Browsing by Author "Olawumi, H. O."

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    Determination of Haemoglobin Concentration of Prospective Voluntary Blood Donors using Digital Haemoglobinometer in North Central Nigeria
    (College of Health Sciences, Ambrose Alli University, Ekpoma, 2020-06) Durotoye, I.A.; Salaudeen, A. G.; Babatunde, A. S.; Durowade, K. A.; Sanni, E. O; Akande, T. M.; Olawumi, H. O.; Musa, O. I.
    Haemoglobin estimation is one of the most important criteria in donor selection so as to safeguard the health of donors. To achieve this, reliable and cost-effective methods should be employed during blood donation drive. The aim of this study was to determine the haemoglobin concentration of voluntaryblood donors using digital haemoglobinometer. This study was a prospective, community based conducted in five tertiary institutions in Kwara and Kogi States. Blood samples were taking from consecutive male and female donors within the age of 15-63 years following blood donation campaign. Assessment of haemoglobin concentration was done using Diaspect haemoglobinometer. A total of 905 students and staff of five tertiary institutions participated in this study. The mean age of the respondents was 21.98±5.17 years and 96.3% were below 30 years of age. The mean, median, and standard deviation of heamoglobin level were 13.22, 13.20, and 1.62 g/dl respectively. Using the WHO haemoglobin cut –off value of 12.5g/dl for donor selection, about 64.1% of the prospective donor had haemoglobin value of greater. There was a statistically significant difference between haemoglobin level of male and female donors (p=0.001). This study revealed that 64% of blood donors had heamoglobin concentration greater than 12.5g/dl and were fit for blood donation. Students of tertiary institutions could therefore be encouraged for regular blood donation to meet WHO vision 2020 towards attaining 100% voluntary non-remunerated blood donors
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    Determination of Normal and Variant Hemoglobin using Capillary Electrophoresis among Voluntary Blood Donors in North Central Nigeria: Implications on Blood Transfusion Services
    (Faculty of Medicine and Health Sciences - Omdurman Islamic University, 2021) Durotoye, I. A.; Salaudeen, A. G.; Sanni, E. O.; Babatunde, A. S.; Durowade, A. K.; Olawumi, H. O.; Akande, T. M.; Musa, O. I.
    Abstract Background: Voluntary non-remunerated blood donation is a strategy adopted by World Health Organization aimed at ensuring safety and adequacy of blood supply. Sub-Saharan Africa has a high prevalence of hemoglobin disorders and therefore needs to adopt stringent measures in donor selection to ensure safety for the recipient of blood transfusion. This study aimed to analyze normal and variant hemoglobin among voluntary blood donors. Methods: In this descriptive cross-sectional study, 100 prospective blood donors including 55 (55%) males and 45 (45%) females, aged 18–34 years were recruited. Capillary electrophoresis using the Minicap system was used for determining the hemoglobin variants in alkaline buffer (PH 9.4). Data analysis was done using SPSS version 20 and p-value < 0.05 was considered as the level of significance Results: The mean age of the participants was 22.23 ± 3.3 SD years. The proportion of participants with genotype AA was 67 (67%), those with AS were 17 (22 %), while those with AC were 11 (11 %). While Hb A ≥ 90% was noted in 67 (67%) blood donors, Hb S was seen in 22 (22%) and Hb A2 > 3.5% in 57 (57%). Hb F > 2% was observed in 3% of the studied participants Conclusion: Variant hemoglobin is common among blood donors and this should be taken into consideration whenever blood is being crossmatched for recipients of blood transfusion. Data from this study will be useful in raising awareness and genetic counseling.
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    Haemostatic Parameters during Pregnancy in Ilorin, Nigeria
    (College of Health Sciences, University of Ilorin, 2012) Durotoye, I. A.; Babatunde, A.S.; Olawumi, H. O.; Olatunji, P. O.; Adewuyi, J. O.
    Abstract The objective of this study was to document the effect of pregnancy on some haemostatic parameters (Prothrombin time [PT], activated partial thromboplastin time [APTT], fibrinogen concentration, euglobin clot lysis time [ELT], and platelet count) in different trimesters of pregnancy. One hundred and eighty women with non-complicated pregnancy within the age range of 17-40 years (mean± SD 27.1±3.9years) were recruited for the study and sixty non-pregnant, normotensive apparently healthy age-matched women were used as control. All haemostatic parameters evaluated were determined using standard techniques. Significant differences were observed between the haemostatic parameters studied and controls except for platelet count. Prothrombin time was significantly shorter (p<0.001) and fibrinogen significantly higher (p<0.001) as pregnancy advanced but, other parameters were not influenced by the gestational age. There was a significant difference between the fibrinogen level in older subject compared with subject of younger age group with a mean of 5.5g/l and 4.0g/l (p<0.05) respectively. There was no significant relationship in the haemostatic parameters with parity and educational level of all the subjects. In conclusion, the results of haemostatic screening tests in this study suggest some degree of activation in pregnant women.
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    Normal CD4+ Cell Count Range Amongst Healthy Nigerian Population In Ilorin,
    (International Association of Providers of AIDS Care., 2014) Afolabi, J. K.; Fadeyi, A; Desalu, O. O.; Durotoye, I. A.; Fawibe, A. E.; Adeboye, M. A. N.; Olawumi, H. O.; Babatunde, A. S.; Ernest, S. K.; Aderibigbe, S. A.; Saadu, R.; Salami, A. K.; Aboyeji, A. P.
    Background: For the establishment and monitoring of the immune status, CD4 count is critical. Objectives: To determine the CD4 count range of apparently healthy Nigerians resident in Ilorin and compare with the national value. Methods: An automated blood analyzer was used to determine the full blood count and CD4 count. The percentage of CD4 count was derived by using other variables. Results: Of the 1205 participants, the reference CD4 count (percentage of CD4) range for adult was 400 to 1288 cells/mm 3 (19%-48%) and for children was 582 to 3652 cells/mm 3 (17%-50%). CD4 count and percentage of CD4 were significantly (P 1⁄4 .001) higher in females than in males, and the CD4 count declined significantly with increasing age (r 1⁄4 .174, P .0001). The percentage of CD4 count shows less variation with age (r 1⁄4 .051, P 1⁄4 .076). Adult residents of Ilorin had significantly lower absolute mean CD4 count (808 + 260) than that of the national reference values of 847.0 + 307.0 cells/mm 3 (P 1⁄4 .001). Conclusion: We therefore advocate the use of CD4 count range derived in this study is lower than that of the national reference values.