protein was positive (+) with a pH of 5.5 in low dose
group, while the moderate and high dose groups were positive for
bilirubin (2+), and protein (3+) with a pH of 4.0.
Conclusion: Depo-Provera should be cautiously used to avoid renal
dysfunction due to accumulation of urea and creatinine, and loss of bone
mineral density which can predispose to osteoporosis.
Keywords: Creatinine, Medroxyprogesterone, Renal functions, Serum
electrolytes
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Creatinine, Medroxyprogesterone, Renal functions, Serum electrolytes