Nauclea latifolia (African peach) attenuates gastric acid secretion in rats with ethanol-induced ulceration
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Date
2021
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Published by Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria
Abstract
Objective: The ethanolic leaf extract of N. latifolia (EENL) was investigated for its gastric acid antisecretory effects on ethanol-induced gastric ulcerated rats using an in vivo assay. Methods: Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg of EENL as the test groups, respectively before ulcer induction. Gastric acid secretion parameters and ulcerated areas were evaluated. Results: Pretreatment with EENL showed significant (P < 0.05) reduction in gastric volume, total acidity and ulcer index while the pH of gastric content increased significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group exhibited significantly severe mucosal injury and EENL or omeprazole offered significant (P < 0.05) protection against gastric mucosal injuries. Conclusion: The study suggests that EENL attenuates gastric acid secretion and ulceration induced by ethanol in Wistar rat. The observed pharmacological activities might be mediated via antisecretory and cytoprotective mechanisms.
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Keywords
Nauclea latifolia, Antacid, Antisecretory, Ethanol, Gastric ulcers
Citation
Balogun, M. E., Umahi, G. O., Ayinde, T. O., Oluwasola, A., Busari, A. O., Ajibola, K. A., Yusuf, R. O., & Ojulari, L. S. (2021). Nauclea latifolia (African peach) attenuates gastric acid secretion in rats with ethanol-induced ulceration. Al-Hikmah Journal of Health Sciences, 1 (1), 29-35, Published by Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria