Lipid Profile as a Biomarker of Atherogenicity in Subfertile client with Hyperprolactinemia: A North- Central Nigerian University Teaching Hospital Experience.
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Date
2017
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Faculty of Medical Laboratory sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
Abstract
Hyperprolactinaemia is associated with amenorrhoea and decreased estrogen concentration which may lead to the elevation in total cholesterol and low density lipoprotein cholesterol (LDL-C) and decrease in high density lipoprotein cholesterol (HDL-C). The aim of this present study was to evaluate lipid profile as an artherogenic biomarker in hyperprolactinaemic sub-set of subfertile individuals. This cross-sectional study was carried among clients with hyperprolactinaemia at the Assisted Reproductive Unit of University of Ilorin Teaching Hospital, Ilorin between January and June 2015. Serum fasting total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured in 51 women with hyperprolactinaemia who were non-pregnant and not breastfeeding and 40 age-matched non- pregnant and non-breastfeeding women of child bearing age. Comparisons between serum hormonal profiles as well as lipids profiles as biomarkers of artherogenic index were assessed. Women with hyperprolactinaemia present with significantly lower serum level of FSH, progesterone and oestradiol than those of controls, while there was insignificant elevation in mean LH. There was a significant elevation in the levels of prolactin, testosterone, total cholesterol, triglycerides, HDL-C, LDL-C, mean coronary heart disease risk ratio and Castelli ratio IIin hyperprolactinaemic subjects when compared with controls. In contrast, there was no significant difference when mean values of artherogenic index and Castelli II in hyperprolactinaemic subjects were compared with those of controls. This study revealed an association between hyperprolactinaemia and dyslipidaemia with higher atherogenicity than the controls. We concluded that dyslipidaemia is common in hyperprolactinaemia and as such early lipid profile is advised as well as holistic interpretation of lipid profile as prompt treatment may prevent cardiovascular events in hyperprolactinaemic patients
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Keywords
Biochemical, artherogenicity, hyperprolactinaemia, subfertile client, North-central, Nigeria