Browsing by Author "Ogbole, Omonike"

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    Antioxidant, Brine Shrimp Lethality, and Antiproliferative Properties of Gel and Leaf Extracts of Aloe schweinfurthii and Aloe vera
    (JOURNAL OF HERBS, SPICES & MEDICINAL PLANTS, 2017) Salawu, Kayode; Ayaiyeoba, Edith; Ogbole, Omonike; Adeniji, Johnson; Faleye, Temitope; Agunu, Abdulkarim
    Leaf and gel extracts of Aloe schweinfurthii and A. vera were subjected to in vitro antioxidant assay using 2,2-diphennyl-1picryl hydrazyl (DPPH), brine shrimp lethality bioassay, and cytotoxicity using the MTT assay with two human cancer cell lines: Rd and Hep-2c. Extracts of A. schweinfurthii gel had IC values of 44.59; A. vera gel, 41.48, and A. vera leaf, 38.84 µg.mL , had similar DPPH radical-scavenging properties and were more active than A. schweinfurthii leaf. Ascorbic acid had an IC of 9.26 ± 0.14 µg.mL –1 . Aloe vera leaf (LC 50 = 325 ± 5.38 µg.mL ) was more active than the other three extracts in the BSL assay. The gel extracts of A. schweinfurthii (CC 50 = 4.06 µg.mL on Rd and 9.00 µg.mL –1 on Hep-2c) and A. vera (CC 50 –1 = 4.31 µg.mL on Rd, 9.06 µg.mL –1 on Hep-2c) elicited similar and more potent cytotoxicity comparable to cyclophosphamide, with CC = 2.2 µg.mL –1 on Rd and 2.66 µg.mL –1 on Hep-2c. Leaf extracts were less active than gel extracts. This study showed that A. schweinfurthii gel, A. vera gel and leaf had weak DPPH activity which were similar. Aloe vera and A. schweinfurthii did not elicit potent cytotoxicity in BSL assay. The gels from both Aloe species displayed antipoliferative activity on Rd and Hep-2c, two human cell cancer lines. 50 50 –1 50 –1 –1
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    RADICAL SCAVENGING AND CYTOTOXICITY EVALUATION OF EIGHT EXTRACTS OF CITRUS LIMON AND CITRUS AURANTIFOLIA
    (Nigerian Journal of Natural Product and Medicines, 2016) Ajaiyeoba, Edith; Salawu, Kayode; Ogbole, Omonike
    Cancer is a global cause of death characterized by uncontrolled proliferation and spread of abnormal cells. Eight extracts composed of the leaf, stem bark, seeds and juice of each of Citrus limon and C. aurantifolia were subjected to in vitro antioxidant assay using DPPH, brine shrimp lethality bioassay of 28.2±0.11 and 47.2±0.39 µg/mL, respectively and displayed better radical scavenging activity compared to the other extracts, Ascorbic acid, the reference drug, had an IC of 9.2±0.14 µg/mL. Citrus limon stem bark 50 =10.0±0.33 = 5.0±0.74 µg/mL 50 50 =98.76±0.15 µg/mL 50 =4.02±2.85 µg/mL, CC 50 =5.45±2.8 µg/mL =2.23±0.14 µg/ mL, CC =2.66±0.8 µg/mL 50 50 50 50