Browsing by Author "Biliaminu, S.A."
Now showing 1 - 20 of 30
Results Per Page
Sort Options
Item Acute and Sub-acute Toxicities of Defatted Ethanolic Extract of Moringa Oleifera seed in Albino Rats(West African Society for Pharmacology, 2015) Olorundare, O.E.; Bello, M.K.; Biliaminu, S.A.; Babatunde, A.S.; Ibrahim, O.O.K.; Anoka, A.A.Item Acute Kidney Injuries in Children with Severe Malaria: A comparative study of diagnostic criteria based on serum cystatin C and creatinine levels(College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khod, Muscat, Oman, 2020) Afolayan, FM; Adedoyin, OT; Abdulkadir, Mohammed Baba; Ibrahim, O.R.; Biliaminu, S.A.; Mokuolu, O.A.; Ojuawo, A.Objectives: Serum creatinine levels are often used to diagnose acute kidney injury (AKI), but may not necessarily accurately reflect changes in glomerular filtration rate (GFR). This study aimed to compare the prevalence of AKI in children with severe malaria using diagnostic criteria based on creatinine values in contrast to cystatin C. Methods: This prospective cross-sectional study was performed between June 2016 and May 2017 at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. A total of 170 children aged 0.5–14 years old with severe malaria were included. Serum cystatin C levels were determined using a particle-enhanced immunoturbidmetric assay method, while creatinine levels were measured using the Jaffe reaction. Renal function assessed using cystatin C-derived estimated GFR (eGFR) was compared to that measured using three sets of criteria based on creatinine values including the Kidney Disease: Improved Global Outcomes (KDIGO) and World Health Organization (WHO) criteria as well as an absolute creatinine cut-off value of >1.5 mg/dL. Results: Mean serum cystatin C and creatinine levels were 1.77 ± 1.37 mg/L and 1.23 ± 1.80 mg/dL, respectively (P = 0.002). According to the KDIGO, WHO and absolute creatinine criteria, the frequency of AKI was 32.4%, 7.6% and 16.5%, respectively. In contrast, the incidence of AKI based on cystatin C-derived eGFR was 51.8%. Overall, the rate of detection of AKI was significantly higher using cystatin C compared to the KDIGO, WHO and absolute creatinine criteria (P = 0.003, <0.001 and <0.001, respectively). Conclusion: Diagnostic criteria for AKI based on creatinine values may not indicate the actual burden of disease in children with severe malaria.Item Assisted Reproduction Technology: Comparison of Anesthetic Techniques for Oocyte Retrieval in a Tertiary Health Facility in Ilorin(2017) Omokanye, Lukman O.; Olatinwo, Abdulwaheed O.; Saadu, L.O.; Biliaminu, S.A.; Durowade, K A.; Salaudeen, A.GBackground: Transvaginal ultrasound‑guided oocyte retrieval (TUGOR) technique is minimally invasive and requires shorter time compared to previous techniques. Yet, it is a potentially stressful and painful procedure and thus requires some form of analgesia with or without sedation. The effects of various anesthetic techniques used for TUGOR on reproductive outcomes remain controversial. Aims and Objectives: This study aimed at comparing the efficacy of paracervical block (PCB) and conscious sedation for pain relief and pregnancy outcomes during TUGOR. Materials and Methods: This is a cross‑sectional comparative study of 137 eligible clients that underwent assisted reproduction program in our facility. All clients were treated with antagonist protocol for controlled ovarian hyperstimulation. The choice of analgesia for TUGOR was influenced by clients’ and/or clinicians’ preference. PCB and conscious sedation were administered for TUGOR in 66 and 71 clients, respectively. Pain was assessed using a 10‑cm Visual Analog Scale (VAS), while clients’ overall satisfaction was rated using Likert scoring system. Results: There was no statistically significant difference in the clinical pregnancy, miscarriage, and live birth rates between the two groups. The mean VAS 10‑point scores at 1, 6, and 24 h postretrieval and on the day of embryo transfer were significantly higher for paracervical group. The mean Likert score for conscious sedation group was significantly higher than that of paracervical group. Conclusion: Conscious sedation is superior to PCB as anesthetic/analgesic agent for pain relief and clients’ satisfaction for TUGOR. However, a multimodal approach to anesthesia/analgesia for TUGOR is suggested to further improve overall clients’ satisfaction.Item Assisted Reproduction Technology: Comparison of Clinical outcomes between day 3 and day 5 embryo transfer(College of Medicine KLE