Browsing by Author "Ojulari, L. S."

Now showing 1 - 9 of 9
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    ABO/Rhesus blood group systems are not clinical indicators of male baldness
    (College of Medicine, Ambrose Alli University, Edo, Nigeria, 2017-06) Ayinde, T. O.; Ojulari, L. S.; Sanni, M. A.; Afodun, A. M.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Ayinla, M. T.; Abdulazeez, F. I.; Abdulkareem, S.; Abdulraheem, H. A.; Samotu, K.
    Background: Several disease entities have been linked to the ABO/Rh blood group systems.Baldness or alopecia is the partial or complete lack of hair on the head and/or body. Major advances have been achieved in understanding principal elements of the androgen metabolism involved in the pathogenesis of alopecia, but not much preliminary work has been done in its relationship to blood types. Aim: This study is aimed to determine if there is any association between blood types and male baldness. Methods: 400 male subjects (25-60 years)at Sobi Specialist Hospital Alagbado, Ilorin, kwara State, Nigeria were recruited into the study(200 for control and 200 for baldness).Blood sample was collected from each subject for blood grouping estimation, following the completion of a questionnaire containing information about baldness and haematological profile. Result: The distribution of phenotypic frequencies of ABO group in the control samples were 26.0%, 28.0%, 4.0% and 42.0% for groups A, B, AB and O, respectively, while 92.0% of the subjects were Rh (D) positive and 8.0% Rh(d) negative. And for the baldness, they were 26.0%, 26.0%, 4.0% and 44% for A, B, AB, and O respectively; while Rh (D) positive were 94.0% and Rh (d) negative were 6.0%. The overall result is statistically insignificant (P>0.05) using Pearson Chi-square. Conclusion: The result reflects an absolute parallel relationship between baldness and ABO/Rhesus blood group systems. Thus, ordering for blood group assessment during routine hair clinic as part of ancillary investigation should be discouraged, except if other interests arise.
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    Anacardium occidentale and Psidium guajava effectively reduce ethanol-induced gastric ulcer in male Wistar rats
    (Published by University of Ilorin, Ilorin, Nigeria, 2016) Oyabambi, A. O.; Oyeniyi, P. O.; Ojulari, L. S.; Oladoye, O. D.
    Ulcer is one of the world’s major gastrointestinal disorders affecting a good percentage of the populace in industrialised and developing countries. Plant extracts are some of the most attractive sources of new drugs and have shown promising results for the treatment of gastric ulcer as they possess a variety of natural therapeutic products. This study aimed to look at the effect of combining Anacardium occidentale and Psidium guajava on the management of gastric ulcer. The extracts of the leaves of Anacardium occidentale and Psidium guajava were tested in ethanol-induced ulcer models in rats. Oral administration of these plant extracts and reference drug was done for two weeks for 30 male Wistar rats divided into five (5) groups. The treatment with the combination of the extracts stock solutions at a dose of 150 mg/kg each exhibited a significant (p < 0.05) decrease in gastric volume, 2.1×10⁷ mEq/L, and ulceration, 2.0±0.26 than the individual extract groups when compared to control 4.0×10⁷ mEq/L and 5.2±0.60 respectively, while cimetidine at the dose tested had the highest percentage reduction. The efficacy of the extracts presented here confirms that the combination of Anacardium occidentale and Psidium guajava possess better synergistic ulcer healing and gastric protective effects than the individual components. This affirms their efficacy in the management of ulcers.
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    Aqueous extract of Carica papaya leaves improves hyperglycemia, hyperalgesia, and oxidative stress in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
    (Biomedical Communications Group, Ibadan, Nigeria, 2022-10) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Akintoye, O. O.; Ajibare, A. J.; Jimoh, O. S.; Owoyemi, J. O.; Ananias, E. N.; Ibiyeye, V. O.; Aboyeji, A. M.; Ojulari, L. S.
