Effect of Chronic Administration of Medroxylprogesterone (Depo-Provera) Contraceptive on Renal Function in Female Wistar Rats.
| dc.contributor.author | Ayinde, T.O., | |
| dc.contributor.author | Ojulari, LS., | |
| dc.contributor.author | Faramade, A.A., | |
| dc.contributor.author | Amali, M.O., | |
| dc.contributor.author | Olayaki, L.A., | |
| dc.contributor.author | Ajao, M.S | |
| dc.date.accessioned | 2024-04-23T14:22:36Z | |
| dc.date.available | 2024-04-23T14:22:36Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Background: Medroxyprogesterone (Depo-Provera) is an injectable contraceptive used in preventing ovulation, and thus pregnancy. Progesterone used in oral contraceptives has been implicated in some renal diseases. Thus, Depo-Provera which is a form of progesterone that is associated with some adverse effects must be cautiously used. The study was carried out to investigate the effect of chronic administration of Depo-Provera on renal functions in female Wistar rats. Methodology: Twenty-four female Wistar rats were randomly grouped into four groups of 6 rats each with group I as control. Group II was administered 2.14mg/kg (low dose), group III was administered 4.28mg/kg (moderate dose), and group IV was administered 8.56mg/kg (high dose) of Depo-Provera once. Weekly urine analysis was done throughout the three months of the study, following which the rats were euthanized, and blood samples collected for serum electrolytes, urea and creatinine. Result: The moderate and high dose groups showed significant (p<0.05) decrease in calcium, and significant (p<0.05) increase in potassium, urea and creatinine levels. There was also significant (p<0.05) decrease in sodium of high dose, and significant (p<0.05) increase in creatinine of low dose groups; however, there was no significant (p>0.05) change in serum phosphate and chloride levels globally. The urinalysis results summarily showed protein was positive (+) with a pH of 5.5 in low dose group, while the moderate and high dose groups were positive for bilirubin (2+), and protein (3+) with a pH of 4.0. Conclusion: Depo-Provera should be cautiously used to avoid renal dysfunction due to accumulation of urea and creatinine, and loss of bone mineral density which can predispose to osteoporosis. Keywords: Creatinine, Medroxyprogesterone, Renal functions, Serum electrolytes | |
| dc.identifier.citation | Creatinine, Medroxyprogesterone, Renal functions, Serum electrolytes | |
| dc.identifier.issn | Print: 2811-1672 Online: 2811-1680 | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/123456789/12664 | |
| dc.language.iso | en | |
| dc.publisher | Association of Specialist Medical Doctors in Academics | |
| dc.relation.ispartofseries | 2 (1); ; 48-50 | |
| dc.title | Effect of Chronic Administration of Medroxylprogesterone (Depo-Provera) Contraceptive on Renal Function in Female Wistar Rats. | |
| dc.type | Article |