Browsing by Author "Faramade, A.A.,"

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    Effect of Chronic Administration of Caffeine on Renal Function in Male Wistar Rats
    (Society for the Conservation of Phytofuels and Sciences., 2022) Ayinde, T.O.,; Ojulari, L.S.,; Afodun, A.M.,; Balogun, M.E.,; Faramade, A.A.,; Raji, A.O.,; Liadi, M.T.,; Belewu, M.A.
    Caffeine is one of the most widely consumed of all beverages in the World that is capable of stimulating the nervous system, producing alertness of short duration without much regards to organ affectations. Twenty-one (21) male Wistar rats were randomly divided into three (3) groups of 7 rats each as follows: Group I was the control and was given 0.5 ml of NaCl, Groups II and III were administered 0.38 mg/kg and 1.14 mg/kg of caffeine respectively for 14 days. Assessment of renal function was evaluated by collection of urine and blood samples for urinalysis and electrolytes, urea, and creatinine analysis respectively. Urinalysis result precisely showed that protein was positive (+) with a pH of 5.5 in the control group. The LD animals revealed bilirubin (2+), protein (+) with a pH of 5.0. The HD group showed bilirubin (2+), protein (3+) with a pH of 3.5. There was significant (p<0.05) increase in serum urea and creatinine of LD and HD. The serum sodium level was significantly (p<0.05) reduced in LD, while serum potassium level was significantly (p<0.05) increased in the HD group. Chronic consumption of caffeine should be with moderation and at a very lower dose to prevent gradual untoward effects on functions of the kidneys, especially in an already compromised renal status.
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    Effect of Chronic Administration of Caffeine on Renal Function in Male Wistar Rats.
    (Society for the Conservation of Phytofuels and Sciences., 2022) Ayinde, T.O.,; Ojulari, L.S.,; Afodun, A.M.,; Balogun, M.E.,; Faramade, A.A.,; Raji, A.O.,; Liadi, M.T.,; Belewu, M.A.
    Caffeine is one of the most widely consumed of all beverages in the World that is capable of stimulating the nervous system, producing alertness of short duration without much regards to organ affectations. Twenty-one (21) male Wistar rats were randomly divided into three (3) groups of 7 rats each as follows: Group I was the control and was given 0.5 ml of NaCl, Groups II and III were administered 0.38 mg/kg and 1.14 mg/kg of caffeine respectively for 14 days. Assessment of renal function was evaluated by collection of urine and blood samples for urinalysis and electrolytes, urea, and creatinine analysis respectively. Urinalysis result precisely showed that protein was positive (+) with a pH of 5.5 in the control group. The LD animals revealed bilirubin (2+), protein (+) with a pH of 5.0. The HD group showed bilirubin (2+), protein (3+) with a pH of 3.5. There was significant (p<0.05) increase in serum urea and creatinine of LD and HD. The serum sodium level was significantly (p<0.05) reduced in LD, while serum potassium level was significantly (p<0.05) increased in the HD group. Chronic consumption of caffeine should be with moderation and at a very lower dose to prevent gradual untoward effects on functions of the kidneys, especially in an already compromised renal status.
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    Effect of Chronic Administration of Medroxylprogesterone (Depo-Provera) Contraceptive on Renal Function in Female Wistar Rats.
    (Association of Specialist Medical Doctors in Academics, 2022) Ayinde, T.O.,; Ojulari, LS.,; Faramade, A.A.,; Amali, M.O.,; Olayaki, L.A.,; Ajao, M.S
    Background: Medroxyprogesterone (Depo-Provera) is an injectable contraceptive used in preventing ovulation, and thus pregnancy. Progesterone used in oral contraceptives has been implicated in some renal diseases. Thus, Depo-Provera which is a form of progesterone that is associated with some adverse effects must be cautiously used. The study was carried out to investigate the effect of chronic administration of Depo-Provera on renal functions in female Wistar rats. Methodology: Twenty-four female Wistar rats were randomly grouped into four groups of 6 rats each with group I as control. Group II was administered 2.14mg/kg (low dose), group III was administered 4.28mg/kg (moderate dose), and group IV was administered 8.56mg/kg (high dose) of Depo-Provera once. Weekly urine analysis was done throughout the three months of the study, following which the rats were euthanized, and blood samples collected for serum electrolytes, urea and creatinine. Result: The moderate and high dose groups showed significant (p<0.05) decrease in calcium, and significant (p<0.05) increase in potassium, urea and creatinine levels. There was also significant (p<0.05) decrease in sodium of high dose, and significant (p<0.05) increase in creatinine of low dose groups; however, there was no significant (p>0.05) change in serum phosphate and chloride levels globally. The urinalysis results summarily showed protein was positive (+) with a pH of 5.5 in low dose group, while the moderate and high dose groups were positive for bilirubin (2+), and protein (3+) with a pH of 4.0. Conclusion: Depo-Provera should be cautiously used to avoid renal dysfunction due to accumulation of urea and creatinine, and loss of bone mineral density which can predispose to osteoporosis. Keywords: Creatinine, Medroxyprogesterone, Renal functions, Serum electrolytes