    Aqueous extract of Carica papaya leaves was investigated for its acclaimed neuroprotective activity in streptozotocin-induced diabetic peripheral neuropathy in rats. Twenty male, Wistar rats weighing between 120 & 170g were randomly assigned into four groups of five animals each. Rats in group 1 were normal, healthy rats that received normal saline 1.0ml/kg b. w. Those in group 2 (diabetic untreated) received normal saline 1.0ml/kg b. w., group 3 was treated with pregabalin 0.71mg/kg b. w. and group 4 received the aqueous leaf extract of Carica papaya 200mg/kg b. w. Plasma glucose concentration, thermal and mechanical allodynia, and biochemical biomarkers in the brain [malondialdehyde (MDA) and nitric oxide (NO)]; nerve [brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)]; and serum [superoxide dismutase (SOD) and glutathione (GSH)] were assessed. The results showed that the Carica papaya leaf-treated (group 4) rats had a significant fall in the plasma glucose level (p˂0.0001); higher pain threshold on ice cold and von Frey tests (p<0.0001); lower MDA and higher NO, BDNF, NGF, SOD and GSH levels compared to diabetic untreated (p<0.0001) and pregabalin-treated (p<0.0001) rats. Carica papaya leaf extract reduces plasma glucose, mechanical and thermal hyperalgesia, oxidative stress, and nerve damage in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
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    Association between handgrip strength and insulin sensitivity and beta-cell function in non-diabetic, young, Nigerian adults
    (The National Institute for Medical Research in Tanzania., 2025-01) Ojulari, L. S.; Kolawole P. O.; Aliyu, A.; Yusuf, H. O.; Abraham, I. B.; Ibitoye, O. M.; Ojemuyiwa, E. Z.; Tayyib, M. R.; Sulaiman, S. E.; Ganiyu, R. A.; Ogunwale, K. A.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa
    Introduction: Insulin resistance, a condition in which cells do not respond adequately to insulin, plays a crucial role in diabetes and related metabolic disorders. This study investigated the association between handgrip strength (HGS), Insulin sensitivity, and β-cell function in non-diabetic Nigerian young adults. Materials and Methods: A total of 158 participants were used in this cross-sectional study. They were assessed for HGS, body mass index (BMI), fasting blood glucose (FBG), fasting Insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and homeostatic model assessment of β-cell function (HOMA-β). Assessments of normal distribution, descriptive statistics, subgroup analysis, Pearson's correlation, and regression models were done to analyse relationships and predict insulin and beta cell sensitivity. Multiple regression models were adjusted for confounders, and statistical significance was determined at p<0.01 or 0.05. Results: The individuals exhibited acceptable physical and metabolic well-being, with males having an average Absolute HGS (AHGS) of 59.92 kg and females having an average AHGS of 43.83 kg. The average Relative HGS (RHGS) was 2.87 for males and 2.13 for females, with an overall average BMI of 21.29 kg/m2. Strong relationships were observed between HGS (both left and right) and insulin sensitivity (measured by HOMA-IR), as well as pancreatic beta cell function (measured by HOMA-β) (p<0.01) and across other metabolic parameters (p<0.01). The differences in these associations were more evident in males than females. Male participants displayed relatively higher associations between HGS and both HOMA indices. In contrast, female individuals demonstrated weaker and statistically insignificant connections, which could result from physical, lifestyle, or hormonal disparities. Conclusion: This study is the first to show that HGS substantially indicates insulin sensitivity and beta cell function in a young, non-diabetic Nigerian population. The findings suggest that HGS could be a potential screening tool for managing insulin resistance and a feasible approach to enhancing metabolic health. Additional investigation is necessary to examine the fundamental processes and authenticate these findings in more extensive populations
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    Effect of gliclazide on uric acid and C-reactive protein in alloxan-induced diabetic rats
    (Published by University of Ilorin, Ilorin, Nigeria, 2012) Ojulari, L. S.; Biliaminu, S. A.; Dangana, E. O.; Abdulazeez, F. I.; Ayinde, T. O.; Adegoke, O. A.
    global health. It contributes to oxidative stress and also induces inflammation and hence severe complications. Several drugs have been introduced so far to salvage this metabolic disease alongside its complications. Objectives: This study was designed to investigate the effects of gliclazide on serum uric acid and C-reactive protein (a biomarker of inflammation) in alloxan-induced diabetic rats. Materials and Methods: Sixteen wistar rats were divided into 4 experimental groups with four rats each; Group A-control (Drug vehicle), Group B-diabetic, Group C- diabetic/gliclazide (10mg/kg twice daily for 28days) and Group D-normal/gliclazide (10mg/kg twice daily for 28 days). At the end of the experimental period (four weeks), animals in all groups were fasted for 12 hours and blood samples were taken by cardiac puncture for determination of serum uric acid and C-reactive protein (CRP) levels. Results: The study shows no significant statistical change in the serum uric acid levels (p>0.05) when the Experimental groups were compared with the controls. On the other hand, there was significant decrease (p<0.05) in CRP levels when values in the controls were compared with diabetic treated and normal treated groups. Conclusion: This finding may suggests that gliclazide possesses cardioprotective property since CRP has been implicated in atherosclerotic changes which is a common complication of diabetes mellitus. This may be through its anti-inflammatory effect by reducing the plasma concentration of IL-6, which is produced predominantly by macrophages and so prevents diabetic complications.
