Determination of glomerular filtration rate using cystatin C in healthy Nigerian newborns
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Faculty of Medicine, Alexandria University, Alexandria, Egypt
Abstract
Background: The value of Cystatin C as a biomarker of Glomerular filtration rate (GFR) among
African newborns is unknown, due to paucity of studies, restricting the measurement of GFR in
this population of newborns to creatinine clearance despite its limitations. This study was
therefore conducted to estimate GFR from serum Cystatin C in a population of Nigerian
newborns and explored the relationship with anthropometrics.
Methods: This was a cross-sectional, analytical study. A total of 60 healthy preterm and 30
healthy term babies were recruited at a tertiary hospital in North-central, Nigeria. Serum
Cystatin C was determined using ELISA according to standard methods. Anthropometric
measurements were done with standard methods. The GFR was estimated using Zappitelli’s
equation. Data were analyzed using SPSS Version 20, and p-value < 0.05 was considered
significant.
Results: Mean serum Cystatin C was 1.20 ± 0.33 (range 0.80–2.20) mg/L with comparable values
in males and females (1.19 ± 0.35 vs 1.15 ± 0.31 mg/L, p = 0.481)). Mean serum Cystatin C among
preterm babies were higher than term babies (1.31 ± 0.36 vs 1.01 ± 0.11 mg/L, p = < 0.001). Mean
estimated GFR was 65.36 ± 16.9 ml/min/1.732 and was comparable in males and females
(64.39 ± 17.95 vs 66.52 ± 15.76 ml/min/1.73 m2
,p = 0.555). Estimated GFR was lower among
preterm than term babies (60.10 ± 17.53 vs 75.89 ± 9.1 ml/min/1.73 m2
, p = < 0.001). Serum
cystatin C and estimated GFR moderately correlated with gestational age and anthropometrics
(length, occipitofrontal circumference and weight).
Conclusions: Serum cystatin C as a biomarker GFR among newborns is low compared with
most studies done out of Africa. The serum cystatin C and estimated GFR correlated with the
gestational age and anthropometric parameters. The findings relationship between the serum
Cystatin C, estimated GFR and anthropometrics among the newborns suggested a need for
more studies.
Description
Keywords
Glomerular filtration rate; cystatin C; Nigerian; newborns
Citation
Ibrahim, O. R., Soladoye, A. O., Adedoyin, T. O., Mokuolu, O. A., Abdulkadir, M. B., & Biliaminu, S. A. (2019). Determination of glomerular filtration rate using cystatin C in healthy Nigerian newborns. Alexandria Journal of Medicine, 55(1), 89-94