Browsing by Author "Durotoye, I. A."
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Item Determination of Normal and Variant Hemoglobin using Capillary Electrophoresis among Voluntary Blood Donors in North Central Nigeria: Implications on Blood Transfusion Services(Faculty of Medicine and Health Sciences - Omdurman Islamic University, 2021) Durotoye, I. A.; Salaudeen, A. G.; Sanni, E. O.; Babatunde, A. S.; Durowade, A. K.; Olawumi, H. O.; Akande, T. M.; Musa, O. I.Abstract Background: Voluntary non-remunerated blood donation is a strategy adopted by World Health Organization aimed at ensuring safety and adequacy of blood supply. Sub-Saharan Africa has a high prevalence of hemoglobin disorders and therefore needs to adopt stringent measures in donor selection to ensure safety for the recipient of blood transfusion. This study aimed to analyze normal and variant hemoglobin among voluntary blood donors. Methods: In this descriptive cross-sectional study, 100 prospective blood donors including 55 (55%) males and 45 (45%) females, aged 18–34 years were recruited. Capillary electrophoresis using the Minicap system was used for determining the hemoglobin variants in alkaline buffer (PH 9.4). Data analysis was done using SPSS version 20 and p-value < 0.05 was considered as the level of significance Results: The mean age of the participants was 22.23 ± 3.3 SD years. The proportion of participants with genotype AA was 67 (67%), those with AS were 17 (22 %), while those with AC were 11 (11 %). While Hb A ≥ 90% was noted in 67 (67%) blood donors, Hb S was seen in 22 (22%) and Hb A2 > 3.5% in 57 (57%). Hb F > 2% was observed in 3% of the studied participants Conclusion: Variant hemoglobin is common among blood donors and this should be taken into consideration whenever blood is being crossmatched for recipients of blood transfusion. Data from this study will be useful in raising awareness and genetic counseling.Item Haemostatic Parameters during Pregnancy in Ilorin, Nigeria(College of Health Sciences, University of Ilorin, 2012) Durotoye, I. A.; Babatunde, A.S.; Olawumi, H. O.; Olatunji, P. O.; Adewuyi, J. O.Abstract The objective of this study was to document the effect of pregnancy on some haemostatic parameters (Prothrombin time [PT], activated partial thromboplastin time [APTT], fibrinogen concentration, euglobin clot lysis time [ELT], and platelet count) in different trimesters of pregnancy. One hundred and eighty women with non-complicated pregnancy within the age range of 17-40 years (mean± SD 27.1±3.9years) were recruited for the study and sixty non-pregnant, normotensive apparently healthy age-matched women were used as control. All haemostatic parameters evaluated were determined using standard techniques. Significant differences were observed between the haemostatic parameters studied and controls except for platelet count. Prothrombin time was significantly shorter (p<0.001) and fibrinogen significantly higher (p<0.001) as pregnancy advanced but, other parameters were not influenced by the gestational age. There was a significant difference between the fibrinogen level in older subject compared with subject of younger age group with a mean of 5.5g/l and 4.0g/l (p<0.05) respectively. There was no significant relationship in the haemostatic parameters with parity and educational level of all the subjects. In conclusion, the results of haemostatic screening tests in this study suggest some degree of activation in pregnant women.Item Normal CD4+ Cell Count Range Amongst Healthy Nigerian Population In Ilorin,(International Association of Providers of AIDS Care., 2014) Afolabi, J. K.; Fadeyi, A; Desalu, O. O.; Durotoye, I. A.; Fawibe, A. E.; Adeboye, M. A. N.; Olawumi, H. O.; Babatunde, A. S.; Ernest, S. K.; Aderibigbe, S. A.; Saadu, R.; Salami, A. K.; Aboyeji, A. P.Background: For the establishment and monitoring of the immune status, CD4 count is critical. Objectives: To determine the CD4 count range of apparently healthy Nigerians resident in Ilorin and compare with the national value. Methods: An automated blood analyzer was used to determine the full blood count and CD4 count. The percentage of CD4 count was derived by using other variables. Results: Of the 1205 participants, the reference CD4 count (percentage of CD4) range for adult was 400 to 1288 cells/mm 3 (19%-48%) and for children was 582 to 3652 cells/mm 3 (17%-50%). CD4 count and percentage of CD4 were significantly (P 1⁄4 .001) higher in females than in males, and the CD4 count declined significantly with increasing age (r 1⁄4 .174, P .0001). The percentage of CD4 count shows less variation with age (r 1⁄4 .051, P 1⁄4 .076). Adult residents of Ilorin had significantly lower absolute mean CD4 count (808 + 260) than that of the national reference values of 847.0 + 307.0 cells/mm 3 (P 1⁄4 .001). Conclusion: We therefore advocate the use of CD4 count range derived in this study is lower than that of the national reference values.Item Pattern of Childhood Malignancies in Ilorin, Nigeria: Challenges and Strategies for Management in a Tertiary Health Institution.(Ibn Sina Trust, Bangladesh, A member of Bangladesh Journal Online, 2015) Babatunde, A. S.; Gobir, A. A.; Adeboye, M. A. N.; Adebayo-Oloko, A; Durotoye, I. A.Objective: The study was carried out to document the pattern of childhood malignant tumors which were diagnosed at the University of Ilorin Teaching Hospital, Ilorin, and compare with previous reports from other parts of Nigeria and elsewhere and also highlight the challenges andbstrategies for effective management of these diseases in our environment. Methods: A ten year retrospective analysis of all cancers diagnosed in children below the age of 18 years at the study centre between January 2000 and December 2009 was carried out. Case folders of all children diagnosed with malignant tumors within the study period were retrieved from the Cancer Registry Department of the Hospital and were analyzed with respect to age, gender, morphological or histological type of malignancy, extent of disease, treatment modality, and survival outcome. Results: Ninety nine (99) children were diagnosed with various malignancies during the study period. Sixty seven (67; 67.7%) were boys and 32 (32.3%) were girls giving a male to female ratio of 2:1. There were 22 cases (22.2%) recorded in children aged below 4 years and 72 cases (72.7%) were diagnosed in children between 4 -14 years. Lymphomas were the most prevalent malignancies encountered accounting for 54 cases (54.5%), Burkitt’s lymphoma constituted 43 (79.6%) of all lymphoma cases. The distribution of the five foremost malignancies recorded were as follows: Burkitt’s lymphoma (43 cases), Nephroblastoma (10 cases), Retinoblastoma (8 cases), Non Hodgkin’s lymphoma (7 cases) and Acute leukaemias (5 cases). Other malignancies included Osteogenic sarcoma (5), Hodgkin’s lymphoma (4), and 2 cases each of primary liver cell carcinoma, neuroblastoma, rhabdomyosarcoma and nasopharyngeal tumor. Conclusion: The distribution of the various childhood malignant tumors recorded in this study is similar to the pattern reported in previous studies from Nigeria and other countries. However, there appears to be a lower prevalence of leukemia recorded in this study compared to the earlier findings. The challenges which were identified in the diagnosis, management and overall outcome of our patients included limited number of diagnostic tools, late presentation in the hospital, high patient default rate, poverty, and shortage of chemotherapeutic drugs.