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    Effectiveness of Vitamin C Consumption In Pregnancy On Dexamethasone Induced Low Birth Weight
    (Published by College of Health Sciences, University of Ilorin, Ilorin, Nigeria, 2011) Ojulari, L. S.; Olatinwo, A. W. O.; Adegoke, O. A
    Synthetic glucocorticoids, including dexamethasone, have been shown to induce intrauterine growth retardation (IUGR) when administered in the last trimester of pregnancy. This study was designed to investigate the effect of vitamin C on dexamethasone-induced low birth weight using an experimental model in albino rats. Pregnant Sprague Dawley rats were divided into four groups: vehicle control, vitamin C treated (100 mg/kg), dexamethasone treated (bolus dose of 100 µg/kg on day 13, then 200 µg/kg daily until term), and combination treatment (vitamin C plus dexamethasone). Parameters measured included weight and size of litters, gestation period, and maternal weight gain. The results showed that although dexamethasone caused low birth weight, vitamin C had no significant (p > 0.05) effect on reversing dexamethasone-induced low birth weight, litter size, or gestation period. The study concluded that vitamin C may not influence the mechanisms by which dexamethasone induces low birth weight.
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    Ficus exasperata leaves aqueous extract influences pathophysiologic mechanisms of diabetic peripheral neuropathy in a rat model.
    (Open Science Publishers LLP, 2023-09-04) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Ajibare, A. J.; Akintoye, O. O.; Jimoh, O. S.; Ananias, E. N.; Owoyemi, J. O.; Ibiyeye, V. O.; Ojulari, L. S.
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    Nauclea latifolia (African peach) attenuates gastric acid secretion in rats with ethanol-induced ulceration
    (Published by Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria, 2021) Balogun, M. E.; Umahi, G. O.; Ayinde, T. O.; Oluwasola, A.; Busari, A. O.; Ajibola, K. A.; Yusuf, R. O.; Ojulari, L. S.
    Objective: The ethanolic leaf extract of N. latifolia (EENL) was investigated for its gastric acid antisecretory effects on ethanol-induced gastric ulcerated rats using an in vivo assay. Methods: Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg of EENL as the test groups, respectively before ulcer induction. Gastric acid secretion parameters and ulcerated areas were evaluated. Results: Pretreatment with EENL showed significant (P < 0.05) reduction in gastric volume, total acidity and ulcer index while the pH of gastric content increased significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group exhibited significantly severe mucosal injury and EENL or omeprazole offered significant (P < 0.05) protection against gastric mucosal injuries. Conclusion: The study suggests that EENL attenuates gastric acid secretion and ulceration induced by ethanol in Wistar rat. The observed pharmacological activities might be mediated via antisecretory and cytoprotective mechanisms.
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    The Effect of Metformin on Serum Levels of FSH, LH, Oestrogen and Progesterone in Diabetic Rats
    (College of Health Sciences, University of Ilorin, Ilorin, Nigeria, 2013) Ojulari, L. S.; Biliaminu, S. A.; Ahmed, T. T.; Abdulazeez, F. I.; Oyekunle, O. F.; Niyi-Odumosu, F. A.; Adegoke, O. A.
    Diabetes mellitus represents one of the greatest global health threats. It contributes to sub-fertility in females and impairs the normal menstrual cycle and ovulation. This study was designed to investigate the effect of oral administration of metformin on FSH, LH, oestrogen, and progesterone in diabetic rats. Twenty female rats were divided into four experimental groups of five rats each. Group A (control) received distilled water ad libitum. Group B were diabetic untreated; Group C received metformin only; Group D were diabetic and received metformin. At the end of the four-week treatment period, blood samples were collected for hormone assays. The results showed significant (P<0.05) reductions in FSH and LH levels in all experimental groups compared to control. Progesterone levels significantly increased in Groups B and D compared to control, while oestrogen levels were reduced in all experimental groups but insignificantly (P>0.05). The study suggests that metformin’s ovulation-inducing effect is likely due to its direct action on the ovary, and not solely due to improved insulin sensitivity.