University, Belgaum, India, 2018) Omokanye, Lukman O.; Saadu, L.O.; Olatinwo, Abdulwaheed O.; Biliaminu, S.A.; Durowade, K A.; Panti, Abubakar A.; Salaudeen, A.G.BACKGROUND: Embryo transfer (ET) is a critical step in in vitro fertilization (IVF). Selecting the day of transfer for achieving the desired outcomes has been a great challenge. AIMS AND OBJECTIVES: The aim of this study was to compare the pregnancy rates of day 3 and day 5 ET in assisted conception. MATERIALS AND METHODS: This is a longitudinal prospective study of 122 eligible patients that underwent assisted reproduction program in our facility. All patients had controlled ovarian hyperstimulation using antagonist protocol. Patients with four or more zygotes were randomly allocated on day 1 to either day 3 or 5 transfers (58 vs. 64 patients). Fertilization was achieved through conventional IVF. Zygotes were kept in a single‑step medium (Global total®) for day 3 and 5 transfers, respectively. The morphologically best two or three embryos or blastocysts were chosen for transfer in both groups. RESULTS: The overall clinical pregnancy and live birth rates for both groups were 40.2% and 33.6%. There was no statistically significant difference between day 3 and day 5 transfer regarding clinical pregnancy rates (36.2% vs. 43.8% [P = 0.51]), live birth rates (27.6% vs. 9.1% [P = 1.0]), twinning rates (18.8% vs. 20% [P = 1.0]), and rates of early pregnancy loss (8.6% versus 4.7% P = [0.2]). CONCLUSION: In this study, the clinical outcomes of blastocyst transfer are similar to day 3 ET. This underscores the need for patient selection for the choice of days of ET. Further controlled randomized prospective studies with larger sample sizes are recommended.Item Assisted Reproduction Technology: Perceptions among infertile couples in Ilorin, Nigeria.(A taif University Saudi, 2017) Omokanye, Lukman O.; Olatinwo, Abdulwaheed O.; Durowade, K A.; Raji, S.T.; Biliaminu, S.A.; Salaudeen, A.GBackground: Infertility is a global health problem and a socially destabilizing condition for couples carrying several stigmas and a cause of marital disharmony. Assisted reproduction technologies (ARTs) offers a chance at parenthood to couples, who until recently would have had no hope of having a “biologically related” child. Aims and Objectives: This study aimed to determine the awareness and perception of ART services among infertile couples at a public health facility in Ilorin, Nigeria. Materials and Methods: This is a cross‑sectional descriptive study of consecutively consenting infertile couples seen at the ART unit of the Department of Obstetrics and Gynaecology, University of Ilorin Teaching Hospital, Ilorin, between January 1, 2012, and December 31, 2015. Results: The patients aged 22–52 years with a mean age of 36.1 ± 6.6 years and mean duration of infertility of 7.3 ± 5.8 years. Most (60.8%) belonged to middle social class. Of the 559 infertile couples interviewed, 87.3% were aware of ART services. Less than half (48.8%) were aware of surrogacy while majority (85.7%) rejected the use of surrogate mother. Reasons to decline surrogacy were desire to carry one’s own child (51.7%) and “do not like the idea” (22.3%). Female partner age, duration of infertility, and religion had a significant influence on acceptance of donor egg (P < 0.05). Conclusion: Despite the high level of awareness of ART, its low utilization remains a gap in the delivery of these services. Government and nongovernmental agencies need to institute interventions to stem the trend.Item Assisted Reproductive Technology: Experience from a Public Tertiary Institution in North Central Nigeria(Association of Fertility and Reproductive Health, 2016) Omokanye, Lukman O.; Olatinwo, Abdulwaheed O.; Saadu, L.O.; Biliaminu, S.A.; Durowade, K A.; Panti, Abubakar A.Background: According to the World Health Organization, more than 180 million couples globally suffer from infertility, the majority being residents of developing countries. Assisted reproductive technologies (ARTs) offer a chance at parenthood to couples, who until recently would have had no hope of having a “biologically related” child. Objectives: This study aimed to determine pregnancy outcomes following assisted conception. Materials and Methods: This is a prospective study of 104 clients who underwent the procedure of ART between January 1, 2012 and December 31, 2016 at the ART unit of University of Ilorin Teaching Hospital, Ilorin, Nigeria. Results: Of the 510 clients who had infertility consultation at the ART clinic, 104 (20.4%) underwent ART procedures. The patients aged 27–46 years with a mean age of 33 ± 4.0 years. More than half (58.7%) had primary infertility. Their duration of infertility ranged from 1 to 20 years (4.6 ± 2.9 years). Majority (81.7%) had conventional in vitro fertilization while 19 (18.3%) had intracytoplasmic sperm injection. Thirteen (12.5%) cases of cycle cancellation and 11 (11.7%) cases of mild‑to‑moderate ovarian hyperstimulation syndrome were recorded. The clinical pregnancy rate per cycle started was 39.4%. However, 9/41 (22%) resulted in spontaneous miscarriages and 32 (6 sets of twin, 25 singleton, and 1 high‑order multiple births) were successfully delivered, giving a live birth rate per cycle started of 30.8%. Pregnancy outcomes were not significantly affected by age of the women, types of infertility, and duration of infertility (P > 0.05). Conclusion: The outcomes of ART procedures in a resource‑limited country like ours are encouraging. This underscores the need to encourage ART in public tertiary institutions in Nigeria through the support of government and nongovernmental organizations for the benefit of infertile couples who were hitherto hopeless.Item Biochemical Infertility Among Prospective Oocyte Donors at the University of Ilorin Teaching Hospital Assisted Reproductive Unit, Nigeria(College of Health Sciences, University of Ilorin, 2018) Biliaminu, S.A.; Abdul Azeez, I.M.; Akande, A.A.; Okesina, A.B.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.Item Controlled ovarian stimulation protocols in assisted conception: agonist versus antagonist in normal responders(African Journal of Infertility and Assisted Conception, 2017) Omokanye, Lukman O.; Olatinwo, Abdulwaheed O.; Saadu, L.O.; Biliaminu, S.A.; Durowade, K A.; Panti, Abubakar A.; Salaudeen, A.G.Item Determinants of Utilization of Assisted Reproductive Technology services in Ilorin, Nigeria(Regional Institute of Medical Sciences, Imphal, India, 2017) Omokanye, Lukman O.; Olatinwo, Abdulwaheed O.; Durowade, K A.; Raji, H.O.; Raji, S.T.; Biliaminu, S.A.; Salaudeen, A.G.Background: Infertility is the most important reproductive health and social issue confronting married couples in developing countries. Assisted Reproductive Technology (ART) offer a chance at parenthood to couples, who until recently would have had no hope of having a “biologically related” child. Aims and Objectives: This study aimed at determining the factors influencing the utilization of ART services at a public health facility in Ilorin, Nigeria. Materials and Methods: A cross‑sectional descriptive study of consecutively consenting infertile couples seen at the ART unit of the Department of Obstetrics and Gynaecology, University of Ilorin Teaching Hospital, Ilorin, between January 1, 2012, and December 31, 2015. Results: The patients aged 22–52 years with a mean age of 36.1 ± 6.6 years and mean duration of infertility of 7.3 ± 5.8 years. Majority (87.3%) was aware of ART services; only a few (15.6%) had ever used it. Most (63.3%) were of the opinion that ART is financially accessible. Reasons for nonutilization of ART were high cost (44.3%) and nonavailability (29.4%). Measures to enhance the utilization of ART were cost reduction (61.2%) and awareness creation (27.2%). Knowledge on ART practices showed that 56.7% were aware that the procedure could fail and 35.1% knew that it could address male infertility. Female partner age and parity had a significant influence on awareness and utilization of ART services. Conclusion: Awareness of ART services is high; however, utilization is abysmally low. Efforts should be made to make the procedure more affordable and accessible to the masses.Item Determination of glomerular filtration rate using cystatin C in healthy Nigerian newborns(Faculty of Medicine, Alexandria University, Alexandria, Egypt, 2019) Ibrahim, O.R.; Soladoye, A.O; Adeodyin, O.T; Mokuolu, O.A.; Abdulkadir, Mohammed Baba; Biliaminu, S.A.Background: The value of Cystatin C as a biomarker of Glomerular filtration rate (GFR) among African newborns is unknown, due to paucity of studies, restricting the measurement of GFR in this population of newborns to creatinine clearance despite its limitations. This study was therefore conducted to estimate GFR from serum Cystatin C in a population of Nigerian newborns and explored the relationship with anthropometrics. Methods: This was a cross-sectional, analytical study. A total of 60 healthy preterm and 30 healthy term babies were recruited at a tertiary hospital in North-central, Nigeria. Serum