Synthesis, Characterization and Antimicrobial Activity of Amodiaquine and Sulphadoxine Mixed Ligand-metal Complexes

Simple item page
dc.contributor.authorObaleye, Joshua Ayoola
dc.contributor.authorLawal, Amudat
dc.contributor.authorRajee, Abdullahi Ola
dc.contributor.authorShittu, Fatimah B.
dc.date.accessioned2023-05-16T14:18:08Z
dc.date.available2023-05-16T14:18:08Z
dc.date.issued2014
dc.description.abstractFour mixed ligand metal complexes [Co(AMD)(SUF)Cl2],[Cu(AMD)(SUF)Cl2], [Ni(AMD)(SUF)Cl2] and [Zn(AMD)(SUF)Cl2] of Amodiaquine and Sulphadoxine were synthesized. The complexes formed were characterized by solubility and melting point determination, conductivity measurements,, infrared, ultraviolet and NMR spectroscopy and elemental analysis. The analytical and spectroscopic data revealed the formation of new complexes. The ligands used were found to acts as monodentates. Sulphadoxine, coordination occurs through the N atom of the NH, group in the complexes while for amodiaquine, coordination occurs also through the nitrogen of the quinoline group. Hence, tetrahedral geometry was assigned for all the synthesized complexes, since they also coordinate with the chloride ions. Investigation of the antibacterial study was also carried out which indicated that the synthesized complexes exhibits some inhibitory activities higher than their parent ligands most especially for the Co(II) and Cu(I) complexes.en_US
dc.identifier.citationObaleye, J.A., Lawal, A., Rajee, A.O., Babamale, H.F. & Shittu, F.B. (2014). Synthesis, Characterization and Antimicrobial Activity of mixed Amodiaquine and Sulphadoxine mixed Ligands – metal Complexes. Nigerian Journal of Biochemistry and Molecular Biology – NJBMB: 29(2):170-179.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/10252
dc.language.isoenen_US
dc.publisherThe Nigerian Society of Biochemistry and Molecular biology.en_US
dc.relation.ispartofseries29(2);170-178
dc.subjectAmodiaquine, Sulphadoxine, Ligand, Antibacterialen_US
dc.titleSynthesis, Characterization and Antimicrobial Activity of Amodiaquine and Sulphadoxine Mixed Ligand-metal Complexesen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
NJBMB 2014- LAWAL ET AL.pdf
Size:
3.41 MB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections