Browsing by Author "Olawumi, H.O"
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Item The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria(Hindawi Publishing Corporation, 2015) Sani, M.A.; Adewuyi, J.O.; Babatunde, A.S; Olawumi, H.O; Shittu, R.O.Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in theworld. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic systemic organ damage. Recent studies have suggested that individuals with SCA especially from developing countries are more likely to be iron deficient rather than have iron overload. The study aims to determine the iron status of SCA patients in Ilorin, Nigeria. Methods. A cross-sectional study of 45 SCA patients in steady state and 45 non- SCA controls was undertaken. FBC, blood film, sFC, sTfR, and sTfR/log sFC index were done on all subjects. Results. The mean patients’ serum ferritin (589.33 ± 427.61 ng/mL) was significantly higher than the mean serum ferritin of the controls (184.53 ± 119.74 ng/mL).Themean serum transferrin receptor of the patients (4.24 ± 0.17 𝜇g/mL) was higher than that of the controls (3.96 ± 0.17 𝜇g/mL) (𝑝 = 0.290). The mean serum transferrin receptor (sTfR)/log serum ferritin index of the patients (1.65 ± 0.27 𝜇g/mL) was significantly lower than that of the control (1.82 ± 0.18 𝜇g/mL) (𝑝 = 0.031). Conclusion. Iron deficiency is uncommon in SCA patients and periodic monitoring of the haematological, biochemical, and clinical features for iron status in SCA patients is advised.Item Normal CD4 Count Range among Healthy Nigerian Population in Ilorin(2014) Afolabi, J.K.; Fadeyi, A; Desalu, O O.; Durotoye, I. A; Fawibe, A. E.; Adeboye, M.A.N; Olawumi, H.O; Babatunde, A.S; Ernest, S.K; Aderibigbe, S.A; Saadu, R; Salami, A.K; Aboyeji, A.PBackground: For the establishment and monitoring of the immune status, CD4 count is critical. Objectives: To determine the CD4 count range of apparently healthy Nigerians resident in Ilorin and compare with the national value. Methods: An automated blood analyzer was used to determine the full blood count and CD4 count. The percentage of CD4 count was derived by using other variables. Results: Of the 1205 participants, the reference CD4 count (percentage of CD4) range for adult was 400 to 1288 cells/mm3 (19%-48%) and for children was 582 to 3652 cells/mm3 (17%-50%). CD4 count and percentage of CD4 were significantly (P ¼ .001) higher in females than in males, and the CD4 count declined significantly with increasing age (r ¼ .174, P .0001). The percentage of CD4 count shows less variation with age (r ¼ .051, P ¼ .076). Adult residents of Ilorin had significantly lower absolute mean CD4 count (808 + 260) than that of the national reference values of 847.0 + 307.0 cells/mm3 (P ¼ .001). Conclusion: We therefore advocate the use of CD4 count range derived in this study is lower than that of the national reference values.Item Reference Values of Haematological Parameters of Healthy Adults in the North Central Zone of Nigeria(Kenya Medical Association, 2015) Olawumi, H.O; Durotoye, I. A.,; Afolabi, J. K.; Fadeyi, A.,; Desalu, O.O.,; Aderbigbe, S.A.,; Babatunde, A.S.,; Ernest, S.K.,; Fawibe, A.E.,; Salami, A.K.,; Saadu, R.,; Adeboye, M.A.N.,; Aboyeji, A.P.Background: Haematological parameters differ from one population to another due to several factors. To determine the clinical implication of the blood parameters of an individual in the state of health or disease, we need to have the knowledge of the normal reference range for that locality. Objectives: To determine the reference values of haematological parameters of apparently healthy adults in Ilorin. Design: A descriptive cross sectional study. Setting: Ilorin, North Central zone of Nigeria Subjects: Nine hundred and ten (443 males and 467 females) randomly selected normal, HIV negative individuals aged 18-65 years Results: The red blood cell count, Haemoglobin concentration, PCV and MCHC were significantly higher among males than females while the platelet count, total WBC count and absolute neutrophil count were significantly higher in females than in males. There was however no significant gender difference in the values of MCV, MCH and absolute lymphocyte count. The normal reference values obtained in this study were notably different from those that are used currently in the hospital. Conclusion: The normal reference value obtained in this study was notable different from those that are currently used in the hospital. These findings will have clinical implications regarding the adjustment of our current reference values and definitely add value to the management of patients in this part of the country. INTRODUCTION A full blood count is one of the most frequently requested investigations for routine medical checkup and preliminary investigation in the diagnosis of many diseases in every field of Medicine. It is also a common investigation used to monitor the treatment of several diseases especially in patients on cytotoxic drugs (1). The parameters in a full blood count also known as haematological parameters are affected by many different factors such as age, gender, race, altitude, exercise, pregnancy