Cystatin C was determined using ELISA according to standard methods. Anthropometric measurements were done with standard methods. The GFR was estimated using Zappitelli’s equation. Data were analyzed using SPSS Version 20, and p-value < 0.05 was considered significant. Results: Mean serum Cystatin C was 1.20 ± 0.33 (range 0.80–2.20) mg/L with comparable values in males and females (1.19 ± 0.35 vs 1.15 ± 0.31 mg/L, p = 0.481)). Mean serum Cystatin C among preterm babies were higher than term babies (1.31 ± 0.36 vs 1.01 ± 0.11 mg/L, p = < 0.001). Mean estimated GFR was 65.36 ± 16.9 ml/min/1.732 and was comparable in males and females (64.39 ± 17.95 vs 66.52 ± 15.76 ml/min/1.73 m2 ,p = 0.555). Estimated GFR was lower among preterm than term babies (60.10 ± 17.53 vs 75.89 ± 9.1 ml/min/1.73 m2 , p = < 0.001). Serum cystatin C and estimated GFR moderately correlated with gestational age and anthropometrics (length, occipitofrontal circumference and weight). Conclusions: Serum cystatin C as a biomarker GFR among newborns is low compared with most studies done out of Africa. The serum cystatin C and estimated GFR correlated with the gestational age and anthropometric parameters. The findings relationship between the serum Cystatin C, estimated GFR and anthropometrics among the newborns suggested a need for more studies.Item Evaluation of Ovarian Reserve in Assisted Reproductive Facilities; Biochemical and Other Alternatives: Pros and Cons-A Review Article(Faculty of Medical Laboratory sciences, Usmanu Danfodiyo University, Sokoto, Nigeria, 2017) Biliaminu, S.A.; Abdul Azeez, I.M.; Okesina, A.B.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.; Adunmo, G.O.The precarious rate of infertility has become a global issue. The social and psychological stresses attached to the problem of not having a fruit of womb have necessitated the establishment of assisted reproductive facilities within and outside Nigeria. Most of these Centers are privately owned while very few of them belonging to government. The need for the knowledge or idea of ovarian reserve in female clients of fertility centers is very crucial as it will not only tell the suitability of the client for the procedure but also assist in determining the drugs required for stimulation and the protocol required in a particular client. Various methods are being used in evaluation of ovarian reserve in assisted reproductive facilities some of which are biochemical, ultrasonographic, histopathologic and combined in nature and form. This review article is on evaluation of ovarian reserve in assisted reproductive facilities; biochemical and other alternatives as well as their pros and cons. It was essentially based on literatures and research works written in EnglishItem Female factor infertility: Laparoscopic evaluation at a public health facility in Ilorin, Nigeria.(College of Medicine KLE University, Belgaum, India, 2017) Omokanye, Lukman O.; Ibrahim, S.; Olatinwo, Abdulwaheed O.; Durowade, K.A.; Raji, S.T.; Biliaminu, S.A.; Salaudeen, A.G.BACKGROUND: Infertility is a problem of global proportions, the majority being the residents of developing countries. The contribution of female factor is assuming a tremendous proportion. Laparoscopy remains an indispensable tool in the evaluation of the fertility potential of these female partners. AIMS: This study was aimed at determining the various causes of female factor infertility among female partners of infertile couple in a tertiary health facility. METHODS: A cross-sectional observational study of ninety seven (97) eligible infertile women who underwent diagnostic laparoscopy between 1st January 2012 and 31st December 2015 were enrolled for the study. The data were analyzed using SPSS/PC version 16.0 and p value was preset at <0.05. RESULTS: The patients aged 21-50 years with a mean age of 33.2 ± 6.6 years. Majority (79.4%) were nulliparous. Fifty (51.5%) had primary infertility. Their duration of infertility ranged from 1to 33years (5.7 ± 5.5 years). Most (63.9%) belong to middle social class and their spouse age ranges between 28-60 years (39.0 ± 7.5). More than a quarter had clomiphene resistant Polycystic Ovarian Syndrome, 19 (19.6%) tubal blockage, 13 (13.4%) uterine fibroid and 10 (10.3%) each had endometriosis, peritubal and ovarian adhesions, ovarian cyst and normal findings respectively. There was significant association between patients’ age, intra-operative findings and tubal patency evaluation on laparoscopy (P < 0.05). CONCLUSION: Laparoscopic procedures are less invasive, more convenient and more precise for diagnosis of infertility in women. The common causes responsible for infertility were polycystic ovarian syndrome, tubal occlusion, uterine fibroid, endometriosis, peri-tubovarian adhesions and ovarian cyst.Item Fertility Treatment Protocols on Assisted Reproduction Technology.