Browsing by Author "Ijaiya, M"

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    Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in North West Nigeria
    (Makerere University School of Medicine. College of Health Sciences, Kampala, Uganda, 2018-09-03) Oladosu-olayiwola, OR; Olawumi, H.O.; Babatunde, A.S; Ijaiya, M; Durotoye, I A.; Biliaminu, A.S; Ibraheem, R.M.
    Background: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study com- pares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results: The mean age of the respondents was 29.9±5.2 years. The median(25 th -75 th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000-1560.000ng/ml), 0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respec- tively which were significantly higher than the corresponding values in the controls of 520 (24.000-1030.000ng/ml), 0.05 (0.040-0.090ng/ml and 2.650 (2.125-3.400ng/ml) respectively, p<0.05 each. Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition.
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    PAI-1 and tPA as markers of severity among pre-eclamptics in a tertiary institution in north central Nigeria
    (College of Medicine, University of Ibadan, Nigeria., 2016) Oladosu-Olayiwola, OR; Olawumi, H.O.; Babatunde, A.S; Ijaiya, M; Durotoye, I A.; Biliaminu, AS; Ibraheem, RM; Ogunfemi, MK
    Objectives: Endothelial dysfunction contributes to the pathogenesis of pre-eclampsia as well as increased production of some factors such as tissue plasminogen activator (tPA) and plasminogen activator inhibitor type-1 (PAI-1). These factors are said to be biomarkers of pre-eclampsia but their role in assessing the severity of pre-eclampsia is under- reported. Methodology: A cross-sectional study involving 85 subjects with pre-eclampsia. They were classified clinically as having mild or severe pre-eclampsia using ACOG classification. Blood and urine samples were collected for determining tPA, PAI-1, D-dimer and proteinuria in the two groups. Clinical and laboratory values were compared using the IBM ® SPSS 20.0 (2011) soft ware packages. Results: The mean age of the respondents was 29.9±5.2 years. Forty-five (52.9%) of the subjects had severe pre-eclampsia while 40(47.1%) had mild pre-eclampsia. The median values of tPA and PAI-1 of subjects with severe pre-eclampsia were significantly higher than the corresponding values in subjects with mild pre-eclampsia (each p=0.001). There was a positive correlation between each of the tPA and PAI-1 levels with the degree of severity of pre-eclampsia (p=0.001 each). Conclusion: Fibrinolytic proteins like tPA and PAI- 1 are useful in assessing the severity of pre- eclampsia.
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    Survey of Current Practice of Labour Analgesia among Obstetricians in Nigeria: Implications for pain-free Labour Initiative
    (by College of Medicine and Allied Health Sciences, University of Sierra Leone., 2016-12) Raji, H.O; Suleiman, Z.A; Ijaiya, M; Abdul, I.F; Saka, M.J; Adebara, I; Adegboye, M.B
    Labour pain has been described as the worst possible pain known to mankind. It is more excruciating than cancer pain, phantom pain or toothache. Failure to relieve pain of any cause has been regarded as a violation of fundamental human rights. This study aimed to evaluate the current obstetrics analgesia practice among physicians in Nigeria, identify constraints to the practice and recommend solutions to improve the provision of such service to parturients. This descriptive cross-sectional questionnaire-based study on the availability and practice of intra-partum analgesia services was conducted among practitioners at the Departments of Obstetrics and Gynecology of 3 tertiary health institutions located in 3 of the 6 geopolitical zones of Nigeria. Of the 120 questionnaires distributed to the participants, 81 (67.5%) of the respondents returned completed questionnaires. The age range of the respondents was 25-44 years with a mean age of 30.8 and a male to female ratio (M: F) of 1.7: 1. Majority of the respondents, 76 (93.8%) believed that intra-partum analgesia was important, epidural analgesia was the most known method of intra-partum analgesia by 86.4% of the participants and epidural analgesia was the most preferred, 61.7% of respondents. Majority of respondents, 66 (81.5%), did not have an institutional policy or protocol on intra-partum analgesia. Doctors working in the same centre responded differently to the questions in the distributed questionnaires; and this is suggestive of lack of departmental harmonisation of clinical practice in the form of Standard Operating Protocol on intrapartum analgesia. Although there is a high level of knowledge of intrapartum analgesia among physicians, inconsistencies in its practice exist within and between tertiary hospitals in Nigeria. Notable absence of institutional policies on intra-partum analgesia at the practice facilities of the respondents was also observed.