Browsing by Author "Obaleye, Joshua Ayoola"

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    Mixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studies
    (Library and Publications Committee, University of Ilorin, Ilorin, Nigeria., 2019) Babamale, Halimah Funmilayo; Rajee, Abdullahi Ola; Obaleye, Joshua Ayoola; Lawal, Amudat; Bamigboye, Mercy Obaleye; Lawal, Misitura; Sa'ad, H.O.
    Some transition metal complexes of mixed artemether, ascorbic acid and lumefantrine have been synthesized and characterized using UV/Vis, FTIR, Atomic Absorption Spectroscopy (AAS) and Gas chromatography-Mass Spectroscopy (GC-MS). The results revealed that the artemether and ascorbic acid are chelating ligands and coordinates through the oxygen of the carbonyl groups while lumefantrine coordinates through the hydroxyl group in a monodentate fashion. The metal complexes were investigated for biological activity using five bacterial species - Staphylococcus aureus, Escherichia coli, Bacillus aureus and Pseudomonas aeruginosa. It was observed that the synthesized complexes were more effective towards the five bacteria species than the free drugs.
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    Synthesis, Characterization and Antimicrobial Activity of Amodiaquine and Sulphadoxine Mixed Ligand-metal Complexes
    (The Nigerian Society of Biochemistry and Molecular biology., 2014) Obaleye, Joshua Ayoola; Lawal, Amudat; Rajee, Abdullahi Ola; Shittu, Fatimah B.
    Four mixed ligand metal complexes [Co(AMD)(SUF)Cl2],[Cu(AMD)(SUF)Cl2], [Ni(AMD)(SUF)Cl2] and [Zn(AMD)(SUF)Cl2] of Amodiaquine and Sulphadoxine were synthesized. The complexes formed were characterized by solubility and melting point determination, conductivity measurements,, infrared, ultraviolet and NMR spectroscopy and elemental analysis. The analytical and spectroscopic data revealed the formation of new complexes. The ligands used were found to acts as monodentates. Sulphadoxine, coordination occurs through the N atom of the NH, group in the complexes while for amodiaquine, coordination occurs also through the nitrogen of the quinoline group. Hence, tetrahedral geometry was assigned for all the synthesized complexes, since they also coordinate with the chloride ions. Investigation of the antibacterial study was also carried out which indicated that the synthesized complexes exhibits some inhibitory activities higher than their parent ligands most especially for the Co(II) and Cu(I) complexes.