(Assisted Reproduction Technology Unit (Fertility Research Institute) of University of Ilorin Teaching Hospital., 2018) Omokanye, Lukman O.; Biliaminu, S.A.; Orhue, O.M; Imam, N.T.AItem Gynaecological Laparoscopic Surgeries: A 4- Year audit at the University of Ilorin Teaching Hospital, Nigeria(Society of Gynaecology and Obstetrics of Nigeria, 2017) Omokanye, Lukman O.; Olatinwo, Abdulwaheed O.; Ibrahim, S; Durowade, K.A.; Biliaminu, S.A.; Abdul, I.F.Background: In addition to a shorter hospital stay and better cosmetic results, laparoscopic surgery also offers patients fewer postoperative complications compared to conventional open gynecological surgeries. With expertise and better facilities, it has come to stay as an alternative surgical approach to gynecological diagnosis and treatment. Aims and Objectives: The aim of this study was to assess the indications, intraoperative findings, and types of laparoscopic surgeries performed at the University of Ilorin Teaching Hospital, Ilorin. Materials and Methods: A retrospective observational study of 150 patients who underwent laparoscopic procedures between January 1, 2012 and December 31, 2015, at the Assisted Reproduction Technology (ART) unit of the University of Ilorin Teaching Hospital (UITH), Ilorin, Nigeria. Results: Within the period of our review, there were 1,256 gynecological operations and 150 laparoscopies, thus giving a period prevalence of 11.2%. The patients were aged 20–59 years with a mean age of 32.1 ± 3.9 years. Of the 150 laparoscopies, 30 (20%) had diagnostic laparoscopies while 120 (80%) had therapeutic laparoscopies. Of the 30 patients who had diagnostic laparoscopies, 5 (16.7%) presented with primary infertility and 12 (40%) with secondary infertility. The commonest indication for therapeutic laparoscopy was clomiphene‑resistant polycystic ovary syndrome (PCOS) and was found in 81 (67.5%). One (0.7%) was converted to open surgery due to technical difficulties. There was a case of iatrogenic sigmoid colon injury and no mortality recorded. Conclusion: Laparoscopic surgery offers patients a novel choice of intervention that affords establishing definitive diagnosis, shorter hospital stay, better cosmetics, and reduced morbidities/mortalities compared to open gynecological surgeries.Item Incidence and predictors of acute kidney injury in children with severe malaria(Indonesian Paediatric Society, Indonesia, 2022) Afolayan, FM; Adedoyin, OT; Abdulkadir, Mohammed Baba; Ibrahim, O.R.; Biliaminu, S.A.; Mokuolu, O.A.; Ojuawo, ABackground Acute kidney injury (AKI) is an underrecognized complication of severe malaria and an independent risk factor for mortality among children. Objective To determine the incidence and factors predictive of AKI as defined by the pediatric risk, injury, failure, loss, and end-stage (pRIFLE) criteria in children with severe malaria and to assess in hospital mortality rates in malarial AKI (MAKI). Methods This was a prospective cohort study in 170 children aged 0.5 to 14 years with confirmed Plasmodium falciparum on peripheral blood smears and clinical and/or laboratory features of severe ma laria. Serum creatinine was determined using the Jaffe method and glomerular filtration rate (eGFR) was estimated using the Schwartz equation. The primary outcome was the incidence of AKI as defined by the pRIFLE criteria. Secondary outcomes included in-hospital mortality comparison between AKI and non-AKI groups, as well as factors predictive of AKI. Results The incidence of MAKI was 61.2% and was comparable between males (66.7%) and females (70.6%). Mean eGFR was lower among children with AKI than those without [42.00 (SD 22) vs. 98.7 (SD 3.9) mL/min/1.73m2, respectively; P=0.005]. Children with MAKI were categorized as having risk (47/104; 45.2%), injury (33/104; 31.7%), or failure (24/104; 23.1%). Mortality rates in AKI and non-AKI subjects were comparable (4.8% vs. 4.6%; P=0.888). Predictors of MAKI were hemoglo binuria [adjusted OR (aOR) 3.948; 95%CI 1.138 to 8.030], deep acidotic breathing (aOR 2.991; 95%CI 3.549 to 66.898), and longer hospital stay (aOR 2.042; 95%CI 3.617 to 12.156). Children with MAKI were more likely to have a longer hospital stay by a mean of 2.5 days. Conclusion Acute kidney injury is a common complication in chil dren with severe malaria. Children with MAKI have a mortality rate comparable to those with severe malaria but without AKI. Hemoglobinuria, deep acidotic breathing, and longer hospital stay were predictive of MAKIItem Lipid Profile as a Biomarker of Atherogenicity in Subfertile client with Hyperprolactinemia: A North- Central Nigerian University Teaching Hospital Experience.(Faculty of Medical Laboratory sciences, Usmanu Danfodiyo University, Sokoto, Nigeria, 2017) Abdul Azeez, I.M.; Biliaminu, S.A.; Okesina, A.B.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.; Adunmo, G.O.Hyperprolactinaemia is associated with amenorrhoea and decreased estrogen concentration which may lead to the elevation in total cholesterol and low density lipoprotein cholesterol (LDL-C) and decrease in high density lipoprotein cholesterol (HDL-C). The aim of this present study was to evaluate lipid profile as an artherogenic biomarker in hyperprolactinaemic sub-set of subfertile individuals. This cross-sectional study was carried among clients with hyperprolactinaemia at the Assisted Reproductive Unit of University of Ilorin Teaching Hospital, Ilorin between January and June 2015. Serum fasting total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured in 51 women with hyperprolactinaemia who were non-pregnant and not breastfeeding and 40 age-matched non- pregnant and non-breastfeeding women of child bearing age. Comparisons between serum hormonal profiles as well as lipids profiles as biomarkers of artherogenic index were assessed. Women with hyperprolactinaemia present with significantly lower serum level of FSH, progesterone and oestradiol than those of controls, while there was insignificant elevation in mean LH. There was a significant elevation in the levels of prolactin, testosterone, total cholesterol, triglycerides, HDL-C, LDL-C, mean coronary heart disease risk ratio and Castelli ratio IIin hyperprolactinaemic subjects when compared with controls. In contrast, there was no significant difference when mean values of artherogenic index and Castelli II in hyperprolactinaemic subjects were compared with those of controls. This study revealed an association between hyperprolactinaemia and dyslipidaemia with higher atherogenicity than the controls. We concluded that dyslipidaemia is common in hyperprolactinaemia and as such early lipid profile is advised as well as holistic interpretation of lipid profile as prompt treatment may prevent cardiovascular events in hyperprolactinaemic patientsItem Lipid profile in subfertile clients with premature ovarian failure: University of Ilorin Teaching Hospital(Krishna Institute of Medical Sciences, 2018) Abdul Azeez, I.M.; Biliaminu, S.A.; Okesina, A.B.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.Background: Premature Ovarian Failure (POF) is associated with a higher incidence of cardiovascular events later in life. Concurrent with the ages of menopausal transition, a shift in lipid profile takes place. The increased burden may be mediated by a worsening of cardiovascular risk factors, such as lipids, corresponding with the loss of ovarian function. Aim and Objectives: To investigate serum lipid and hormonal levels in women with premature ovarian failure and compare with those of apparently healthy women of similar age. Material and Methods: The study was a cross-sectional one in which serum fasting Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C) and Low Density Lipoprotein Cholesterol (LDL-C) levels were measured in 50 women with POF and compared with 40 age matched control. Serum hormonal profiles were compared with lipid profiles and biomarkers of atherogenic index were assessed. Results:Women with POF present with statistically significant elevations in the mean values of serum FSH and LH, when compared with those of controls (p<0.001), while there were significant decrease in mean levels of serum prolactin, progesterone, testosterone and oestradiol when subjects were compared with controls (p<0.001). There were statistically significant elevations in serum total cholesterol, triglycerides, HDL-C and LDL-C, in premature ovarian failure subjects when compared with controls (p<0.001). There was statistically significantly difference when mean values of artherogenic index and Castelli ratio II of subjects were compared with those of controls. Conclusion: Loss of ovarian function at a very young age (POF) was characterized with subtle changesin the serum lipid profile (higher TC, TG, HDL-C, and