Synthesis, Characterization and Antimicrobial Activity of Amodiaquine and Sulphadoxine Mixed Ligand-metal Complexes
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
The Nigerian Society of Biochemistry and Molecular biology.
Abstract
Four mixed ligand metal complexes [Co(AMD)(SUF)Cl2],[Cu(AMD)(SUF)Cl2], [Ni(AMD)(SUF)Cl2] and [Zn(AMD)(SUF)Cl2] of Amodiaquine and Sulphadoxine were synthesized. The complexes formed were characterized by solubility and melting point determination, conductivity measurements,, infrared, ultraviolet and NMR spectroscopy and elemental analysis. The analytical and spectroscopic data revealed the formation of new complexes. The ligands used were found to acts as monodentates. Sulphadoxine, coordination occurs through the N atom of the NH, group in the complexes while for amodiaquine, coordination occurs also through the nitrogen of the quinoline group. Hence, tetrahedral geometry was assigned for all the synthesized complexes, since they also coordinate with the chloride ions. Investigation of the antibacterial study was also carried out which indicated that the synthesized complexes exhibits some inhibitory activities higher than their parent ligands most especially for the Co(II) and Cu(I) complexes.
Description
Keywords
Amodiaquine, Sulphadoxine, Ligand, Antibacterial
Citation
Obaleye, J.A., Lawal, A., Rajee, A.O., Babamale, H.F. & Shittu, F.B. (2014). Synthesis, Characterization and Antimicrobial Activity of mixed Amodiaquine and Sulphadoxine mixed Ligands – metal Complexes. Nigerian Journal of Biochemistry and Molecular Biology – NJBMB: 29(2):170-179.