Browsing by Author "Biliaminu, S. A."

Now showing 1 - 7 of 7
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    Effect of garcina kola seed on plasma C-reactive protein in human subjects
    (The Nigerian Journal of Pure & Applied Sciences,, 2013) Owoyele, B. V.,; Oyewole, A.L.; Amuda, O.,; Abioye, A.; Biliaminu, S. A.
    Garcinia kola seed ( Garcinia afzelii; also called bitter kola seed) i s a common .Africa snack fruit from a species of flowering plant in the Guttiferae family. Over the years, Africa traditional medicine and ethino pharmacology have attached invaluable roles to Garcinia kola seed (GKS) as a potent anti­hepatotoxic, anti-diabetic. antioxidant and antilisterial. To consolidate these roles. we focus our study on the effect of GKS on C-reactive protein (CRP) in human subjects. Sixty students voluntccrs (n=60 30 female & 30 male) from Faculty of Basic Medical Sciences. U nivcrsl ty of I lorin. N igeria. were used for this study. The screened voluntccrs were subjected to an hour rest for acclitnatization. This was follow by collection of about 2.5 ml of blood through venc puncture. The subjects were then asked to ingest 100 mg/k g of GKS and after 6 hours, another 2.5 ml of blood sample was collected from each subject. The level of C'RP was assay in the two sets of blood samples. The result shows 66.31%, significant decrease in the mean level of basal CRP of the female (p< 0.05). Contrast to this, inmale, there is 72.2 7% signi ficant increase from the mean level of basal CRP (p < 0.05). In conclusion. this study shows GKS as a potent anti-in flammatory fruit for female suhjects but not for male subjects. GKS anti-inflammatory effects are thus gender based. With these observations. it can be said to be more beneficial to female but not to male subjects . Lastly. the clinical practse or using CRP level in the blood to predict the pathogenesis of a disease, track of a disease progress or measure of effcct iveness of a treatment will be mislcading in habitual GKS consuming pati ents.
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    Effect of gliclazide on uric acid and C-reactive protein in alloxan-induced diabetic rats
    (Published by University of Ilorin, Ilorin, Nigeria, 2012) Ojulari, L. S.; Biliaminu, S. A.; Dangana, E. O.; Abdulazeez, F. I.; Ayinde, T. O.; Adegoke, O. A.
    global health. It contributes to oxidative stress and also induces inflammation and hence severe complications. Several drugs have been introduced so far to salvage this metabolic disease alongside its complications. Objectives: This study was designed to investigate the effects of gliclazide on serum uric acid and C-reactive protein (a biomarker of inflammation) in alloxan-induced diabetic rats. Materials and Methods: Sixteen wistar rats were divided into 4 experimental groups with four rats each; Group A-control (Drug vehicle), Group B-diabetic, Group C- diabetic/gliclazide (10mg/kg twice daily for 28days) and Group D-normal/gliclazide (10mg/kg twice daily for 28 days). At the end of the experimental period (four weeks), animals in all groups were fasted for 12 hours and blood samples were taken by cardiac puncture for determination of serum uric acid and C-reactive protein (CRP) levels. Results: The study shows no significant statistical change in the serum uric acid levels (p>0.05) when the Experimental groups were compared with the controls. On the other hand, there was significant decrease (p<0.05) in CRP levels when values in the controls were compared with diabetic treated and normal treated groups. Conclusion: This finding may suggests that gliclazide possesses cardioprotective property since CRP has been implicated in atherosclerotic changes which is a common complication of diabetes mellitus. This may be through its anti-inflammatory effect by reducing the plasma concentration of IL-6, which is produced predominantly by macrophages and so prevents diabetic complications.
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    Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease model
    (Korean Association of Anatomists, 2024) Sulaimon, F. A.; Ibiyeye, R. Y.; Imam, A.; Oyewole, A. L.; Imam, A. L.; Shehu, M.; Biliaminu, S. A.; Kadir, R. E.; Omotoso, G. O.; Ajao, M. S.
    : Parkinson’s disease (PD) affects about 8.5 million individuals worldwide. Oxidative and inflammatory cascades are implicated in the neurological sequels, that are mostly unresolved in PD treatments. However, proper nutrition offers one of the most effective and least costly ways to decrease the burden of many diseases and their associated risk factors. Moreover, prevention may be the best response to the progressive nature of PD, thus, the therapeutic novelty of honey and levodopa may be prospective. This study aimed to investigate the neuroprotective role of honey and levodopa against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced oxidative stress. Fifty-four adult male Swiss mice were divided into control and PD model groups of 27 mice. Each third of the control mice either received phosphate buffered saline, honey, or levodopa for 21 days. However, each third of the PD models was either pretreated with honey and levodopa or not pretreated. Behavioral studies and euthanasia were conducted 2 and 8 days after MPTP administration respectively. The result showed that there were significantly (P<0.05) higher motor activities in the PD models pretreated with the honey as well as levodopa. furthermore, the pretreatments protected the midbrain against the chromatolysis and astrogliosis induced by MPTP. The expression of antioxidant markers (glutathione [GSH] and nuclear factor erythroid 2-related factor 2 [Nrf2]) was also significantly upregulated in the pretreated PD models. It is thus concluded that honey and levodopa comparably protected the substantia nigra pars compacta neurons against oxidative stress by modulating the Nrf2 signaling molecule thereby increasing GSH level to prevent MPTP-induced oxidative stress.
