Nauclea latifolia (African peach) attenuates gastric acid secretion in rats with ethanol-induced ulceration

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dc.contributor.authorBalogun, M. E.
dc.contributor.authorUmahi, G. O.
dc.contributor.authorAyinde, T. O.
dc.contributor.authorOluwasola, A.
dc.contributor.authorBusari, A. O.
dc.contributor.authorAjibola, K. A.
dc.contributor.authorYusuf, R. O.
dc.contributor.authorOjulari, L. S.
dc.date.accessioned2025-05-05T13:35:53Z
dc.date.available2025-05-05T13:35:53Z
dc.date.issued2021
dc.description.abstractObjective: The ethanolic leaf extract of N. latifolia (EENL) was investigated for its gastric acid antisecretory effects on ethanol-induced gastric ulcerated rats using an in vivo assay. Methods: Gastric mucosal ulceration was induced experimentally in Groups 2 to 5 rats using ethanol. Five groups of rats were orally pretreated with 3% Tween-80 only as vehicle group, 3% Tween-80 as ulcer group, 20 mg/kg of omeprazole as positive group, 250 and 500 mg/kg of EENL as the test groups, respectively before ulcer induction. Gastric acid secretion parameters and ulcerated areas were evaluated. Results: Pretreatment with EENL showed significant (P < 0.05) reduction in gastric volume, total acidity and ulcer index while the pH of gastric content increased significantly (P < 0.05) in rats with ethanol-induced ulcer. Ulcer group exhibited significantly severe mucosal injury and EENL or omeprazole offered significant (P < 0.05) protection against gastric mucosal injuries. Conclusion: The study suggests that EENL attenuates gastric acid secretion and ulceration induced by ethanol in Wistar rat. The observed pharmacological activities might be mediated via antisecretory and cytoprotective mechanisms.
dc.identifier.citationBalogun, M. E., Umahi, G. O., Ayinde, T. O., Oluwasola, A., Busari, A. O., Ajibola, K. A., Yusuf, R. O., & Ojulari, L. S. (2021). Nauclea latifolia (African peach) attenuates gastric acid secretion in rats with ethanol-induced ulceration. Al-Hikmah Journal of Health Sciences, 1 (1), 29-35, Published by Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria
dc.identifier.issn2811-1524
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16072
dc.language.isoen
dc.publisherPublished by Faculty of Health Sciences, Al-Hikmah University, Ilorin, Nigeria
dc.relation.ispartofseries1 (1); 29-35
dc.subjectNauclea latifolia
dc.subjectAntacid
dc.subjectAntisecretory
dc.subjectEthanol
dc.subjectGastric ulcers
dc.titleNauclea latifolia (African peach) attenuates gastric acid secretion in rats with ethanol-induced ulceration
dc.typeArticle

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