Effect of Chronic Administration of Caffeine on Renal Function in Male Wistar Rats
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Date
2022
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Publisher
Society for the Conservation of Phytofuels and Sciences.
Abstract
Caffeine is one of the most widely consumed of all beverages in the World that is capable
of stimulating the nervous system, producing alertness of short duration without much
regards to organ affectations. Twenty-one (21) male Wistar rats were randomly divided
into three (3) groups of 7 rats each as follows: Group I was the control and was given 0.5
ml of NaCl, Groups II and III were administered 0.38 mg/kg and 1.14 mg/kg of caffeine
respectively for 14 days. Assessment of renal function was evaluated by collection of urine
and blood samples for urinalysis and electrolytes, urea, and creatinine analysis
respectively. Urinalysis result precisely showed that protein was positive (+) with a pH of
5.5 in the control group. The LD animals revealed bilirubin (2+), protein (+) with a pH of
5.0. The HD group showed bilirubin (2+), protein (3+) with a pH of 3.5. There was
significant (p<0.05) increase in serum urea and creatinine of LD and HD. The serum
sodium level was significantly (p<0.05) reduced in LD, while serum potassium level was
significantly (p<0.05) increased in the HD group. Chronic consumption of caffeine should be with moderation and at a very lower dose to prevent gradual untoward effects on
functions of the kidneys, especially in an already compromised renal status.
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Citation
Caffeine, Creatinine, Urinalysis, Renal function, Urea, Electrolytes