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    Pattern of haemopoietic progenitor cells differentiation and differentiation enhancing effect of Telfairia occidentalis extract in irradiated guinea-pig
    (College of Health Sciences, University of Ilorin, 2021-10) Olatubosun, L. O.; Khalil, E. A. G.; Atunwa, A.; Olalere, F. D.; Lawal, S. A.; Biliaminu, S. A.; Ogunwale, K. A. T; Omokanye, K.; Babatunde, A. S.; AbdulRaheem, O. J.; Afolabi, O. O.; Bashir, A.; Lawal, I. K.
    Ionizing radiation is essentially considered a viable treatment modality for human malignancies. Acute and chronic toxicities with severe morbidity and mortality are well documented. Experimental and clinical approaches to correcting radiation haemopoietic syndrome deficiencies have focused on cytokine activity with same documented toxici ties . Limited data is available on differentiation enhancing effects of plant extracts on haemopoietic progenitor cells following radiation injury. This study aimed to determine the potential haemopoietic progenitor cells differentiation effects of Telfairia occidentalis in irradiated guinea pigs. Bone marrow cells from irradiated guinea pigs were harvested and treated with varying concentrations of 0.313-100% of the extracts of the Telfairia occidentalis and the degree of differentiation of the cultured guinea-pig bone marrow haemopoietic stem cells determined. The concentration of the extract ranges from 0.313-100%. This showed Mean± SD of 3.54±0.30, 0.18±0.01 and 0.88±0.05 for the extract treated, non-extract treated (-ve control) and GM-CSF (+ve control) treated culture plates respectively [p=0.000].
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    Study on comparison of serum levels of calcium magnesium and uric in mild preeclamptics severe preeclamptics, normal pregnant women in ilorin, Nigeria
    (Nigeria journal of experimental and clinical biosciences, 2015) Omotayo, Omokanye Lukman; Abdul, Kareem; Durowade, A. W. O.; Biliaminu, S. A.
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    The Effect of Metformin on Serum Levels of FSH, LH, Oestrogen and Progesterone in Diabetic Rats
    (College of Health Sciences, University of Ilorin, Ilorin, Nigeria, 2013) Ojulari, L. S.; Biliaminu, S. A.; Ahmed, T. T.; Abdulazeez, F. I.; Oyekunle, O. F.; Niyi-Odumosu, F. A.; Adegoke, O. A.
    Diabetes mellitus represents one of the greatest global health threats. It contributes to sub-fertility in females and impairs the normal menstrual cycle and ovulation. This study was designed to investigate the effect of oral administration of metformin on FSH, LH, oestrogen, and progesterone in diabetic rats. Twenty female rats were divided into four experimental groups of five rats each. Group A (control) received distilled water ad libitum. Group B were diabetic untreated; Group C received metformin only; Group D were diabetic and received metformin. At the end of the four-week treatment period, blood samples were collected for hormone assays. The results showed significant (P<0.05) reductions in FSH and LH levels in all experimental groups compared to control. Progesterone levels significantly increased in Groups B and D compared to control, while oestrogen levels were reduced in all experimental groups but insignificantly (P>0.05). The study suggests that metformin’s ovulation-inducing effect is likely due to its direct action on the ovary, and not solely due to improved insulin sensitivity.
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    Thymoquinone ameliorate oxidative stress, GABAergic neuronal depletion and memory impairment through Nrf2/ARE signaling pathway in the dentate gyrus following cypermethrin administration
    (BMC Neuroscience, 2024) Imam, A. L.; Okesina, A. A.; Sulaimon, F. A.; Imam, A.; Ibiyeye, R. Y.; Oyewole, L. A.; Biliaminu, S. A.; Shehu, M.; Alli, A. O.; Omoola, O. O.; Ajao, M.S.
    Background Exposure to chemical toxins, including insecticides, harms bodily organs like the brain. This study examined the neuroprotective of thymoquinone on the cypermethrin’s harmful effects on the histoarchitecture of the dentate gyrus and motor deficit in the dentate gyrus. Methods Forty adult male rats (180–200 g) were randomly divided into 5 groups (n=8 per group). Groups I, II, III, IV, and V received oral administration of 0.5 ml of phosphate-buffered saline, cypermethrin (20 mg/kg), thymoquinone (10 mg/kg), cypermethrin (20 mg/kg)+thymoquinone (5 mg/kg), and cypermethrin (20 mg/kg)+thymoquinone (10 mg/kg) for 14 days respectively. The novel object recognition test that assesses intermediate-term memory was done on days 14 and 21 of the experiment. At the end of these treatments, the animals were euthanized and taken for cytoarchitectural (hematoxylin and eosin; Cresyl violet) and immunohistochemical studies (Nuclear factor erythroid 2-related factor 2 (Nrf2), Parvalbumin, and B-cell lymphoma 2 (Bcl2). Result The study shows that thymoquinone at 5 and 10 mg/kg improved Novelty preference and discrimination index. Thymoquinone enhanced Nissl body integrity, increased GABBAergic interneuron expression, nuclear factor erythroid 2-derived factor 2, and enhanced Bcl-2 expression in the dentate gyrus. It also improved the concentration of nuclear factor erythroid 2-derived factor 2, increased the activities of superoxide dismutase and glutathione, and decreased the concentration of malondialdehyde level against cypermethrin-induced neurotoxicity. Conclusion thymoquinone could be a therapeutic agent against cypermethrin poisoning.