Effect of gliclazide on uric acid and C-reactive protein in alloxan-induced diabetic rats

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dc.contributor.authorOjulari, L. S.
dc.contributor.authorBiliaminu, S. A.
dc.contributor.authorDangana, E. O.
dc.contributor.authorAbdulazeez, F. I.
dc.contributor.authorAyinde, T. O.
dc.contributor.authorAdegoke, O. A.
dc.date.accessioned2025-05-05T13:31:41Z
dc.date.available2025-05-05T13:31:41Z
dc.date.issued2012
dc.description.abstractglobal health. It contributes to oxidative stress and also induces inflammation and hence severe complications. Several drugs have been introduced so far to salvage this metabolic disease alongside its complications. Objectives: This study was designed to investigate the effects of gliclazide on serum uric acid and C-reactive protein (a biomarker of inflammation) in alloxan-induced diabetic rats. Materials and Methods: Sixteen wistar rats were divided into 4 experimental groups with four rats each; Group A-control (Drug vehicle), Group B-diabetic, Group C- diabetic/gliclazide (10mg/kg twice daily for 28days) and Group D-normal/gliclazide (10mg/kg twice daily for 28 days). At the end of the experimental period (four weeks), animals in all groups were fasted for 12 hours and blood samples were taken by cardiac puncture for determination of serum uric acid and C-reactive protein (CRP) levels. Results: The study shows no significant statistical change in the serum uric acid levels (p>0.05) when the Experimental groups were compared with the controls. On the other hand, there was significant decrease (p<0.05) in CRP levels when values in the controls were compared with diabetic treated and normal treated groups. Conclusion: This finding may suggests that gliclazide possesses cardioprotective property since CRP has been implicated in atherosclerotic changes which is a common complication of diabetes mellitus. This may be through its anti-inflammatory effect by reducing the plasma concentration of IL-6, which is produced predominantly by macrophages and so prevents diabetic complications.
dc.identifier.citationOjulari, L. S., Biliaminu, S. A., Dangana, E. O., Abdulazeez, F. I., Ayinde, T. O., & Adegoke, O. A. (2012). Effect of gliclazide on uric acid and C-reactive protein in alloxan-induced diabetic rats. Centrepoint Journal (Science Edition), 18 (2), 139-146
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16051
dc.language.isoen
dc.publisherPublished by University of Ilorin, Ilorin, Nigeria
dc.relation.ispartofseries18 (2); 139-146
dc.subjectGliclazide
dc.subjectdiabetes mellitus
dc.subjecturic acid
dc.subjectC-reactive protein
dc.titleEffect of gliclazide on uric acid and C-reactive protein in alloxan-induced diabetic rats
dc.typeArticle

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