LDL-C levels). It also shows that atherogenic index and Castelli ratio II are better tools for assessment of atherogenicity than CHD risk ratio and Castelli ratio I in patients with POF.Item Non-galactorrheic hyperprolactinaemia in subfertile female patients: A Nigerian tertiary Hospital experience(College of Health Sciences, University of Ilorin, 2017) Biliaminu, S.A.; Abdul Azeez, I.M.; Olatinwo, Abdulwaheed O.; Omokanye, Lukman O.; Ishola, F.; Abdul Azeez, I.F.Item Pattern of Haematological Changes in Patients with Chronic Kidney Disease Attending Nephrology Clinic in a Tertiary Hospital in North Central Nigeria(Amber Publication Ltd, 2020) Sanni, E.O.; Olawumi, H.O.; Durotoye, I.A.; Babatunde, A.S.; Shittu, A.O.; Biliaminu, S.A.; Omokanye, K.O.; Ogunfemi, M.K.; Akinwumi, O.O.; Oyedepo, D.; Dane, S.Introduction: The impact of the disease of the kidney is enormous in developing countries like Nigeria. With the increasing use of erythropoietin stimulating agents in anaemic patients with CKD, there is a need to evaluate the changes in haematological parameters in these patients. This study assessed the haematological changes in patients with known chronic kidney disease. Materials and methods: Our research was a cross-sectional study that assessed and compared the haematologic parameters of 113 patients who had established chronic kidney disease and 113 -healthy controls who were age–and sex-matched. The full blood count (FBC) was determined by SysmexKX21(Sysmex, Japan). The test of significance was set at a P- value of <0.05. Results and Discussion: The mean age of patients with CKD was 55.00 + 15.37 years, whilst that of controls was 52.73±13.59 years. (p-value 0.240) The values of the mean of the Hb and RBC among the patients were 9.69+ 2.25g/dl and 3.62 ± 0.92 x 1012/L respectively and were found to be significantly lower than that seen among controls (13.62 ± 1.45 and 4.94 ± 0.62 respectively) with a P-value<0.001. Significantly higher values of the mean WBC and platelet count were found in the patients when compared with the control participants (p-value<0.001). A significant proportion of our patients had microcytic hypochromic anaemia (32%). Conclusion: Careful evaluation of the cause of anaemia and urgent interventions are needed in the managements of these patients.Item Polycyctic Ovarian Syndrome; Analysis of Management Outcomes among Infertile Women at a Public Health Institution in Nigeria(Wolters-Kluwer-Medknow, 2015) Omokanye, Lukman O.; Ibiwoye-jaiyeola, O.A.; Olatinwo, Abdulwaheed O.; Abdul, I.F.; Durowade, K.A.; Biliaminu, S.A.Background: Infertility remains an issue of concern especially to the female partner who bears the brunt of the stigma attributed to the disease in this environment. Among the identified etiological factors for infertility, polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age that impact on ovulation and conception. Aims and Objectives: The objective of this study was to determine pregnancy outcome following the various modalities of management of PCOS at the University of Ilorin Teaching Hospital (UITH). Materials and Methods: This is a nonrandomized (nonblinded) clinical trial of five therapeutic options for infertile women with PCOS from the Assisted Reproductive Technology (ART) Clinic and Gynaecology Clinic of UITH between January 1, 2011 and December 31, 2013. Results: Of 624 infertile women who presented at ART and general gynecology clinic of UITH, 76 met the Rotterdam criteria for PCOS, giving a prevalence rate of 12.2%. The patients aged 20–44 years with a mean age of 31.5 years. Most 49 (64.5%) of the patients were nulliparous, and more than half (56.6%) belong to the middle social class. Thirty‑four (44.8%) were obese while 22 (28.9%) were overweight. Of the various management options, 48.7% had laparoscopic ovarian drilling; other treatment options offered were the use of clomiphene citrate (CC) alone, CC with metformin, weight reduction, and gonadotropin. Patients were followed‑up within 6–12 months (mean 5.5 ± 1.2 months) following the initial treatment for evidence of laboratory/clinical pregnancy. An overall pregnancy rate of 46.0% was recorded. However, a total of 13 (17.1%) were lost to follow‑up. The highest pregnancy rate (75%) was reported in women managed with CC alone (P = 0.229). Conclusion: PCOS occurs commonly in reproductive age and management outcomes are promising in Nigeria. CC, metformin, and laparoscopic ovarian drilling are of great benefit. Further studies on PCOS in low resource countries are needed.