Effect of gliclazide on uric acid and C-reactive protein in alloxan-induced diabetic rats
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Date
2012
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Published by University of Ilorin, Ilorin, Nigeria
Abstract
global health. It contributes to oxidative stress and also induces inflammation and hence severe
complications. Several drugs have been introduced so far to salvage this metabolic disease
alongside its complications. Objectives: This study was designed to investigate the effects of
gliclazide on serum uric acid and C-reactive protein (a biomarker of inflammation) in alloxan-induced
diabetic rats. Materials and Methods: Sixteen wistar rats were divided into 4
experimental groups with four rats each; Group A-control (Drug vehicle), Group B-diabetic,
Group C- diabetic/gliclazide (10mg/kg twice daily for 28days) and Group D-normal/gliclazide
(10mg/kg twice daily for 28 days). At the end of the experimental period (four weeks), animals in
all groups were fasted for 12 hours and blood samples were taken by cardiac puncture for
determination of serum uric acid and C-reactive protein (CRP) levels. Results: The study shows
no significant statistical change in the serum uric acid levels (p>0.05) when the Experimental
groups were compared with the controls. On the other hand, there was significant decrease
(p<0.05) in CRP levels when values in the controls were compared with diabetic treated and
normal treated groups. Conclusion: This finding may suggests that gliclazide possesses cardioprotective
property since CRP has been implicated in atherosclerotic changes which is a common
complication of diabetes mellitus. This may be through its anti-inflammatory effect by reducing
the plasma concentration of IL-6, which is produced predominantly by macrophages and so
prevents diabetic complications.
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Keywords
Gliclazide, diabetes mellitus, uric acid, C-reactive protein
Citation
Ojulari, L. S., Biliaminu, S. A., Dangana, E. O., Abdulazeez, F. I., Ayinde, T. O., & Adegoke, O. A. (2012). Effect of gliclazide on uric acid and C-reactive protein in alloxan-induced diabetic rats. Centrepoint Journal (Science Edition), 18 (2), 139-146